الأدوية والمكملات الغذائية

Proper Use

Drug information provided by: Merative, Micromedex®

Vial: A nurse or other trained health professional will give you this medicine in a medical facility. It is given through an IV that is placed in one of your veins to treat active ankylosing spondylitis, non-radiographic axial spondyloarthritis, or psoriatic arthritis. It must be given slowly, so the IV will have to remain in place for at least 30 minutes.

Prefilled syringe or pen: You may also be taught how to give your medicine at home. It is usually given as a shot under the skin of your stomach, thigh, or upper arm to treat ankylosing spondylitis, enthesitis-related arthritis, hidradenitis suppurativa, non-radiographic axial spondyloarthritis, plaque psoriasis, or psoriatic arthritis.

This medicine comes with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Secukinumab comes in 6 forms: a Sensoready® pen, an UnoReady® pen, a 300 mg/2 mL prefilled syringe, a 150 mg/mL prefilled syringe, a 75 mg/0.5 mL prefilled syringe for children (these 5 forms may be used at home), and vial (which is to be used only in the hospital or doctor's office). Your doctor will tell you which dosage form you should use.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself or your child a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject into skin areas that are red, bruised, tender, hard, or affected by psoriasis.

Allow the medicine to warm to room temperature for 15 to 30 minutes (for Sensoready® pen, 150 mg/mL prefilled syringe, and 75 mg/0.5 mL prefilled syringe) and 30 to 45 minutes (for UnoReady® pen and 300 mg/2 mL prefilled syringe) before using it.

You might not use all of the medicine in each pen or prefilled syringe. Use each pen or prefilled syringe only one time. Do not save an open pen or syringe. If the medicine in the pen or syringe has changed color, or if you see particles in it, do not use it. Do not shake the medicine.

The removable cap of the Sensoready® pen or prefilled syringe contains dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you have a latex allergy before you start receiving this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form (prefilled syringe or pen):
  • For ankylosing spondylitis:
    • Adults—150 milligrams (mg) every 4 weeks. Some patients may first receive "loading" doses of 150 mg at weeks 0, 1, 2, 3, and 4 and then begin the every-4-weeks regimen. Patients with continuing active ankylosing spondylitis may receive a dose of 300 mg every 4 weeks given as one 300 mg injection or two 150 mg injections.
    • Children—Use and dose must be determined by your doctor.
  • For enthesitis-related arthritis:
    • Adults and children 4 years of age and older weighing 50 kilograms (kg) or more—150 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 150 mg every 4 weeks.
    • Children 4 years of age and older weighing 15 kg to less than 50 kg—75 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 75 mg every 4 weeks.
    • Children younger than 4 years of age or weighing less than 15 kg—Use and dose must be determined by your doctor.
  • For hidradenitis suppurativa:
    • Adults—300 milligrams (mg) injected under the skin at weeks 0, 1, 2, 3, and 4. Followed by 300 mg every 4 weeks. Patients not responding to this regimen may receive a dose of 300 mg every 2 weeks given as one 300 mg injection or two 150 mg injections.
    • Children—Use and dose must be determined by your doctor.
  • For non-radiographic axial spondyloarthritis:
    • Adults—150 milligrams (mg) every 4 weeks. Some patients may first receive "loading" doses of 150 mg at weeks 0, 1, 2, 3, and 4 and then begin the every-4-weeks regimen.
    • Children—Use and dose must be determined by your doctor.
  • For plaque psoriasis:
    • Adults—At first, 300 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 300 mg every 4 weeks given as one 300 mg injection or two 150 mg injections. Some patients may receive a dose of 150 mg.
    • Children 6 years of age and older weighing 50 kilograms (kg) or more—150 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 150 mg every 4 weeks.
    • Children 6 years of age and older weighing less than 50 kg—75 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 75 mg every 4 weeks.
    • Children younger than 6 years of age—Use and dose must be determined by your doctor.
  • For psoriatic arthritis:
    • Adults—150 milligrams (mg) injected under your skin every 4 weeks. Some patients may first receive "loading" doses of 150 mg at weeks 0, 1, 2, 3, and 4, and then begin the every-4-weeks regimen. Patients with continuing active psoriatic arthritis may receive a dose of 300 mg every 4 weeks given as one 300 mg injection or two 150 mg injections. Patients who also have moderate to severe plaque psoriasis should receive the dose for plaque psoriasis.
    • Children 2 years of age and older weighing 50 kilograms (kg) or more—150 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 150 mg every 4 weeks.
    • Children 2 years of age and older weighing 15 kg to less than 50 kg—75 milligrams (mg) injected under your skin at weeks 0, 1, 2, 3, and 4. Followed by 75 mg every 4 weeks.
    • Children younger than 2 years of age or weighing less than 15 kg—Use and dose must be determined by your doctor.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Keep the medicine in the original carton until you are ready to use it. This medicine may be stored for up to 4 days at room temperature if removed from the refrigerator. Throw the medicine away if it has been stored at room temperature for more than 4 days. Write the date the medicine is removed from and returned to the refrigerator. This medicine may be returned to the refrigerator once and then stored in the refrigerator until used or expired.

Do not reuse syringes and needles. Put used syringes and needles in a puncture-resistant disposable container, or dispose of them as directed by your doctor.