الأدوية والمكملات الغذائية

Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ozanimod in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ozanimod in the elderly. However, elderly patients are more likely to have liver or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Amphetamine
• Benzphetamine
• Bupropion
• Carbamazepine
• Citalopram
• Codeine
• Desvenlafaxine
• Dexmethylphenidate
• Dextroamphetamine
• Dextromethorphan
• Duloxetine
• Escitalopram
• Fluoxetine
• Fluvoxamine
• Furazolidone
• Gepirone
• Hydroxyamphetamine
• Iproniazid
• Isocarboxazid
• Levomilnacipran
• Linezolid
• Lisdexamfetamine
• Methamphetamine
• Methylene Blue
• Methylphenidate
• Milnacipran
• Moclobemide
• Nialamide
• Paroxetine
• Phenelzine
• Procarbazine
• Rasagiline
• Safinamide
• Selegiline
• Serdexmethylphenidate
• Sertraline
• Tramadol
• Tranylcypromine
• Venlafaxine
• Vilazodone
• Viloxazine
• Vortioxetine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abiraterone Acetate
• Adenovirus Vaccine, Live
• Albuterol
• Alemtuzumab
• Alfentanil
• Alfuzosin
• Amineptine
• Amiodarone
• Amisulpride
• Amitriptyline
• Amitriptylinoxide
• Amoxapine
• Anagrelide
• Anileridine
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asciminib
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bacillus of Calmette and Guerin Vaccine, Live
• Bedaquiline
• Benzhydrocodone
• Bepridil
• Buprenorphine
• Buserelin
• Butalbital
• Butorphanol
• Capmatinib
• Ceritinib
• Chloroquine
• Chlorpromazine
• Cholera Vaccine, Live
• Ciprofloxacin
• Cisapride
• Clarithromycin
• Clofazimine
• Clomipramine
• Clozapine
• Crizotinib
• Cyclobenzaprine
• Cyclosporine
• Dabrafenib
• Darolutamide
• Dasatinib
• Degarelix
• Delamanid
• Dengue Tetravalent Vaccine, Live
• Desipramine
• Deslorelin
• Deutetrabenazine
• Diacetylmorphine
• Dibenzepin
• Difenoxin
• Dihydrocodeine
• Diphenoxylate
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Dronedarone
• Droperidol
• Ebastine
• Ebola Zaire Vaccine, Live
• Efavirenz
• Eltrombopag
• Enasidenib
• Encorafenib
• Entrectinib
• Eribulin
• Erythromycin
• Ethylmorphine
• Famotidine
• Felbamate
• Fentanyl
• Fingolimod
• Flecainide
• Fluconazole
• Formoterol
• Foscarnet
• Fosphenytoin
• Galantamine
• Gatifloxacin
• Gemfibrozil
• Gemifloxacin
• Glasdegib
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydrocodone
• Hydromorphone
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imipramine
• Influenza Virus Vaccine, Live
• Inotuzumab Ozogamicin
• Itraconazole
• Ivabradine
• Ivosidenib
• Ketobemidone
• Ketoconazole
• Lapatinib
• Leniolisib
• Lenvatinib
• Leuprolide
• Levofloxacin
• Levorphanol
• Lofepramine
• Lofexidine
• Lumefantrine
• Macimorelin
• Measles Virus Vaccine, Live
• Mefloquine
• Melitracen
• Meperidine
• Mesoridazine
• Methadone
• Methotrimeprazine
• Metronidazole
• Midostaurin
• Mifepristone
• Mizolastine
• Momelotinib
• Moricizine
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Mumps Virus Vaccine, Live
• Nafarelin
• Nalbuphine
• Nefazodone
• Nelfinavir
• Nicomorphine
• Nilotinib
• Norepinephrine
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Omaveloxolone
• Ondansetron
• Opipramol
• Opium
• Opium Alkaloids
• Osimertinib
• Oxycodone
• Oxymorphone
• Paliperidone
• Panobinostat
• Papaveretum
• Papaverine
• Paregoric
• Pasireotide
• Pazopanib
• Pentamidine
• Perphenazine
• Phenobarbital
• Pimavanserin
• Pimozide
• Pipamperone
• Piperaquine
• Piritramide
• Pitolisant
• Poliovirus Vaccine, Live
• Posaconazole
• Primidone
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Remifentanil
• Ribociclib
• Rifampin
• Risperidone
• Ritonavir
• Rotavirus Vaccine, Live
• Rubella Virus Vaccine, Live
• Saquinavir
• Sertindole
• Sevoflurane
• Sibutramine
• Siponimod
• Smallpox Monkeypox Vaccine, Live Non-Replicating
• Smallpox Vaccine
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Sparfloxacin
• Sufentanil
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Tafamidis
• Tamoxifen
• Tapentadol
• Telaprevir
• Telavancin
• Telithromycin
• Terfenadine
• Tetrabenazine
• Thioridazine
• Tianeptine
• Tilidine
• Tolterodine
• Toremifene
• Trazodone
• Triclabendazole
• Trimipramine
• Triptorelin
• Typhoid Vaccine, Live
• Valbenazine
• Vandetanib
• Vardenafil
• Varicella Virus Vaccine, Live
• Velpatasvir
• Vemurafenib
• Vilanterol
• Vinflunine
• Voriconazole
• Vorinostat
• Voxilaprevir
• Yellow Fever Vaccine
• Ziprasidone
• Zoster Vaccine, Live
• Zotepine
• Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose
• Chlorpropamide
• Glimepiride
• Glipizide
• Glyburide
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glargine, Recombinant
• Insulin Glulisine
• Insulin Lispro, Recombinant
• Metformin
• Nateglinide
• Repaglinide
• Tolazamide
• Tolbutamide

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Tyramine Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (chest pain), unstable (within the last 6 months) or
• Heart attack (within the last 6 months) or
• Heart failure (within the last 6 months) or
• Heart rhythm problems (eg, Mobitz type II second-degree, third-degree heart block, sick sinus syndrome), without a pacemaker or
• Sleep apnea, severe and untreated or
• Stroke, including transient ischemic attack (within the last 6 months)—Should not be used in patients with these conditions.

• Breathing problems or
• Heart rhythm problems (eg, slow heartbeat, QT prolongation) or
• Hypertension (high blood pressure) or
• Liver disease or
• Lymphopenia (low white blood cells) or
• Macular edema (swelling at the back of your eye)—Use with caution. May make these conditions worse.

• Diabetes, history of or
• Uveitis (eye problem), history of—May increase risk of macular edema.

• Infection (eg, chicken pox, herpes zoster)—May decrease your body's ability to fight infection.