Fosnetupitant/Palonosetron (Intravenous Route) Description and Brand Names

Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

Akynzeo

Descriptions

Fosnetupitant and palonosetron combination injection is used together with dexamethasone to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy). Palonosetron and fosnetupitant work by blocking the signals to the brain that cause nausea and vomiting.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

Solution
Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of fosnetupitant and palonosetron combination injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fosnetupitant and palonosetron combination injection in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution in patients receiving fosnetupitant and palonosetron combination.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Apomorphine
Eliglustat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Acalabrutinib
Alfentanil
Alfuzosin
Almotriptan
Alprazolam
Amineptine
Amiodarone
Amitriptyline
Amitriptylinoxide
Amlodipine
Amoxapine
Amphetamine
Aprepitant
Aripiprazole
Atorvastatin
Avanafil
Avapritinib
Axitinib
Benzhydrocodone
Benzphetamine
Bosutinib
Brigatinib
Bromocriptine
Brompheniramine
Budesonide
Buprenorphine
Buspirone
Butorphanol
Cabozantinib
Capivasertib
Carbamazepine
Chlorpheniramine
Cilostazol
Cisapride
Citalopram
Clarithromycin
Clomipramine
Clozapine
Cobicistat
Cobimetinib
Cocaine
Codeine
Colchicine
Conivaptan
Copanlisib
Crizotinib
Cyclobenzaprine
Cyclosporine
Dabrafenib
Daclatasvir
Daridorexant
Darifenacin
Darunavir
Dasatinib
Desipramine
Desvenlafaxine
Dextroamphetamine
Dextromethorphan
Diazepam
Dibenzepin
Dihydrocodeine
Dihydroergotamine
Diltiazem
Docetaxel
Dofetilide
Domperidone
Doxepin
Dronedarone
Duloxetine
Efavirenz
Elacestrant
Elbasvir
Eletriptan
Elexacaftor
Encorafenib
Entrectinib
Enzalutamide
Eplerenone
Ergotamine
Erythromycin
Escitalopram
Estradiol
Eszopiclone
Everolimus
Fedratinib
Felodipine
Fenfluramine
Fentanyl
Fexinidazole
Finerenone
Flibanserin
Fluoxetine
Fluticasone
Fluvoxamine
Fosaprepitant
Fosphenytoin
Frovatriptan
Furazolidone
Gepirone
Granisetron
Grazoprevir
Guanfacine
Haloperidol
Hydrocodone
Hydrocortisone
Hydromorphone
Hydroxyamphetamine
Hydroxytryptophan
Ibrutinib
Imatinib
Imipramine
Indinavir
Infigratinib
Iproniazid
Irinotecan
Irinotecan Liposome
Isocarboxazid
Itraconazole
Ivabradine
Ivacaftor
Ivosidenib
Lapatinib
Larotrectinib
Lasmiditan
Lemborexant
Lercanidipine
Levomilnacipran
Levorphanol
Linezolid
Lisdexamfetamine
Lithium
Lofepramine
Lomitapide
Lorcaserin
Lovastatin
Lumacaftor
Lumateperone
Lurasidone
Lurbinectedin
Maraviroc
Mavacamten
Melitracen
Meperidine
Metaxalone
Methadone
Methamphetamine
Methylene Blue
Midazolam
Milnacipran
Mirtazapine
Mitapivat
Mitotane
Mobocertinib
Moclobemide
Morphine
Morphine Sulfate Liposome
Nalbuphine
Naloxegol
Naratriptan
Nateglinide
Nefazodone
Nelfinavir
Neratinib
Nialamide
Nifedipine
Nilotinib
Nirogacestat
Nisoldipine
Nortriptyline
Oliceridine
Omaveloxolone
Omeprazole
Ondansetron
Opipramol
Oxycodone
Oxymorphone
Paclitaxel
Pacritinib
Palovarotene
Paritaprevir
Paroxetine
Pemigatinib
Pentazocine
Pexidartinib
Phenelzine
Phenobarbital
Phenytoin
Pimavanserin
Pimozide
Piperaquine
Pralsetinib
Primidone
Procarbazine
Progesterone
Protriptyline
Quetiapine
Quinidine
Ranolazine
Rasagiline
Reboxetine
Remifentanil
Repaglinide
Repotrectinib
Rifabutin
Rifampin
Rimegepant
Rizatriptan
Roflumilast
Rolapitant
Salmeterol
Saquinavir
Saxagliptin
Selegiline
Selpercatinib
Selumetinib
Sertraline
Sibutramine
Sildenafil
Simeprevir
Simvastatin
Sirolimus
Sirolimus Protein-Bound
Sonidegib
Sparsentan
St John's Wort
Sufentanil
Sumatriptan
Sunitinib
Suvorexant
Tacrolimus
Tamoxifen
Tapentadol
Tazemetostat
Telithromycin
Temsirolimus
Tezacaftor
Thiotepa
Tianeptine
Ticagrelor
Tipranavir
Tolvaptan
Trabectedin
Tramadol
Tranylcypromine
Trazodone
Triazolam
Trimipramine
Tryptophan
Ubrogepant
Vardenafil
Venetoclax
Venlafaxine
Verapamil
Vilazodone
Vinblastine
Vincristine
Vinorelbine
Voclosporin
Vorapaxar
Vortioxetine
Warfarin
Zaleplon
Zanubrutinib
Ziprasidone
Zolmitriptan
Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Dexamethasone

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will have to remain in place for at least 30 minutes, about 30 minutes before starting your cancer treatment.

This medicine should come with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that it is working properly and to check for unwanted effects.

This medicine may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

Agitation
confusion
cough or hoarseness
dizziness
fast heartbeat
fever
hearing or seeing things that are not there
hives, itching, skin rash
irritation
joint pain, stiffness or swelling
muscle twitching
overactive reflexes
poor coordination
redness of the skin
shivering
sweating
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
trembling or shaking
trouble breathing or swallowing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Headache
unusual tiredness or weakness

Less common

Constipation
heartburn
indigestion
stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: May 01, 2024

Original article: https://www.mayoclinic.org/ar/drugs-supplements/fosnetupitant-palonosetron-intravenous-route/description/drg-20425898

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