الأدوية والمكملات الغذائية

Proper Use

Drug information provided by: Merative, Micromedex®

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Fentanyl nasal sprays are for use in opioid-tolerant patients only. If you are not sure whether or not you are opioid-tolerant, check with your doctor before using this medicine.

It is very important that you understand the rules of the TIRF REMS program to prevent addiction, abuse, and misuse of fentanyl. This medicine should also come with a Medication Guide and patient instructions. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.

This medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off with water right away.

Fentanyl nasal spray works differently than other fentanyl products, even at the same dose. Do not substitute or convert it to other products containing fentanyl.

To use the nasal spray:

• Keep the spray in the child-resistant container until ready to use.
• If you are using the nasal spray for the first time, you must prime the spray. Press on the grips and then release. You will hear a "click" and you will see 1 wide red bar in the counting window. Keep pressing and releasing the grip 3 more times. Each time, the red bar will become smaller until you see a green bar in the counting window. Prime the spray if it has not been used for more than 5 days. Re-prime by spraying 1 time into the pouch.
• Gently blow your nose before using the spray. Sit up with your head upright and insert the tip of the nose piece into your nostril, and point the tip toward the bridge of your nose.
• Close the opposite nostril with a finger. Firmly press down on the finger grips until you hear a "click".
• Breathe in gently through your nose and out through your mouth one time after spraying. Do not sniff. Avoid blowing your nose for at least 30 minutes. Sit down for at least 1 minute.
• Throw this medicine away after 8 sprays.

If another dose is needed, wait at least 2 hours before treating another episode of breakthrough pain.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For nasal dosage form (spray):
  • For cancer pain:
    • Adults—At first, 100 micrograms (mcg) or 1 spray in one nostril during an episode of breakthrough cancer pain. Your doctor may increase your dose as needed and tolerated. The dose is usually not more than 4 sprays per episode of pain.
    • Children—Use and dose must be determined by your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Ask your pharmacist about the best way to dispose of medicine that you do not use. Throw away the spray bottle and start using a new one if you have used 8 sprays or if it has been 60 days or more since it has been used. Dispose any used, partially used, or unneeded spray bottles by emptying and spraying the remaining solution into the pouch. The sealed pouch and the empty bottle should be placed in a child-resistant container before discarding it in the trash can. Wash your hands with soap and water right away after handling the pouch.