الأدوية والمكملات الغذائية

Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of digoxin injection to treat atrial fibrillation in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of digoxin injection in children with heart failure. However, infants are more likely to be very sensitive to the effects of digoxin injection which may require an individual dose for infants receiving digoxin injection.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of digoxin injection in the elderly. However, elderly patients are more likely to have age-related kidney or heart problems which may require caution and an adjustment in the dose for patients receiving digoxin injection.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Levoketoconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abrocitinib
• Aceclofenac
• Acemetacin
• Adagrasib
• Albuterol
• Alprazolam
• Amiodarone
• Amlodipine
• Amtolmetin Guacil
• Asciminib
• Aspirin
• Atorvastatin
• Azithromycin
• Bemetizide
• Bendroflumethiazide
• Benzthiazide
• Berotralstat
• Boceprevir
• Bromfenac
• Bufexamac
• Buthiazide
• Calcium
• Canagliflozin
• Cannabidiol
• Capmatinib
• Captopril
• Carvedilol
• Celecoxib
• Ceritinib
• Chan Su
• Chlorothiazide
• Chlorthalidone
• Choline Salicylate
• Cinnarizine
• Clarithromycin
• Clevidipine
• Clonixin
• Clopamide
• Cobicistat
• Colchicine
• Conivaptan
• Crizotinib
• Cyclopenthiazide
• Cyclosporine
• Cyclothiazide
• Daclatasvir
• Daridorexant
• Darunavir
• Demeclocycline
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Diltiazem
• Dipyrone
• Dofetilide
• Dopamine
• Doxercalciferol
• Dronedarone
• Droxicam
• Elacestrant
• Elagolix
• Eliglustat
• Ephedrine
• Epinephrine
• Erdafitinib
• Erythromycin
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Felodipine
• Fenoprofen
• Fepradinol
• Feprazone
• Fingolimod
• Floctafenine
• Flufenamic Acid
• Fluoxetine
• Flurbiprofen
• Gentamicin
• Gilteritinib
• Hawthorn
• Hydrochlorothiazide
• Hydroflumethiazide
• Ibuprofen
• Indapamide
• Indomethacin
• Isavuconazonium Sulfate
• Isradipine
• Itraconazole
• Ivacaftor
• Ketoprofen
• Ketorolac
• Kyushin
• Lapatinib
• Lasmiditan
• Ledipasvir
• Lenacapavir
• Lily of the Valley
• Lorlatinib
• Lornoxicam
• Loxoprofen
• Lumacaftor
• Lumiracoxib
• Magnesium Sulfate
• Manidipine
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Methyclothiazide
• Metoclopramide
• Metolazone
• Mifepristone
• Milnacipran
• Minocycline
• Mitapivat
• Moricizine
• Morniflumate
• Nabumetone
• Naproxen
• Nefazodone
• Nepafenac
• Neratinib
• Nicardipine
• Nifedipine
• Niflumic Acid
• Nilvadipine
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Nimodipine
• Nirmatrelvir
• Nisoldipine
• Nitrendipine
• Norepinephrine
• Octreotide
• Oleander
• Omeprazole
• Oxaprozin
• Oxyphenbutazone
• Oxytetracycline
• Parecoxib
• Paroxetine
• Pheasant's Eye
• Phenylbutazone
• Phenytoin
• Piketoprofen
• Piroxicam
• Pirtobrutinib
• Polythiazide
• Ponesimod
• Potassium Phosphate
• Pranoprofen
• Proglumetacin
• Propafenone
• Propantheline
• Propyphenazone
• Proquazone
• Quinethazone
• Quinidine
• Quinine
• Rabeprazole
• Ranolazine
• Rifampin
• Ritonavir
• Rofecoxib
• Rolapitant
• Salicylic Acid
• Salsalate
• Saquinavir
• Selpercatinib
• Simeprevir
• Simvastatin
• Siponimod
• Sodium Salicylate
• Sotagliflozin
• Sotalol
• Sotorasib
• Sparsentan
• Spironolactone
• Squill
• Succinylcholine
• Sulindac
• Taurursodiol
• Telaprevir
• Telmisartan
• Tenoxicam
• Tepotinib
• Teriparatide
• Tetracycline
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Tolvaptan
• Tramadol
• Trichlormethiazide
• Trimethoprim
• Tucatinib
• Valbenazine
• Valdecoxib
• Vandetanib
• Vemurafenib
• Venetoclax
• Verapamil
• Vibegron
• Vilazodone
• Voclosporin
• Vonoprazan
• Xipamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol
• Arbutamine
• Arotinolol
• Atenolol
• Azosemide
• Befunolol
• Bepridil
• Betaxolol
• Bevantolol
• Bisoprolol
• Bopindolol
• Bucindolol
• Bupranolol
• Bupropion
• Canrenoate
• Carteolol
• Cascara Sagrada
• Celiprolol
• Chloroquine
• Dilevalol
• Disopyramide
• Epoprostenol
• Esmolol
• Etravirine
• Exenatide
• Flecainide
• Flibanserin
• Gatifloxacin
• Glecaprevir
• Hydroxychloroquine
• Indecainide
• Labetalol
• Landiolol
• Lenalidomide
• Levobunolol
• Mepindolol
• Metipranolol
• Metoprolol
• Mibefradil
• Miglitol
• Mirabegron
• Nadolol
• Nebivolol
• Oxprenolol
• Pancuronium
• Penbutolol
• Pibrentasvir
• Pindolol
• Practolol
• Propranolol
• Rifapentine
• Roxithromycin
• Sulfasalazine
• Talinolol
• Telithromycin
• Tertatolol
• Ticagrelor
• Timolol
• Trazodone
• Velpatasvir

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• AV block (type of abnormal heart rhythm), with no pacemaker or
• Heart disease (eg, amyloid heart disease, constrictive pericarditis, cor pulmonale, hypertrophic or restrictive cardiomyopathy) or
• Hypercalcemia (high calcium in the blood) or
• Hypokalemia (low potassium in the blood) or
• Hypomagnesemia (low magnesium in the blood) or
• Sick sinus syndrome (type of abnormal heart rhythm), with no pacemaker or
• Wolff-Parkinson-white syndrome (heart rhythm problem)—Use with caution. May make these conditions worse.

• Blood vessel disease (eg, arteriovenous shunt) or
• Diarrhea, chronic or
• Hypocalcemia (low calcium in the blood) or
• Hypoxia (low oxygen in the blood) or
• Thyroid disease—Use with caution. Patients with these conditions may be less sensitive or resistant to the effects of digoxin injection.

• Electrical cardioversion (a medical procedure)—Dose of digoxin injection may be reduced 1 to 2 days prior to electrical cardioversion of atrial fibrillation to avoid worsening of the condition.

• Heart attack—Use of digoxin is not recommended in patients with this condition.

• Kidney disease—Use with caution. The effects may be increased because of slower removal from the body.

• Ventricular fibrillation (heart rhythm problem)—Should not be used in patients with this condition.