Proper Use

Drug information provided by: Merative, Micromedex®

Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take this medicine with food 30 minutes after you eat. Take this medicine the same time each day.

Swallow the tablet whole with water. Do not cut, crush, or chew it. If the tablet must be cut or crushed, it should be done by a pharmacist.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For breast cancer:
      • For patients receiving this alone:
        • Adults—Dose is based on body size and must be determined by your doctor. 1000 to 1250 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle. Your doctor may adjust your dose as needed and tolerated.
        • Children—Use and dose must be determined by your doctor.
      • For patients receiving this in combination with docetaxel:
        • Adults—Dose is based on body size and must be determined by your doctor. 1000 to 1250 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle.
        • Children—Use and dose must be determined by your doctor.
    • For colon cancer:
      • For patients receiving this alone:
        • Adults—Dose is based on body size and must be determined by your doctor. 1250 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle for a maximum of 8 cycles.
        • Children—Use and dose must be determined by your doctor.
      • For patients receiving this in combination with oxaliplatin:
        • Adults—Dose is based on body size and must be determined by your doctor. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle for a maximum of 8 cycles.
        • Children—Use and dose must be determined by your doctor.
    • For colorectal cancer:
      • For patients receiving this alone:
        • Adults—Dose is based on body size and must be determined by your doctor. 1250 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle.
        • Children—Use and dose must be determined by your doctor.
      • For patients receiving this in combination with oxaliplatin:
        • Adults—Dose is based on body size and must be determined by your doctor. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle.
        • Children—Use and dose must be determined by your doctor.
    • For rectal cancer:
      • For patients receiving this with radiation therapy:
        • Adults—Dose is based on body size and must be determined by your doctor. 825 milligrams (mg) per square meter (m(2)) 2 times a day.
        • Children—Use and dose must be determined by your doctor.
      • For patients receiving this without radiation therapy:
        • Adults—Dose is based on body size and must be determined by your doctor. 1250 milligrams (mg) per square meter (m(2)) 2 times a day.
        • Children—Use and dose must be determined by your doctor.
    • For gastric, esophageal, or gastroesophageal junction cancer:
      • For patients receiving this platinum-containing chemotherapy:
        • Adults—Dose is based on body size and must be determined by your doctor. 625 milligrams (mg) per square meter (m(2)) 2 times a day on days 1 to 21 of 21-day cycle for a maximum of 8 cycles.
        • Children—Use and dose must be determined by your doctor.
      • For patients receiving this in combination with oxaliplatin:
        • Adults—Dose is based on body size and must be determined by your doctor. 850 to 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle. Your doctor may adjust your dose as needed and tolerated.
        • Children—Use and dose must be determined by your doctor.
      • For patients receiving this in combination with cisplatin and trastuzumab:
        • Adults—Dose is based on body size and must be determined by your doctor. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle.
        • Children—Use and dose must be determined by your doctor.
    • For pancreatic cancer:
      • For patients receiving this alone:
        • Adults—Dose is based on body size and must be determined by your doctor. 830 milligrams (mg) per square meter (m(2)) 2 times a day for the first 21 days of each 28-day cycle.
        • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you vomit after taking a dose, do not take an extra dose. Take the next dose at the regular time.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.