Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Swelling of the ankles or feet

Less common

  1. Chest tightness
  2. difficult or labored breathing
  3. dizziness
  4. fast, irregular, pounding, or racing heartbeat or pulse
  5. feeling of warmth
  6. redness of the face, neck, arms, and occasionally, upper chest


  1. Black, tarry stools
  2. bleeding gums
  3. blistering, peeling, or loosening of the skin
  4. blood in the urine or stools
  5. blurred vision
  6. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  7. chest pain or discomfort
  8. chills
  9. cold and clammy skin
  10. cold sweats
  11. confusion
  12. cough
  13. dark yellow urine
  14. diarrhea
  15. dilated neck veins
  16. dizziness or lightheadedness when getting up from a lying or sitting position
  17. extra heartbeats
  18. fainting
  19. fever
  20. itching of the skin
  21. joint or muscle pain
  22. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  23. numbness and tingling of the face, fingers, or toes
  24. pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
  25. painful or difficult urination
  26. pale, bluish-colored, or cold hands or feet
  27. pinpoint red or purple spots on the skin
  28. red, irritated eyes
  29. redness of the face, neck, arms, and occasionally, upper chest
  30. redness, soreness or itching skin
  31. shakiness in the legs, arms, hands, or feet
  32. slow or irregular heartbeat
  33. sore throat
  34. sores, ulcers, or white spots on the lips or in the mouth
  35. sores, welting, or blisters
  36. sudden sweating
  37. sweating
  38. swelling of the face, fingers, feet, or lower legs
  39. swollen glands
  40. trembling or shaking of the hands or feet
  41. unsteadiness or awkwardness
  42. unusual bleeding or bruising
  43. unusual tiredness or weakness
  44. weak or absent pulses in the legs
  45. weakness in the arms, hands, legs, or feet
  46. weight gain
  47. yellow eyes or skin

Incidence not known

  1. Clay-colored stools
  2. difficulty with speaking
  3. drooling
  4. headache
  5. loss of appetite
  6. loss of balance control
  7. muscle trembling, jerking, or stiffness
  8. nausea
  9. rash
  10. shuffling walk
  11. stomach pain
  12. twisting movements of the body
  13. uncontrolled movements, especially of the face, neck, and back
  14. unpleasant breath odor
  15. vomiting of blood
  16. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Acid or sour stomach
  2. belching
  3. feeling of warmth
  4. heartburn
  5. indigestion
  6. lack or loss of strength
  7. muscle cramps
  8. redness of the face, neck, arms, and occasionally, upper chest
  9. sleepiness or unusual drowsiness
  10. stomach discomfort, upset, or pain


  1. Abnormal dreams
  2. anxiety
  3. back pain
  4. bad unusual or unpleasant (after) taste
  5. bleeding gums
  6. blistering, crusting, irritation, itching, or reddening of the skin
  7. bloating
  8. bloody nose
  9. burning feeling in the chest or stomach
  10. burning while urinating
  11. burning, dry, or itching eyes
  12. change in color of the treated skin
  13. change in sense of smell
  14. change in taste
  15. changes in vision
  16. constipation
  17. continuing ringing or buzzing or other unexplained noise in the ears
  18. cracked, dry, or scaly skin
  19. decreased sexual performance or desire
  20. depression
  21. difficulty with moving
  22. difficulty with swallowing
  23. discharge, excessive tearing
  24. double vision
  25. dry mouth
  26. dryness of the skin
  27. excess air or gas in the stomach or intestines
  28. excessive muscle tone
  29. eye pain
  30. feeling of constant movement of self or surroundings
  31. feeling of unreality
  32. feeling unusually cold
  33. flushed, dry skin
  34. fruit-like breath odor
  35. full feeling
  36. general feeling of discomfort or illness
  37. hair loss or thinning of the hair
  38. headache, severe and throbbing
  39. hearing loss
  40. increased appetite
  41. increased hunger
  42. increased sweating
  43. increased thirst
  44. increased urge to urinate during the night
  45. increased urination
  46. irritability
  47. irritation in the mouth
  48. lack of feeling or emotion
  49. loose stools
  50. loss of memory
  51. muscle pains, stiffness, tension, tightness, or weakness
  52. nervousness
  53. pain
  54. pains in the stomach, side, or abdomen, possibly radiating to the back
  55. passing gas
  56. problems with memory
  57. redness and swelling of the gums
  58. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  59. restlessness
  60. runny nose
  61. seeing double
  62. sensation of spinning
  63. sense of detachment from self or body
  64. shakiness and unsteady walk
  65. shivering
  66. sneezing
  67. stuffy nose
  68. sweating
  69. swollen joints
  70. tenderness in the stomach area
  71. thirst
  72. trouble in holding or releasing urine
  73. trouble sleeping
  74. twitching
  75. uncaring
  76. unexplained weight loss
  77. unsteadiness, trembling, or other problems with muscle control or coordination
  78. waking to urinate at night
  79. weight loss

Incidence not known

  1. Swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.