متلازمة فترة QT الطويلة

23 سبتمبر 2026

الأبحاث

يعكف الباحثون في مايو كلينك على دراسة طرق جديدة لاكتشاف متلازمة فترة QT الطويلة والأسباب الأخرى للوفاة المفاجئة وتشخيصها وعلاجها. وقد درس فريق الأبحاث في مايو الخصائص الوراثية المسببة لمتلازمة فترة QT الطويلة على نطاق واسع. وتشمل الموضوعات البحثية الحديثة استخدام الذكاء الاصطناعي وتشخيص متلازمة فترة QT الطويلة باستخدام تخطيط كهربية القلب عن بُعد.

اقرأ المزيد عن أبحاث متلازمة فترة QT الطويلة التي تُجري في مختبر Windland Smith Rice لأبحاث جينوم الموت المفاجئ، وفي مركز أبحاث القلب والأوعية الدموية في مايو كلينك.

المنشورات

راجع قائمة المنشورات التي أعدّها أطباء مايو كلينك حول متلازمة فترة QT الطويلة على محرك البحث PubMed، وهي خدمة تقدمها المكتبة الوطنية الأمريكية للطب.

  1. What is long QT syndrome? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/long-qt-syndrome. Accessed March 13, 2024.
  2. Conduction disorders. American Heart Association. https://www.heart.org/en/health-topics/arrhythmia/about-arrhythmia/conduction-disorders. Accessed March 13, 2024.
  3. Schwartz PJ, et al. Congenital long QT syndrome: Epidemiology and clinical manifestations. https://www.uptodate.com/contents/search. Accessed March 13, 2024.
  4. Giudicessi JR, et al. Prevalence and clinical phenotype of concomitant long QT syndrome and arrhythmogenic bileaflet mitral valve prolapse. International Journal of Cardiology. 2019; doi:10.1016/j.ijcard.2018.09.046.
  5. Berul CI. Acquired long QT syndrome: Definitions, pathophysiology, and causes. https://www.uptodate.com/contents/search. Accessed March 13, 2024.
  6. Waddell-Smith KE, et al. Pre-test probability and genes and variants of uncertain significance in familial long QT syndrome. Heart, Lung and Circulation. 2020; doi:10.1016/j.hlc.2019.
  7. AskMayoExpert. Significance of a long QT interval (adult). Mayo Clinic; 2020.
  8. How the heart works. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/heart. Accessed March 13, 2024.
  9. AskMayoExpert. Prolonged QT interval: Signs and symptoms (adult). Mayo Clinic; 2020.
  10. Arrhythmia. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/arrhythmias. Accessed March 13, 2024.
  11. Schwartz PJ, et al. Congenital long QT syndrome: Diagnosis. https://www.uptodate.com/contents/search. Accessed March 13, 2024.
  12. Ferri FF. Long QT syndrome. In: Ferri's Clinical Advisor 2022. Elsevier; 2022. https://www.clinicalkey.com. Accessed March 13, 2024.
  13. Schwartz PJ, et al. Congenital long QT syndrome: Treatment. https://www.uptodate.com/contents/search. Accessed March 13, 2024.
  14. Bos JM, et al. Use of artificial intelligence and deep neural networks in evaluation of patients with electrocardiographically concealed long QT syndrome from the surface 12-lead electrocardiogram. JAMA Cardiology. 2021; doi:10.1001/jamacardio.2020.7422.
  15. Amedro P, et al. Health-related quality of life and physical activity in children with inherited cardiac arrhythmia or inherited cardiomyopathy: The prospective multicentre controlled QUALIMYORYTHM study rationale, design and methods. Health and Quality of Life Outcomes. 2021; doi:10.1186/s12955-021-01825-6.
  16. Ami TR. Allscripts EPSi. Mayo Clinic. March 29, 2024.
  17. Giudicessi JR, et al. Artificial intelligence-enabled assessment of the heart rate corrected QT interval using a mobile electrocardiogram device. Circulation. 2021; doi:10.1161/CIRCULATIONAHA.120.050231.
  18. Mayo Clinic Laboratories. Test ID: LQTSG. https://www.mayocliniclabs.com/test-catalog/overview/617351. Accessed March 15, 2024.
  19. Bos JM, et al. Mexiletine shortens the QT interval in patients with potassium channel-mediated type 2 long QT syndrome. Circulation. 2019; doi:10.1161/CIRCEP.
  20. Cuneo BF, et al. Mothers with long QT syndrome are at increased risk for fetal death: Findings from a multicenter international study. American Journal of Obstetrics and Gynecology. 2020; doi:10.1016/j.ajog.2019.09.004.
  21. Tobert KE, et al. Return-to-play for athletes with long QT syndrome or genetic heart diseases predisposing to sudden death. Journal of the American College of Cardiology. 2021; doi:10.1016/j.jacc.2021.04.026.
  22. Schwartz PJ, et al. Inherited cardiac arrhythmias. Nature Reviews: Disease Primer. 2020; doi:10.1038/s41572-020-0188-7.
  23. Al-Khatib SM, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2018; doi:10.1161/CIR.0000000000000549.
  24. Medical review (expert opinion). Mayo Clinic. May 1, 2020.
  25. Electrocardiogram. Mayo Clinic. https://www.mayoclinic.org/tests-procedures/ekg/about/pac-20384983. Accessed March 13, 2024.
  26. Medical review (expert opinion). Mayo Clinic. May 1, 2020.
  27. Long B, et al. Electrocardiographic manifestations of COVID-19. American Journal of Emergency Medicine. 2021; doi:10.1016/j.ajem.2020.12.060.
  28. AskMayoExpert. Evaluation of significant QT prolongation and/or serial QT lengthening (adult). Mayo Clinic; 2020.