Phenylalanine isn't a health concern for most people. However, for people who have the genetic disorder phenylketonuria (PKU) or certain other health conditions, phenylalanine can be a serious health concern.
Phenylalanine can cause mental retardation, brain damage, seizures and other problems in people with PKU. Phenylalanine occurs naturally in many protein-rich foods, such as milk, eggs and meat. Phenylalanine also is sold as a dietary supplement.
The artificial sweetener aspartame (Equal, NutraSweet), which is added to many medications, diet foods and diet sodas, contains phenylalanine. Federal regulations require that any food that contains aspartame bear this warning: "Phenylketonurics: Contains phenylalanine." This warning helps people with PKU avoid products that are a source of phenylalanine.
If you don't have PKU, you probably don't need to worry about harmful health effects of phenylalanine — with certain important exceptions. Aspartame in large doses can cause a rapid increase in the brain levels of phenylalanine. Because of this, use products with aspartame cautiously if you:
- Take certain medications, such as monoamine oxidase inhibitors, neuroleptics or medications that contain levodopa
- Have tardive dyskinesia
- Have a sleep disorder
- Have an anxiety disorder or other mental health condition
If you aren't sure if phenylalanine or aspartame is a concern for you, talk to your doctor.
Nov. 27, 2012
See more Expert Answers
- Bodamer OA, et al. Overview of phenylketonuria. http://www.uptodate.com/index. Accessed Aug. 20, 2012.
- Phenylketonuria. National Human Genome Research Institute. http://www.genome.gov/25020037. Accessed Sept. 18, 2012.
- Position of the Academy of Nutrition and Dietetics: Use of nutritive and nonnutritive sweeteners. Journal of the Academy of Nutrition and Dietetics. 2012;112:739.
- Aspartame.Electronic Code of Federal Regulations. http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&sid=e057b68f0345a6d44b25b082c07ffa91&rgn=div8&view=text&node=21:22.214.171.124.126.96.36.199&idno=21. Accessed Aug. 20, 2012.
- Zeratsky KA (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 20, 2012.
- Phenylalanine. Lexi-Interact. Lexi-Comp. http://www.uptodate.com/crlsql/interact/frameset.jsp. Accessed Aug. 20, 2012.
- Magnuson BA, et al. Aspartame: A safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Critical Reviews in Toxicology. 2007;37:629.