Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Risperdal Consta

Descriptions


Risperidone injection is used to treat the symptoms of psychotic (mental) disorders, such as schizophrenia. It may be used alone or together with other medicines (e.g., lithium or valproate) to treat patients with bipolar disorder. This medicine should not be used to treat behavioral problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Suspension, Extended Release

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of risperidone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Elderly people may be especially sensitive to the effects of risperidone. This may increase the chance of having side effects during treatment. This medicine should not be used for behavioral problems in older adults with dementia.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of risperidone injection in the elderly. However, elderly patients are more likely to have age-related heart problems, which may require caution and an adjustment in the dose for patients receiving risperidone injection.

Pregnancy

Information about this risperidone-intramuscular-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Bepridil
  • Cisapride
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Terfenadine
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Bretylium
  • Bupropion
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Citalopram
  • Clarithromycin
  • Crizotinib
  • Desipramine
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Doxepin
  • Droperidol
  • Encainide
  • Enflurane
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Gemifloxacin
  • Ginkgo Biloba
  • Halofantrine
  • Haloperidol
  • Hydromorphone
  • Hydroquinidine
  • Ibutilide
  • Imipramine
  • Ivabradine
  • Linezolid
  • Lithium
  • Lorcainide
  • Mefloquine
  • Milnacipran
  • Nortriptyline
  • Octreotide
  • Ondansetron
  • Pazopanib
  • Pentamidine
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Sematilide
  • Sertindole
  • Simvastatin
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Tedisamil
  • Telithromycin
  • Tetrabenazine
  • Tramadol
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Vemurafenib
  • Vinflunine
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Cimetidine
  • Fosphenytoin
  • Itraconazole
  • Ketoconazole
  • Lamotrigine
  • Midodrine
  • Paroxetine
  • Phenobarbital
  • Phenytoin
  • Ranitidine
  • Ritonavir
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alzheimer's disease or
  • Dehydration or
  • Heart attack, recent or history of or
  • Heart or blood vessel disease or
  • Heart failure, history of or
  • Heart rhythm problem, or a history of or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low amount of blood) or
  • Stroke, history of or
  • Trouble with swallowing—May cause side effects to become worse.
  • Blood or bone marrow problems or
  • Bone problems (e.g., osteodystrophy) or
  • Breast cancer, prolactin-dependent or
  • Diabetes or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Neuroleptic malignant syndrome (NMS), history of or
  • Parkinson's disease or
  • Priapism (painful or prolonged erection of the penis) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Brain tumor or
  • Intestinal blockage or
  • Reye's syndrome—Risperidone injection may prevent vomiting and hide these medical problems from you or your doctor.
  • Kidney disease or
  • Liver disease—Effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Stop taking this medicine and check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position suddenly. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Risperidone injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

This medicine may cause drowsiness, trouble with thinking, or trouble with controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

This medicine may make it more difficult for your body to cool itself down. Use care not to become overheated during exercise or hot weather since overheating may result in heat stroke. Also, use extra care not to become too cold while you are taking risperidone injection. If you become too cold, you may feel drowsy, confused, or clumsy.

Risperidone injection may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicines including other narcotics; medicine for seizures (e.g., barbiturates); muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Difficulty with swallowing
  2. drowsiness
  3. inability to sit still
  4. loss of balance control
  5. mask-like face
  6. need to keep moving
  7. relaxed and calm
  8. restlessness
  9. shuffling walk
  10. sleepiness
  11. slowed movements
  12. slurred speech
  13. stiffness of the arms and legs
  14. tic-like (jerky) movements of the head, face, mouth, and neck
  15. trembling and shaking of the fingers and hands

Less common

  1. Abdominal or stomach pain
  2. abnormal or decreased touch sensation
  3. absence of or decrease in body movement
  4. anxiety
  5. back pain
  6. black, tarry, stools
  7. bladder pain
  8. bloating or swelling of the face, arms, hands, lower legs, or feet
  9. bloody or cloudy urine
  10. blurred vision
  11. body aches or pain
  12. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  13. change in walking and balance
  14. changes in patterns and rhythms of speech
  15. chest pain or discomfort
  16. clumsiness or unsteadiness
  17. cold flu-like symptoms
  18. cold sweats
  19. convulsions
  20. cough or hoarseness
  21. cough producing mucus
  22. depression
  23. diarrhea
  24. difficult or labored breathing
  25. difficult, burning, or painful urination
  26. difficulty with breathing
  27. difficulty with moving
  28. disturbed attention
  29. dizziness
  30. dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  31. dry mouth
  32. ear congestion
  33. fainting
  34. fast, irregular, pounding, or racing heartbeat or pulse
  35. fever or chills
  36. flushed, dry skin
  37. frequent urge to urinate
  38. fruit-like breath odor
  39. general feeling of discomfort or illness
  40. hard lump
  41. headache
  42. hyperventilation
  43. inability to move the eyes
  44. increased blinking or spasms of the eyelid
  45. increased hunger
  46. increased thirst
  47. increased urination
  48. irritability
  49. joint pain
  50. lip smacking or puckering
  51. loss of appetite
  52. loss of bladder control
  53. loss of voice
  54. lower back or side pain
  55. muscle aches and pains
  56. muscle stiffness
  57. muscle weakness
  58. nasal congestion
  59. nausea
  60. neck pain
  61. pain
  62. pale skin
  63. pounding in the ears
  64. pounding, slow heartbeat
  65. puffing of the cheeks
  66. rapid or worm-like movements of the tongue
  67. rapid weight gain
  68. shivering
  69. shortness of breath
  70. slow or fast heartbeat
  71. sneezing
  72. sore throat
  73. sticking out of the tongue
  74. stuffy or runny nose
  75. sweating
  76. swelling or puffiness of the face
  77. swollen joints
  78. tightness in the chest
  79. trouble with breathing, speaking, or swallowing
  80. trouble with sleeping
  81. troubled breathing with exertion
  82. ulcers, sores, or white spots in the mouth
  83. uncontrolled chewing movements
  84. uncontrolled twisting movements of the neck, trunk, arms, or legs
  85. unexplained weight loss
  86. unusual bleeding or bruising
  87. unusual facial expressions
  88. unusual tiredness or weakness
  89. unusual weight gain or loss
  90. vomiting
  91. wheezing

Incidence not known

  1. Abnormal growth filled with fluid or semisolid material
  2. accumulation of pus
  3. actions that are out of control
  4. bleeding gums
  5. blood in the urine or stools
  6. bluish lips or skin
  7. break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
  8. change in vision
  9. clay-colored stools
  10. clumsiness
  11. collection of blood under the skin
  12. coma
  13. confusion
  14. constipation
  15. dark urine
  16. deep, dark purple bruise
  17. drowsiness
  18. fever with or without chills
  19. flushed, dry skin
  20. fruit-like breath odor
  21. indigestion
  22. itching
  23. itching, pain, redness, or swelling
  24. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  25. loss of consciousness
  26. low body temperature
  27. not breathing
  28. painful or prolonged erection of the penis
  29. pains in the stomach, side, or abdomen, possibly radiating to the back
  30. pinpoint red spots on the skin
  31. rash
  32. severe constipation
  33. swollen, red, tender area of infection
  34. talking, feeling, and acting with excitement
  35. tiredness
  36. unexplained weight loss
  37. unpleasant breath odor
  38. vomiting of blood
  39. weak or feeble pulse
  40. weight gain
  41. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. belching
  3. heartburn
  4. stomach discomfort, upset, or pain

Less common

  1. Abnormal ejaculation
  2. absent missed or irregular menstrual periods
  3. bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  4. blemishes on the skin
  5. burning, dry, or itching eyes
  6. change in hearing
  7. decreased interest in sexual intercourse
  8. decreased sexual performance or desire
  9. decreased vision
  10. discharge, excessive tearing
  11. dry skin
  12. ear drainage
  13. ear pain
  14. feeling of constant movement of self or surroundings
  15. inability to have or keep an erection
  16. increased watering of the mouth
  17. loss in sexual ability, desire, drive, or performance
  18. pain or tenderness around the eyes and cheekbones
  19. pimples
  20. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  21. sensation of spinning
  22. skin rash, encrusted, scaly and oozing
  23. sleeplessness
  24. sluggishness
  25. stopping of menstrual bleeding
  26. swelling of the breasts or unusual milk production
  27. swelling of the breasts or breast soreness in both females and males
  28. tender, swollen glands in the neck
  29. tenderness in the stomach area
  30. toothache
  31. unable to sleep
  32. unexpected or excess milk flow from breasts
  33. voice changes
  34. weight gain
  35. weight loss

Incidence not known

  1. Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.