Description and Brand Names

Drug information provided by: Micromedex


Leucovorin is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses. It is used also to prevent or treat certain kinds of anemia. Leucovorin acts the same way in the body as folic acid, which may be low in these patients.

Leucovorin is also used along with fluorouracil (a cancer medicine) to treat cancer of the colon (bowel).

Leucovorin is available only with a prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in the product labeling, leucovorin is used in certain patients with the following medical conditions:

  • Ewing's sarcoma (type of cancer found in the bone)
  • Gestational trophoblastic tumors (tumors in the uterus or womb)
  • Head and neck cancer
  • Non-Hodgkin's lymphoma (cancer of the lymph system)

This product is available in the following dosage forms:

  • Tablet
  • Powder for Solution
  • Solution
  • Injectable