Proper Use

Drug information provided by: Micromedex

Dilaudid-HP® injection should only be used by patients who have already been taking narcotic pain medicines, also called opioids. These patients are called opioid-tolerant. If you are uncertain whether or not you are opioid-tolerant, check with your doctor before using this medicine.

A nurse or other trained health professional will give you this medicine in a hospital. This medicine may be given as a shot under the skin, as a shot into one of your muscles, or through a needle placed in one of your veins.

Hydromorphone injection may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your doctor will teach you how to prepare and inject the medicine. Be sure that you understand exactly how the medicine is prepared and injected.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

Use a new needle and syringe each time you inject your medicine.

If the medicine in the vial or ampule has changed color, or if you see particles in it, do not use it.

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection (intramuscular or subcutaneous) dosage forms:
    • For moderate to severe pain:
      • For patients who are not taking opioid medicines (not opioid-tolerant):
        • Adults—At first, 1 to 2 milligrams (mg) injected under your skin or into one of your muscles every 2 to 3 hours as needed. Your doctor may adjust your dose as needed and tolerated.
        • Children—Use and dose must be determined by your doctor.
      • For patients who are already taking opioid medicines (opioid-tolerant):
        • Adults—Your dose is the same as your dose of Dilaudid® or your doctor will determine your dose based on the narcotic pain medicine you are already receiving.
        • Children—Use and dose must be determined by your doctor.

Missed Dose

Call your doctor or pharmacist for instructions.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

If you store this medicine at home, keep it at room temperature, away from heat and direct light.

Flush all leftover medicine down the toilet after you have finished your treatment. Also, flush old medicine after the expiration date has passed. This medicine is one of only a few medicines that should be disposed of this way.