Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Cytoxan
  2. Cytoxan Lyophilized


Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, cyclophosphamide is used in certain patients with the following medical conditions:

  • Cancer of the adrenal cortex (the outside layer of the adrenal gland).
  • Cancer of the bladder.
  • Cancer in the bones.
  • Cancer of the cervix.
  • Cancer of the endometrium.
  • Cancers of the lungs.
  • Cancer of the prostate.
  • Cancer of the testicles.
  • Ewing's sarcoma (a certain type of bone cancer).
  • Germ cell tumors in the ovaries (a cancer in the egg-making cells in the ovary).
  • Gestational trophoblastic tumors (a certain type of tumor in the uterus/womb).
  • Histiocytosis X (a type of cancer found mainly in children).
  • Organ transplant rejection (prevention).
  • Rheumatoid arthritis.
  • Soft tissue sarcomas (a cancer of the muscles, tendons, vessels that carry blood or lymph, joints, and fat).
  • Systemic dermatomyositis.
  • Systemic lupus erythematosus.
  • Thymoma (a cancer in the thymus, a small organ beneath the breastbone).
  • Tumors in the brain
  • Waldenström's macroglobulinemia (a certain type of cancer of the blood).
  • Wegener's granulomatosis.
  • Wilms' tumor (a cancer of the kidney found primarily in children).

This product is available in the following dosage forms:

  • Powder for Solution
  • Tablet
  • Capsule