Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Taclonex
  2. Taclonex Scalp


Betamethasone and calcipotriene combination is used on the skin and scalp to treat plaque psoriasis.

Betamethasone is a corticosteroid (cortisone-like medicine or steroid). It helps relieve redness, pain, itching, swelling, or other discomfort caused by certain skin problems.

Calcipotriene is a form of Vitamin D. It works by changing how the skin cells are produced in the areas affected by psoriasis.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Ointment
  • Suspension

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of betamethasone and calcipotriene combination in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of betamethasone and calcipotriene combination in the elderly.


Information about this betamethasone-and-calcipotriene-topical-application-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aldesleukin
  • Bupropion
  • Insulin Degludec
  • Itraconazole
  • Pixantrone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alatrofloxacin
  • Alcuronium
  • Aspirin
  • Atracurium
  • Balofloxacin
  • Cinoxacin
  • Ciprofloxacin
  • Clinafloxacin
  • Desogestrel
  • Dienogest
  • Drospirenone
  • Enoxacin
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etonogestrel
  • Fleroxacin
  • Flumequine
  • Fosphenytoin
  • Gallamine
  • Gemifloxacin
  • Grepafloxacin
  • Hexafluorenium
  • Levofloxacin
  • Levonorgestrel
  • Licorice
  • Lomefloxacin
  • Medroxyprogesterone Acetate
  • Mestranol
  • Metocurine
  • Moxifloxacin
  • Norelgestromin
  • Norethindrone
  • Norfloxacin
  • Norgestimate
  • Norgestrel
  • Ofloxacin
  • Pefloxacin
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Prulifloxacin
  • Rifampin
  • Rifapentine
  • Rosoxacin
  • Rufloxacin
  • Saiboku-To
  • Sparfloxacin
  • Temafloxacin
  • Tosufloxacin
  • Trovafloxacin Mesylate

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Atrophy (thin skin) at the site to be treated or
  • Cushing's syndrome (adrenal gland disorder) or
  • Diabetes or
  • Hyperglycemia (high blood sugar) or
  • Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.
  • Erythrodermic (redness), exfoliative (peeling), or pustular (with pus) psoriasis or
  • Hypercalcemia (high calcium in the blood) or
  • Hypercalciuria (high calcium in the urine) or
  • Kidney disease, severe or
  • Liver disease, severe—Use has not been studied in patients with these conditions. .
  • Infection of the skin or scalp at or near the place of application or
  • Large sores, broken skin, or severe skin injury at the place of application or
  • Liver failure—The chance of side effects may be increased.

Proper Use

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

This medicine should only be used on the skin or scalp only. Do not get it in your eyes, nose, mouth, vagina, or apply it on your face, under your arms, or on your groin area. Do not use it on skin or scalp areas that have cuts or scrapes. If it does get on these areas, rinse it off right away with water.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

To help clear up your skin or scalp problem completely, it is very important that you keep using this medicine for the full time of treatment. Do not miss any doses.

This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other skin conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

The treated areas should not be bandaged or covered after the medicine is applied.

To use the ointment:

  • Wash your hands with soap and water before and after using this medicine.
  • Apply a thin layer to the affected areas of the skin and rub it in gently.
  • Do not use the ointment for more than 8 weeks unless your doctor has told you to.

To use the topical liquid:

  • Wash your hands with soap and water before and after using this medicine.
  • Shake the bottle before using the medicine.
  • Part your hair so you can see the patches on your scalp.
  • Apply enough medicine to the affected areas on your scalp and rub it in gently.
  • Do not wash your hair or take a bath or shower right after applying this medicine.
  • Do not apply this medicine in the 12 hours before or after using any hair chemical treatments. Talk with your doctor first about it.
  • Do not use the topical liquid for more than 8 weeks unless your doctor has told you to.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For psoriasis:
    • For topical dosage form (ointment):
      • Adults—Apply to the affected area of the skin once a day. Treatment may be continued for up to 4 weeks or as determined by your doctor.
      • Children—Use and dose must be determined by your doctor.
    • For topical dosage form (suspension):
      • Adults—Apply to the affected area on the scalp once a day for up to 8 weeks or until the area is cleared or as determined by your doctor.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep the bottle of topical liquid in the carton when not in use. Use it within 6 months after it has been opened.


It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood, urine, and other tests may be needed to check for unwanted effects.

If your psoriasis does not improve within a few weeks or become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor if you have more than one of these symptoms while you are using this medicine: darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause too much calcium to build up in your body. Talk to your doctor if you have more than one of these symptoms while you are using this medicine: abdominal or stomach pain, confusion, constipation, depression, dry mouth, headache, incoherent speech, increased urination, loss of appetite, a metallic taste, muscle weakness, nausea, thirst, unusual tiredness, vomiting, or weight loss.

Check with your doctor right away if you have a blistering, burning, crusting, dryness, flaking, itching, scaling, severe redness, soreness, or swelling of skin.

Make sure your doctor knows if you are also having ultraviolet (UV) light treatments (phototherapy) for your psoriasis before using this medicine.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen and wear protective clothing when you are outdoors. Avoid sunlamps and tanning beds.

Do not use cosmetics or other skin care products on the treated areas.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  1. Burning, itching, and pain in hairy areas
  2. burning sensation of the skin
  3. flushing or redness of the skin
  4. itching skin
  5. pus at the root of the hair
  6. red, scaling, or crusted skin
  7. scaly rash
  8. skin irritation
  9. thinning of the skin with easy bruising
  10. unusually warm skin


  1. Body aches or pain
  2. chills
  3. cough
  4. darkening of the skin
  5. diarrhea
  6. difficulty in breathing
  7. ear congestion
  8. fever
  9. general feeling of discomfort or illness
  10. headache
  11. joint pain
  12. lightening of normal skin color
  13. lightening of the treated areas of dark skin
  14. loss of appetite
  15. loss of voice
  16. muscle aches and pains
  17. nasal congestion
  18. nausea
  19. raised, dark red, or wart-like spots on skin
  20. red, sore eyes
  21. runny nose
  22. shivering
  23. sneezing
  24. sore throat
  25. spots on your skin that look like a blister or pimple
  26. sweating
  27. trouble sleeping
  28. unusual tiredness or weakness
  29. vomiting
  30. worsening of the psoriasis

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Bruising
  2. large, flat, blue, or purplish patches in the skin
  3. pain


  1. Blemishes on the skin
  2. pimples

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.