Are "bioidentical" or "natural" hormones safer and more effective than hormones used in traditional hormone therapy for menopause symptoms?
Answers from Shannon K. Laughlin-Tommaso, M.D.
No, they aren't. According to the Food and Drug Administration (FDA) and several medical specialty groups, the hormones marketed as "bioidentical" and "natural" aren't safer than hormones used in traditional hormone therapy, and there's no evidence they're any more effective.
The term "bioidentical" means the hormones in the product are chemically identical to those your body produces. In fact, the hormones in bioidentical medications may not be any different from those in traditional hormone therapy. Several hormone therapy products approved by the FDA and prescribed by health care providers contain bioidentical hormones.
"Natural" means the hormones in the product come from plant or animal sources; they're not synthesized in a lab. However, many of these products still need to be commercially processed to become bioidentical. Traditional hormone therapies don't necessarily exclude natural hormones. Some FDA-approved products — such as Estrace, Climara and Vivelle-Dot, which contain estrogens, and Prometrium, a natural progesterone — also are derived from plants.
Marketers of bioidentical hormones say their products have certain advantages over traditional hormone therapy:
- They're produced in doses and forms that differ from those in FDA-approved products. For many nonstandard combinations, you need to go through a compounding pharmacy — one that specializes in making medications customized for your individual needs. However, products from compounding pharmacies haven't been subject to the same rigorous quality assurance standards that standard commercially available hormonal preparations have to meet.
- They're custom made for you, based on a test of your saliva to assess your unique hormonal needs. Unfortunately, however, the hormone levels in your saliva don't reflect the levels in your blood or correspond to menopause symptoms.
Some women may benefit from nonstandard doses and forms of hormones in bioidentical hormone preparations, but there is almost no scientific support for an advantage of these compounds over common commercially produced preparations.
Dec. 05, 2014
Shannon K. Laughlin-Tommaso, M.D.
See more Expert Answers
- Files JA, et al. Bioidentical hormone therapy. Mayo Clinic Proceedings. 2011;86:673.
- Sood R, et al. Counseling postmenopausal women about bioidentical hormones: Ten discussion points for practicing physicians. Journal of the American Board of Family Medicine. 2011;24:202.
- Davis R, et al. Risks and effectiveness of compounded bioidentical hormone therapy: A case series. Journal of Women's Health. 2014;23:642.
- Compounded menopausal hormone therapy questions and answers. Food and Drug Administration. http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/PharmacyCompounding/ucm183088.htm. Accessed Oct. 20, 2014.
- Committee on Gynecologic Practice and the American Society for Reproductive Medicine Practice Committee. Compounded bioidentical menopausal hormone therapy. Obstetrics & Gynecology. 2012;120:411.
- American College of Obstetricians and Gynecologists (ACOG) Committee on Practice Bulletins — Gynecology. ACOG Practice Bulletin No. 141: Management of Menopausal Symptoms. Obstetrics & Gynecology. 2014;123:202.