Familial Mediterranean fever is caused by a gene mutation that's passed from parents to children. The gene mutation causes problems in regulating inflammation in the body.

In people with familial Mediterranean fever, the gene mutation occurs in a gene called MEFV. Many different mutations in MEFV are linked to familial Mediterranean fever. Some mutations may cause very severe cases, while others may be milder.

Familial Mediterranean fever is inherited as an autosomal recessive trait, meaning that you must inherit the mutated gene from both parents in order to develop the condition.

Oct. 09, 2012