Many diseases and conditions can cause an enlarged liver, including:

Liver diseases

  • Cirrhosis
  • Hepatitis caused by a virus — including hepatitis A, B and C — or caused by infectious mononucleosis
  • Nonalcoholic fatty liver disease
  • Alcoholic fatty liver disease
  • A disorder that causes abnormal protein to accumulate in your liver (amyloidosis)
  • A disorder that causes copper to accumulate in your liver (Wilson's disease)
  • A disorder that causes iron to accumulate in your liver (hemachromatosis)
  • A disorder that causes fatty substances to accumulate in your liver (Gaucher's disease)
  • Fluid-filled pockets in the liver (liver cysts)
  • Noncancerous liver tumors, including hemangioma and adenoma
  • Obstruction of the gallbladder or bile ducts
  • Toxic hepatitis

Cancers

  • Cancer that begins in another part of the body and spreads to the liver
  • Leukemia
  • Liver cancer
  • Lymphoma

Heart and blood vessel problems

  • Blockage of the veins that drain the liver (Budd-Chiari syndrome)
  • Heart failure
  • Inflammation of the tissue surrounding the heart (pericarditis)
Apr. 14, 2012