Bone metastasis occurs when cancer cells break away from the original tumor and spread to the bones, where they begin to multiply.
Doctors aren't sure what causes some cancers to spread. And it's not clear why some cancers travel to the bones rather than to other common sites for metastasis, such as the liver.
April 10, 2015
- Walsh D, et al. Palliative Medicine. Philadelphia, Pa.: Saunders Elsevier; 2009. http://www.clinicalkey.com. Accessed Oct. 16, 2014.
- Yu HM, et al. Overview of the epidemiology, clinical presentation, diagnosis, and management of adult patients with bone metastasis. http://www.uptodate.com/home. Accessed Jan. 2, 2015.
- Longo DL, et al. Harrison's Principles of Internal Medicine. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://accessmedicine.mhmedical.com/book.aspx?bookid=331. Accessed Jan. 2, 2015.
- Niederhuber JE, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Oct. 16, 2014.
- Metastatic cancer. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic. Accessed Jan. 2, 2015.
- Rosenthal D, et al. Critical review of the state of the art in interventional oncology: Benign and metastatic disease involving bone. Radiology. 2012;262:765.
- Moynihan TJ (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 11, 2015.