Antiphospholipid syndrome

If you've had episodes of blood clots or pregnancy loss that aren't explained by known health conditions, talk with your healthcare professional. The health professional can schedule blood tests to check for clotting and for the presence of the antibodies associated with antiphospholipid syndrome.

To confirm a diagnosis of antiphospholipid syndrome, the antibodies must appear in your blood at least twice, in tests conducted 12 or more weeks apart.

You can have antiphospholipid antibodies and never have symptoms. A diagnosis of antiphospholipid syndrome is made only when these antibodies cause health problems.

If you have blood clots, the standard first treatment is a combination of blood-thinning medicines. The most common are heparin and warfarin (Jantoven). Heparin is fast acting and delivered via shots, also called injections. Warfarin comes in pill form and takes several days to have an effect. Aspirin also is a blood thinner used to prevent blood clots.

When you're taking blood thinners, you have an increased risk of bleeding episodes. Your healthcare team monitors your dosage with blood tests. This monitoring can help make sure your blood can clot well enough to stop the bleeding of a cut or the bleeding under the skin from a bruise.

There is some evidence that other medicines might be helpful in treating antiphospholipid syndrome. These include hydroxychloroquine (Plaquenil), rituximab (Rituxan), eculizumab (Soliris) and medicines called statins. More study is needed.

Treatment during pregnancy

It's possible to have a successful pregnancy if you have antiphospholipid syndrome, especially with treatment. Treatment often involves heparin or heparin with aspirin. Warfarin isn't given to pregnant women because it can affect the fetus.

Depending on your treatment plan for antiphospholipid syndrome, there may be other steps you can take to protect your health. If you take blood-thinning medicines, take extra care to keep from injuring yourself and to avoid bleeding.

• Avoid contact sports or other activities that could cause bruising or injury or cause you to fall.
• Use a soft toothbrush and waxed floss.
• Shave with an electric razor.
• Take extra care when using knives, scissors and other sharp tools.
• Women should avoid using estrogen therapy for birth control or menopause symptoms.

Food and dietary supplements

Certain foods and medicines may affect how well your blood thinners work. Ask your healthcare professional for guidance about:

• Safe food choices. Vitamin K can lessen the effectiveness of warfarin, but not other blood-thinners. You might need to avoid eating large amounts of vitamin K-rich foods such as avocado, broccoli, Brussels sprouts, cabbage, leafy greens and garbanzo beans. Alcohol can increase warfarin's blood-thinning effect. Ask your healthcare professional if you need to limit or avoid alcohol.
• Safe medicines and dietary supplements. Certain medicines, vitamins and herbal products can interact dangerously with warfarin. These include some pain relievers, cold medicines, upset stomach remedies and multivitamins, as well as garlic, ginkgo and green tea.

Complications of antiphospholipid syndrome — such as DVT, stroke or pregnancy loss — may prompt you to seek medical care. Depending on your complication, you'll likely see a specialist in vascular disease, obstetrics or hematology.

Here's some information to help you get ready for your appointment.

What you can do

Be aware of any restrictions before your appointment. When you make the appointment, ask if there's anything you need to do in advance.

Make a list of:

• Your symptoms and when they began.
• Key personal information, including major recent events or changes in your life.
• Key medical information, including other conditions or infections you have and your family medical history. Tell your health professional about any relatives — such as parents, grandparents or cousins — who have had antiphospholipid syndrome.
• All medicines, vitamins and other supplements you take, including doses.
• Questions to ask your healthcare professional.

Take a family member or friend along, if possible, to help you remember the information you get.

For antiphospholipid syndrome, some questions to ask your healthcare professional include:

• What's the most likely cause of my symptoms?
• What tests do I need?
• What treatment do you recommend?
• How will we know if my treatment is working?
• Does this condition increase my risk of other medical problems?
• Does this condition increase my risk of health problems during pregnancy? Are there treatments to reduce that risk?
• Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions as well.

What to expect from your doctor

Your healthcare professional is likely to ask you a number of questions, including:

• Do you have a history of stroke or blood clots?
• Do you have a history of pregnancy complications, such as high blood pressure, miscarriage or stillbirth?
• Do you have lupus or another autoimmune disease?
• Have you ever been tested for sexually transmitted infections or chronic viral diseases, such as hepatitis?
• Do you have frequent headaches?
• Have you noticed a discolored, netlike rash on your wrists or knees?
• Do you smoke?