If you have one or more episodes of thrombosis or pregnancy loss that are not explained by known health conditions, your doctor can schedule blood tests to check for abnormal clotting and for the presence of antibodies to phospholipid-binding proteins.
Blood tests for antiphospholipid syndrome look for at least one of the following three antibodies in your blood:
- Lupus anticoagulant
- Beta-2 glycoprotein I
To confirm a diagnosis of antiphospholipid syndrome, the antibodies must appear in your blood at least twice, in tests conducted at least 12 weeks apart.
April 15, 2014
- Giannakopoulos B, et al. Pathogenesis of the antiphospholipid syndrome. New England Journal of Medicine. 2013;368:1033.
- What is antiphospholipid antibody syndrome? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/aps/. Accessed Dec. 2, 2013.
- Learning about antiphospholipid syndrome. National Human Genome Research Institute. http://www.genome.gov/pfv.cfm?pageID=17516396. Accessed Dec. 4, 2013.
- Papadakis MA, et al. Current Medical Diagnosis & Treatment 2013. 52nd ed. New York, N.Y.: The McGraw-Hill Companies; 2013. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=1. Accessed Dec. 4, 2013.
- Bermas BL, et al. Pathogenesis of the antiphospholipid syndrome. http://www.uptodate.com/home. Accessed Dec. 5, 2013.
- Donadini MP, et al. Antiphospholipid syndrome: A challenging hypercoagulable state with systemic manifestations. Hematology/Oncology Clinics of North America. 2010;24:669.
- Arnaud L, et al. Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: An international and collaborative meta-analysis. Autoimmunity Reviews. 2013 [In Press]. Accessed Dec. 4, 2013.
- Bermas BL, et al. Treatment of the antiphospholipid syndrome. http://www.uptodate.com/home. Accessed Dec. 4, 2013.
- Lockshin MD. Pregnancy and antiphospholipid syndrome. American Journal of Reproductive Immunology. 2013;69:585.
- Wijetilleka S, et al. Novel insights into pathogenesis, diagnosis and treatment of antiphospholipid syndrome. Current Opinion in Rheumatology. 2012;24:473.
- Arachchillage AJ, et al. Use of new oral anticoagulants in antiphospholipid syndrome. Current Rheumatology Report. 2013;15:331.
- Blood thinner pills: Your guide to using them safely. Rockville, Md.: Agency for Healthcare Research and Quality. http://www.ahrq.gov/consumer/btpills.htm. Accessed Dec. 5, 2013.
- Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Institute of Medicine. http://www.iom.edu/Reports/2001/Dietary-Reference-Intakes-for-Vitamin-A-Vitamin-K-Arsenic-Boron-Chromium-Copper-Iodine-Iron-Manganese-Molybdenum-Nickel-Silicon-Vanadium-and-Zinc.aspx. Accessed Dec. 5, 2013.