Mayo Clinic doctors and surgeons have experience treating people who may benefit from an ABO incompatible kidney transplant. In this type of transplant, your donor's blood type and your blood type aren't compatible.
In the past, if your blood contained antibodies that reacted to your donor's blood type, the antibody reaction would immediately cause you to reject your transplant. This would prevent a successful transplant. Until recently, the only option was to identify recipient-donor transplant pairs with compatible ABO blood types.
Now ABO incompatible kidney transplant is possible between some recipients and living donors. The option of having a living donor with a different blood type may reduce the time on a waiting list.
With ABO incompatible kidney transplant, you receive medical treatment before and after your kidney transplant to lower antibody levels in your blood and reduce the risk of antibodies rejecting the donor kidney. This treatment includes:
- Removing antibodies from your blood (plasmapheresis)
- Injecting antibodies into your body that protect you from infections (intravenous immunoglobulin)
- Providing other medications that protect your new kidney from antibodies
Mayo Clinic researchers were among the first to develop treatments to counteract antibodies to prevent rejection of a donor kidney with an incompatible blood type.
Researchers have also developed treatments to reduce rejection of a donor kidney when a recipient's antibodies react against a donor's tissue and cells (positive crossmatch kidney transplant).
Researchers continue to study the effect of antibodies after transplant and potential treatments to lower antibody levels. The goal of research is to prevent rejection of a donor kidney.
July 14, 2016
- Scientific Registry of Transplant Recipients. http://www.srtr.org/default.aspx. Accessed April 7, 2016.
- U.S. News & World Report. U.S. News Best Hospitals 2015-16. http://health.usnews.com/best-hospitals/rankings. Accessed Feb. 22, 2016.
- Orandi BJ, et al. Kidney transplants from incompatible live donors. New England Journal of Medicine. 2016;374:940.
- Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. April 5, 2016.
- Schinstock CA (expert opinion). Mayo Clinic, Rochester, Minn. April 18, 2014.
- Lallas CD, et al. The development of a laparoscopic donor nephrectomy program in a de novo renal transplant program: Evolution of technique and results in over 200 cases. Journal of the Society of Laparoendoscopic Surgeons. 2006;10:135.
- Mai ML (expert opinion). Mayo Clinic, Jacksonville, Fla. April 26, 2016.
- Stulak JM, et al. Combined heart and abdominal organ transplantation: Excellent outcomes gained from a unique experience. Journal of Heart and Lung Transplantation. 2014;33:S278.
- Li H, et al. Assessing the efficacy of kidney paired donation — Performance of an integrated three-site program. Transplantation. 2014;98:300.
- Cornell LD, et al. Positive crossmatch kidney transplant recipients treated with eculizumab: Outcomes beyond 1 year. American Journal of Transplantation. 2015;15:1293.
- Shapiro R, et al. Benefits and complications of laparoscopic donor nephrectomy. http://www.uptodate.com/home. Accessed March 11, 2016.
- Polycystic kidney disease. National Institutes of Diabetes and Digestive Kidney Diseases. http://kidney.niddk.nih.gov/kudiseases/pubs/polycystic/. Accessed March 16, 2016.
- Raichlin E, et al. Combined heart and kidney transplantation provides an excellent survival and decreases risk of cardiac cellular rejection and coronary allograft vasculopathy. Transplantation Proceedings. 2011;43:1871.
- Heilman RL, et al. Steroid avoidance immunosuppression in low-risk kidney transplant recipients. Transplantation Proceedings. 2005;37:1785.
- Jay CL, et al. Reassessing preemptive kidney transplantation in the United States: Are we making progress? Transplantation. 20165;100:1120. http://www.transplantjournal.com. Accessed April 6, 2016.
- Bentall A, et al. Five-year outcomes in living donor kidney transplants with a positive crossmatch. American Journal of Transplantation. 2013;13:76.
- Prieto M (expert opinion). Mayo Clinic, Rochester, Minn. May 11, 2016.
- Dharnidharka VR, et al. Kidney transplantation in children. New England Journal of Medicine. 2014;371:549.
- Barbara Woodward Lips Patient Education Center. Your child's kidney transplant. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016.
- Kidney transplant team describes current work. Mayovox. 1967;18:24.
- Kudva YC (expert opinion). Mayo Clinic, Rochester, Minn. March 14, 2016.
- Barbara Woodward Lips Patient Education Center. Kidney transplant. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Rossi AP, et al. Evaluation of the potential renal transplant recipient. http://www.uptodate.com/home. Accessed April 6, 2016.
- Cramer CH II (expert opinion). Mayo Clinic, Rochester, Minn. April 27, 2016.
- Li H, et al. The limits of paired donation — Who doesn't get transplanted? American Journal of Transplantation. 2013;13(suppl 5). http://www.atcmeetingsabstracts.com/abstract/limits-of-paired-donation-who-doesn’t-get-transplanted-the/. Accessed April 27, 2016.
- Crespo HS, et al. Kidney transplantation in the septuagenarian. American Journal of Transplantation. 2015;15(suppl 3). http://www.atcmeetingabstracts.com/abstract/kidney-transplantation-in-the-septuagenarian/. Accessed April 27, 2016.
- Taner T, et al. Decreased chronic cellular and antibody-mediated injury in the kidney following simultaneous liver-kidney transplantation. Kidney International. 2016:89:909.
Kidney Transplant Program