Cardiovascular Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Compare the Effectiveness of Different High-intensity Interval Training Programs in Cardiac Rehabilitation

   Rochester, Minn.

   The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. 

2. Hospital Diuretic Therapy and Associated Risk of Heart Failure in Treating Fluid Volume Overload

   Rochester, Minn.

   The objective of this proposal is to assess blood-plasma volume (TBV-PV) status quantitatively in patients with DHF admitted to hospital for volume management, and to determine how effective standard diuretic therapy is in achieving euvolemia and the impact of their quantitated volume status at the time of hospital discharge on heart failure related morality and re-hospitalizations. Thus, to determine if quantitative blood volume analysis could potentially serve as an effective tool to guide more effective in-hospital diuretic therapy to achieve better outcomes in patients hospitalized with clinically identified volume overload.

3. the Mayo Cardiac Sarcoid Registry

   Rochester, Minn., Jacksonville, Fla.

   Aims, purpose, or objectives:

   1. Develop a retrospective registry of patients with cardiac sarcoidosis
   2. Develop a prospective registry of patients with cardiac sarcoidosis
   3. Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry
   4. Determine risk factors for sarcoid involvement of the heart
   5. Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis
   6. Understand the complications of untreated and treated cardiac sarcoidosis

    

4. (FMD Impact Registry) Fibromuscular Dysplasia Findings and Outcomes

   Rochester, Minn.

   To describe the clinical, laboratory, pathologic, imaging findings, therapy and outcomes in all patients with Fibromuscular Dysplasia (FMD) and/or segmental arterial mediolysis evaluated at Mayo Clinic retrospectively (back to 01/01/1990) and prospectively (starting 04/13/2016).

5. A Study to Identify the Genetic Defect(s) in Individuals with Arrhythmogenic Bi-Leaflet Mitral Prolapse (aBiMVP)

   Rochester, Minn.

   The purpose of this study is to elucidate the genetic basis of aBiMVP in hopes of determining novel mechanisms that underlie aBiMVP pathogenesis.

6. A Study to Evaluate the Impact of Menopause on Blood Pressure Regulation During Exercise

   Rochester, Minn.

   The purpose of this study is to determine how menopause influences blood pressure responses during exercise in women.

7. A Study to Evaluate Exercise Capacity and Positive Airway Pressure Impact on Sleep Apnea in Heart Failure

   Rochester, Minn.

   The purpose of this study is to determine the prevalence of Obstructive Sleep Apnea (OSA) in HFpEF, and its clinical and hemodynamic correlates, and to determine the impact of intervention with CPAP therapy on exercise capacity and quality of life in HFpEF patients with OSA.

8. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

   Scottsdale/Phoenix, Ariz.

   Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

9. Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

   Rochester, Minn.

   The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in subjects undergoing cardiac surgery who have risk factors for atrial fibrillation and ischemic stroke.

10. Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

    Rochester, Minn.

    The purpose of this study is to provide expanded access of patisiran to patients with hereditary transthyretin-mediated amyloidosis (hATTR).