医疗专业人员

下面列出了当前开展的临床试验。

根据地点、状态和其他条件对此研究列表进行过滤。

1. Genomic and Environmental Basis of Imperforate Anus

   Rochester, Minn.

   The study aims are to develop a consent-based IRB proposal that will enroll newborns who have imperforate anus.  The proposal will include permission for chart review and database information storage, to develop a database that will include MRN, imperforate anus phenotype, information on other congenital malformations, syndromic diagnosis if available, demographic information, and to develop a biobank of DNA and white blood cell samples from infants with imperforate anus. If patients are undergoing a skin biopsy for a medically indicated reason, cells will be requested.

   Imperforate Anus, also known as anal atresia, is a rare birth defect.  Unable to pass stool through the gastrointestinal tract, this condition can result in death of the newborn and emergency surgery is required once discovered.  More than two thirds of affected infants have other birth defects that include other parts of the gastrointestinal tract, airway, heart, skeleton, kidneys, eyes, or ears. The exact prevalence of imperforate anus in the newborn population is unknown. 

2. A Study To Develop A Patient-reported Outcome Tool For Symptomatic Small Bowel Stricturing Crohn’s Disease (CD)

   Rochester, Minn.

   The purpose of this study is to understand and document the concepts relevant and important to the measurement of signs, symptoms, and related experiences of patients living with stricturing CD for development of a new PRO instrument.

3. A Study To Create A Registry For Patients At High-Risk For Pancreatic Cancer

   Rochester, Minn.

   This study aims to facilitate discovery and validation of tests for early detection in subjects at high risk for pancreatic ductal adenocarcinoma (PDAC). and to facilitate the use of state-of-the-art machine learning-based algorithms that utilize databases and images with the purpose of identifying early stages of pancreatic cancer, as well as people at high-risk.The study also aims to provide a platform for development of an interventional protocol for early detection of PDAC.

4. A Study To Evaluate If New Tests (“biomarkers”) Of Blood, Stool, Pancreas Cyst Fluid, Or Pancreas Juice Can Be Used To Diagnose Malignant Or Pre-malignant Changes In People With Pancreas Cysts

   Rochester, Minn.

   The goal of this protocol is to collect biospecimens in order to prospectively evaluate diagnostic and prognostic performance of MDMs for detection of advanced neoplasia in pancreatic cysts. 

5. A Study to Evaluate Evacuation Mechanisms Using Advanced Brain Imaging

   Rochester, Minn.

   The objective of this study is to compare the central neural circuitry with fMRI (7T) in 30 asymptomatic healthy controls, 30 constipated patients without DD, and 30 constipated patients with DD at rest (functional connectivity analysis), during rectal distention to desire to defecate and urgency, and during evacuation. 

    

    

    

6. Cancer screening practices of individuals with Lynch Syndrome

   Rochester, Minn.

   This is a survey study to describe how women with Lynch syndrome are being screened for gynecologic cancer risk, their perception of cancer risk, and uptake of risk reducing surgery.

7. Validation of Pediatric Inflammatory Bowel Disease Knowledge Questions (Emma)

   Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The aim of this study is to test the validity of the current question database in a large cohort of children with Inflammatory Bowel Disease (IBD) in several pediatric gastroenterology centers. 

8. A Study To Develop A Registry For Outcomes And Predictors In Pouch-Related Disorders

   Rochester, Minn.

   The primary purpose of this study is to create a prospective registry of patients with pouch-related conditions to allow for longitudinal assessment of outcomes at 3, 6 and 12 months after a enrollment with a specific diagnosis (acute pouchitis, CADP, CARP, or CD of the pouch).

9. A Study to Evaluate the Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients

   Jacksonville, Fla.

   The purpose of this study is to establish if abdominal breathing exercises can reduce symptoms associated with reflux.

10. Mayo Clinic Inflammatory Bowel Disease Repository

    Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

    The purpose of this research study is to collect clinical information and human samples from patients with IBD. The data collected will be used to create an organized, accessible resource of human samples for biological research in IBD.