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Rochester, Minn.
The purpose of this study is to establish the clearance rate of sPD-L1 in patients undergoing plasma exchange, and to establish the kinetics of sPD-L1 regeneration in vivo.
The primary purpose of this study is to determine the serum and urine gadolinium reference ranges in patients with normal renal function being administered Gadobutrol for an enhanced MRI exam.
The purpose of this study is to collect, isolate and culture progenitor cells. To determine optimal methods for isolation, culture, transfection, and differentiation of these cells with potential therapeutic uses. To act as a central resource for the investigation of these cells for researchers at the Mayo Clinic.
The primary purpose of this study is to generate pediatric-specific reference ranges that take into account patient sex, age, corrected gestational age, ethnicity, etc., and laboratory variables for various coagulation studies.
The goal of this study is to collect adipose tissue from healthy and disease patients to understand the biology and potential therapeutic use of mesenchymal stem cells. Adipose collection occurs under local anesthesia with an abdominal biopsy that collects about two grams of fat. The fat is used to isolate and grow mesenchymal stem cells. These function of these cells will be tested for their therapeutic potential.
The purpose of this study is to determine the sensitivity, specificity, positive and negative predictive values of molecular detection of microorganisms, detection of microbial proteins and antibodies against microorganisms, and inflammatory markers (e.g., leukocyte esterase, CRP) in synovial fluid for the diagnosis of prosthetic joint infection (PJI).
This research study is being done to help characterize cardiovascular disease and improve diagnostic tests.
OBJECTIVES
To understand the pathogenesis, molecular mechanisms, and disease progression of heritable cardiovascular disease
To evaluate the incidence of occult heritable cardiovascular disease in various populations.
To correlate imaging and pathological phenotype with genotype to the ends described above.
The purpose of this study is to help identify the biology of heart tumors and understand how and why they form.
The purpose of this study is to obtain excess non-malignant submandibular salivary tissues and clinical data from patients undergoing head & neck surgery, and conduct research activities at Mayo Clinic.
The purposes of this study are to determine if patients treated with fluoroquinolone (FQ) antibiotics have depletion of mitochondrial DNA (mtDNA) in buccal swab samples, and whether the degree of depletion correlates with the likelihood of developing FQ-associated toxicity.
2nd arm - An additional group of patients will be enrolled if they previously received FQ antibiotics. appear to be symptomatic and have a previously collected muscle or nerve biopsy for clinical purposes available for this research study.
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