Overview

A kidney transplant is a surgical procedure to place a healthy kidney from a live or deceased donor into a person whose kidneys no longer function properly.

The kidneys are two bean-shaped organs located on either side of the spine just below the rib cage. Each one is about the size of a fist. Their main function is to filter and remove excess waste, minerals and fluid from the blood by producing urine.

When your kidneys lose this filtering ability, harmful levels of fluid and waste accumulate in your body, which can raise your blood pressure and result in kidney failure (end-stage renal disease, which is also known as end-stage kidney disease). End-stage renal disease occurs when the kidneys have lost about 90 percent of their ability to function normally.

Common causes of end-stage renal disease include:

  • Diabetes
  • Chronic, uncontrolled high blood pressure
  • Chronic glomerulonephritis — an inflammation and eventual scarring of the tiny filters within your kidneys (glomeruli)
  • Polycystic kidney disease

People with end-stage renal disease need to have waste removed from their bloodstream via a machine (dialysis) or a kidney transplant to stay alive.

Mayo Clinic's approach

Why it's done

A kidney transplant is often the treatment of choice for kidney failure compared to a lifetime on dialysis. A kidney transplant can treat chronic kidney disease with glomerular filtration rate (GFR, a measure of kidney function) less than or equal to 20 ml/min and end-stage renal disease to help you feel better and live longer.

Compared to dialysis, kidney transplant is associated with:

  • Better quality of life
  • Lower risk of death
  • Fewer dietary restrictions
  • Lower treatment cost

Some people may also benefit from receiving a kidney transplant before needing to go on dialysis, a procedure known as preemptive kidney transplant.

But for certain people with kidney failure, a kidney transplant may be more risky than dialysis. Conditions that may prevent you from being eligible for a kidney transplant include:

  • Advanced age
  • Severe heart disease
  • Active or recently treated cancer
  • Poorly controlled mental illness
  • Dementia
  • Alcohol or drug abuse
  • Any other factor that could affect their ability to safely undergo the procedure and take the medications needed to prevent organ rejection

Only one donated kidney is needed to replace two failed kidneys, making living-donor kidney transplantation an option.

If a compatible living donor isn't available, your name may be placed on a kidney transplant waiting list to receive a kidney from a deceased donor.

How long you have to wait for a deceased donor organ depends on the degree of matching or compatibility between you and the donor, time on dialysis and expected survival post-transplant. Some people get a match within several months and others may wait several years.

Risks

Kidney transplantation can treat advanced kidney disease and kidney failure, but it is not a cure. Some forms of kidney disease may return after transplant.

The health risks associated with kidney transplant include those associated directly with the surgery itself, rejection of the donor organ and side effects of taking medications (anti-rejection or immunosuppressants) needed to prevent your body from rejecting the donated kidney.

Deciding whether kidney transplant is right for you is a personal decision that deserves careful thought and consideration of the serious risks and benefits. Talk through your decision with your friends, family and other trusted advisors.

Complications of the procedure

Kidney transplant surgery carries a risk of significant complications, including:

  • Blood clots
  • Bleeding
  • Leaking from or blockage of the tube (ureter) that links the kidney to the bladder
  • Infection
  • Failure of the donated kidney
  • Rejection of the donated kidney
  • An infection or cancer that can be transmitted with the donated kidney
  • Death, heart attack and stroke

Anti-rejection medication side effects

After a kidney transplant, you'll take medications to help prevent your body from rejecting the donor kidney. These medications can cause a variety of side effects, including:

  • Acne
  • Bone thinning (osteoporosis) and bone damage (osteonecrosis)
  • Diabetes
  • Excessive hair growth or hair loss
  • High blood pressure
  • High cholesterol
  • Increased risk of cancer, particularly skin cancer and lymphoma
  • Infection
  • Puffiness (edema)
  • Weight gain

How you prepare

Choosing a transplant center

If your doctor recommends a kidney transplant, you may be referred to a transplant center. You're also free to select a transplant center on your own or choose a center from your insurance company's list of preferred providers.

When you're considering transplant centers, you may want to:

  • Learn about the number and type of transplants the center performs each year
  • Ask about the transplant center's kidney transplant survival rates
  • Compare transplant center statistics through the database maintained by the Scientific Registry of Transplant Recipients
  • Find out if the center offers paired donation or donation chain programs that might increase your chances of receiving a living-donor kidney
  • Understand the costs that will be incurred before, during and after your transplant. Costs will include tests, organ procurement, surgery, hospital stays, and transportation to and from the center for the procedure and follow-up appointments
  • Consider additional services provided by the transplant center, such as coordinating support groups, assisting with travel arrangements, helping with local housing for your recovery period and offering referrals to other resources
  • Assess the center's commitment to keeping up with the latest transplant technology and techniques, which indicates that the program is growing

Evaluation

After you've selected a transplant center, you'll be evaluated to determine whether you meet the center's eligibility requirements for a kidney transplant.

The team at the transplant center will assess whether you:

  • Are healthy enough to have surgery and tolerate lifelong post-transplant medications
  • Have any medical conditions that would interfere with transplant success
  • Are willing and able to take medications as directed and follow the suggestions of the transplant team

The evaluation process may take several days and includes:

  • A thorough physical exam
  • Imaging scans, such as X-ray, MRI or CT scans
  • Blood tests
  • Psychological evaluation
  • Any other necessary testing as determined by your doctor

After your evaluation, your transplant team will discuss the results with you and tell you whether you've been accepted as a kidney transplant candidate. Each transplant center has its own eligibility criteria. If you aren't accepted at one transplant center, you may apply to others.

What you can expect

Before the procedure

Finding a match

A kidney donor can be living or deceased, related or unrelated to you. Your transplant team will consider several factors when evaluating whether a donor kidney will be a good match for you.

Tests to determine whether a donated kidney may be suitable for you include:

  • Blood typing. It's preferable to get a kidney from a donor whose blood type matches or is compatible to your own. Blood-type incompatible transplants are also possible but require additional medical treatment before and after transplant to reduce the risk of organ rejection. These are known as ABO incompatible kidney transplants.
  • Tissue typing. If your blood type is compatible, the next step is a tissue typing test called human leukocyte antigen (HLA) typing. This test compares genetic markers that increase the likelihood the transplanted kidney will last a long time. A good match means it's less likely that your body will reject the organ.
  • Crossmatch. The third and final matching test involves mixing a small sample of your blood with the donor's blood in the lab. The test determines whether antibodies in your blood will react against specific antigens in the donor's blood. A negative crossmatch means they are compatible and your body isn't as likely to reject the donor kidney. Positive crossmatch kidney transplants are also possible but require additional medical treatment before and after the transplant to reduce the risk of your antibodies reacting to the donor organ.

Additional factors your transplant team may consider in finding the most appropriate donor kidney for you include matching age, kidney size and infection exposure.

Living kidney donation

Finding a willing living kidney donor is an alternative to waiting for a compatible deceased-donor kidney to become available.

Family members are often the most likely to be compatible living kidney donors. But successful living-donor transplants are also common with kidneys donated from unrelated people, such as friends, co-workers or religious congregation members.

Paired donation is another type of living kidney donation if you have a willing kidney donor whose organ is not compatible with you or does not match well for other reasons. Rather than donating a kidney directly to you, your donor may give a kidney to someone who may be a better match. Then you receive a compatible kidney from that recipient's donor.

In some cases, more than two pairs of donors and recipients may be linked with a non-directed living kidney donor to form a donation chain with several recipients benefitting from the non-directed donor's gift.

If a compatible living donor isn't available, your name will be placed on a waiting list for a deceased-donor kidney. Because there are fewer available kidneys than there are people waiting for a transplant, the waiting list continues to grow. The waiting time for a deceased-donor kidney is usually a few years.

Staying healthy

Whether you're waiting for a donated kidney or your transplant surgery is already scheduled, work to stay healthy. Being healthy and as active as you're able can make it more likely you'll be ready for the transplant surgery when the time comes. It may also help speed your recovery from surgery. Work to:

  • Take your medications as prescribed
  • Follow your diet and exercise guidelines
  • Keep all appointments with your health care team
  • Stay involved in healthy activities, including relaxing and spending time with family and friends

Stay in touch with your transplant team and let them know of any significant changes in your health. If you're waiting for a donated kidney, make sure the transplant team knows how to reach you at all times. Keep your packed hospital bag handy, and make arrangements for transportation to the transplant center in advance.

During the procedure

Kidney transplants are performed with general anesthesia, so you're not aware during the procedure. The surgical team monitors your heart rate, blood pressure and blood oxygen level throughout the procedure.

During the surgery:

  • The surgeon makes an incision and places the new kidney in your lower abdomen. Unless your own kidneys are causing complications such as high blood pressure, kidney stones, pain or infection, they are left in place.
  • The blood vessels of the new kidney are attached to blood vessels in the lower part of your abdomen, just above one of your legs.
  • The new kidney's ureter — the tube that links the kidney to the bladder — is connected to your bladder.

After the procedure

After your kidney transplant, you can expect to:

  • Spend several days to a week in the hospital. Doctors and nurses monitor your condition in the hospital's transplant recovery area to watch for signs of complications. Your new kidney will make urine like your own kidneys did when they were healthy. Often this starts immediately. In other cases it may take several days. Expect soreness or pain around the incision site while you're healing. Most kidney transplant recipients can return to work and other normal activities within three to eight weeks after transplant. No lifting objects weighing more than 10 pounds or exercise other than walking until the wound has healed (usually about six weeks after surgery).
  • Have frequent checkups as you continue recovering. After you leave the hospital, close monitoring is necessary for a few weeks. You may need blood tests several times a week and have your medications adjusted in the weeks following your transplant. During this time, if you live in another town, you may need to make arrangements to stay near the transplant center.
  • Take medications the rest of your life. You'll take a number of medications after your kidney transplant. Drugs called immunosuppressants (anti-rejection medications) help keep your immune system from attacking and rejecting your new kidney. Additional drugs help reduce the risk of other complications, such as infection, after your transplant.

Results

After a successful kidney transplant, your new kidney will filter your blood, and you will no longer need dialysis.

To prevent your body from rejecting your donor kidney, you'll need medications to suppress your immune system. Because these anti-rejection medications make your body more vulnerable to infection, your doctor may also prescribe antibacterial, antiviral and antifungal medications.

After transplant, skin checkups with a dermatologist to screen for skin cancer and keeping your other cancer screening up to date is strongly advised.

Kidney transplant success rates

According to the Organ Procurement and Transplantation Network:

  • Failure of the transplanted kidney is reported in about 4 percent of deceased-donor kidney transplant recipients within one year after transplant and in 21 percent of cases five years after transplant.
  • Among living-donor kidney transplant recipients, failure rates are about 3 percent at one year and 14 percent at five years after transplant.

Survival rates among kidney transplant recipients in U.S. transplant centers can be found online at the Scientific Registry of Transplant Recipients.

If your new kidney fails, you can resume dialysis or consider a second transplant. You may also choose to discontinue treatment. This decision depends on your current health, your ability to withstand surgery and your expectations for maintaining a certain quality of life.

Coping and support

It's normal to feel anxious or overwhelmed while waiting for a transplant or to have fears about rejection, returning to work or other issues after a transplant. Seeking the support of friends and family members can help you cope during this stressful time.

Your Mayo Clinic transplant team can also assist you with other useful resources and coping strategies throughout the transplant process, such as:

  • Joining a support group for transplant recipients. Talking with others who have shared your experience can ease fears and anxiety.
  • Sharing your experiences on social media. Mayo Clinic has a Transplantation at Mayo Clinic Facebook page dedicated to helping transplant recipients and donors connect to each other online.
  • Finding rehabilitation services. If you're returning to work, your Mayo Clinic social worker may be able to connect you with rehabilitation services provided by your home state's Department of Vocational Rehabilitation.
  • Setting realistic goals and expectations. Recognize that life after transplant may not be exactly the same as life before transplant. Having realistic expectations about results and recovery time can help reduce stress.
  • Educating yourself. Learn as much as you can about your procedure and ask questions about things you don't understand. Knowledge is empowering.

New medication options

Mayo Clinic researchers actively study medications and treatments for people with kidney transplants, including new medications (immunosuppressive medications) to keep your body from rejecting your kidney transplant.

Researchers are also investigating better ways to lower antibody levels in your blood to reduce rejection of a donor kidney and improve outcomes when the match between a donor and recipient isn't ideal (ABO incompatible and positive crossmatch kidney transplant).

Other research areas include looking at new ways to use immunosuppressive medications, including tacrolimus (Prograf, Protopic), sirolimus (Rapamune), belatacept and steroid-free immunosuppression medication options, , to help reduce side effects and complications for people with kidney transplants.

Read more about the Kidney/Pancreas/Islet Transplant Research program.

Diet and nutrition

After your kidney transplant, you may need to adjust your diet to keep your new kidney healthy and functioning well. You'll have fewer dietary restrictions than if you were receiving dialysis therapy before your transplant, but you still may need to make some diet changes.

Your Mayo Clinic transplant team includes a nutrition specialist (dietitian) who can discuss your nutrition and diet needs and answer any questions you have after your transplant.

Some of your medications may increase your appetite and make it easier to gain weight. But reaching and maintaining a healthy weight through diet and exercise is just as important for transplant recipients as it is for everyone else to reduce the risk of heart disease, high blood pressure and diabetes.

You may need to keep track of how many calories you consume or limit foods high in sugar and fat.

Your Mayo Clinic dietitian will also provide you with several healthy food options and ideas to use in your nutrition plan. Your dietitian's recommendations after kidney transplant may include:

  • Eating at least five servings of fruits and vegetables each day
  • Avoiding grapefruit and grapefruit juice due to its effect on a group of immunosuppression medications (calcineurin inhibitors)
  • Having enough fiber in your daily diet
  • Drinking low-fat milk or eating other low-fat dairy products, which is important to maintain optimal calcium and phosphorus levels
  • Eating lean meats, poultry and fish
  • Maintaining a low-salt and low-fat diet
  • Following food safety guidelines
  • Staying hydrated by drinking adequate water and other fluids each day

Exercise

Exercise and physical activity should be a regular part of your life after a kidney transplant to continue improving your overall physical and mental health.

After a transplant, regular exercise helps boost energy levels and increase strength. It also helps you maintain a healthy weight, reduce stress and prevent common post-transplant complications such as high blood pressure and cholesterol levels.

Your Mayo Clinic transplant team will recommend a physical activity program based on your individual needs and goals.

Soon after your transplant, you should walk as much as you can. Then start incorporating more physical activity into your daily life, including participating in at least 30 minutes of moderate exercise five days a week.

Walking, bicycling, swimming, low-impact strength training and other physical activities you enjoy can all be a part of a healthy, active lifestyle after transplant. But be sure to check in with your transplant team before starting or changing your post-transplant exercise routine.