High blood protein (hyperproteinemia) is an increase in the concentration of protein in the bloodstream. High blood protein is not a specific disease or condition in itself, but it might indicate you have a disease.
High blood protein rarely causes signs or symptoms on its own. But sometimes it is uncovered while you're having blood tests done as part of an evaluation for some other problem or symptom.
If your doctor discovers high blood protein during an evaluation, he or she may recommend additional tests to determine if there is an underlying problem.
A total protein test can determine whether you have high blood protein. Other more-specific tests, including serum protein electrophoresis (SPEP), can help determine the exact source, such as liver or bone marrow, as well as the specific protein type involved in your high blood protein levels. Your doctor may order an SPEP if he or she suspects you have a bone marrow disease.
Oct. 04, 2017
- Total protein and Albumin/Globulin (A/G) ratio. American Association for Clinical Chemistry. https://labtestsonline.org/understanding/analytes/tp/tab/glance. Accessed Sept. 4, 2017.
- Amyloidosis and kidney disease. National Kidney and Urologic Diseases Information Clearinghouse. https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis. Accessed Sept. 4, 2017.
- Monoclonal gammopathies of undetermined significance (MGUS). Merck Manual Professional Version. http://www.merckmanuals.com/professional/hematology-and-oncology/plasma-cell-disorders/monoclonal-gammopathy-of-undetermined-significance-mgus. Accessed Sept. 4, 2017.
- Rajkumar SV. Recognition of monoclonal proteins. https://www.uptodate.com/contents/search. Accessed Sept. 4, 2017.
- Blood basics. American Society of Hematology. http://www.hematology.org/Patients/Basics/. Accessed Sept. 5, 2017.