Aging-related hormone changes in men are different from those in women. Understand the signs, symptoms and treatment options.By Mayo Clinic Staff
Hormone changes are a natural part of aging. Unlike the more dramatic reproductive hormone plunge that occurs in women during menopause, however, sex hormone changes in men occur gradually. Here's what you need to know.
The term "male menopause" has been used to describe decreasing testosterone levels related to aging. But aging-related hormone changes in women and men are different.
In women, ovulation ends and hormone production plummets during a relatively short period of time. This is known as menopause. In men, production of testosterone and other hormones declines over a period of many years and the consequences aren't necessarily clear. This gradual decline of testosterone levels is called late-onset hypogonadism or age-related low testosterone.
A man's testosterone levels decline on average about 1% a year after age 40. But most older men still have testosterone levels within the normal range, with only an estimated 10% to 25% having levels considered to be low.
Low testosterone levels in older men often go unnoticed. Testosterone levels can be checked by a blood test, but tests aren't routinely done. And many men who have low testosterone levels experience no symptoms. In addition, the signs and symptoms associated with low testosterone aren't specific to low testosterone. They can also be caused by a person's age, medication use or other conditions, such as having a body mass index of 30 or higher. Still, signs and symptoms suggestive of low testosterone include:
- Reduced sexual desire and activity
- Decreased spontaneous erections or erectile dysfunction
- Breast discomfort or swelling
- Height loss, low trauma fracture or low bone mineral density
- Hot flushes or sweats
Other possible symptoms include decreased energy, motivation and confidence, depressed mood, and poor concentration. It's also possible to experience increased sleepiness, sleep disturbances, mild unexplained anemia, reduced muscle bulk and strength, and increased body fat.
Experts recommend only testing older men for low testosterone if they have signs or symptoms. If an initial test shows low testosterone, the test should be repeated to confirm the results. If low testosterone is confirmed, further testing of the pituitary gland is recommended to determine the cause and rule out other hormone deficiencies. The pituitary gland is a kidney-bean-sized gland situated at the base of your brain. It is part of your body's endocrine system, which consists of all the glands that produce and regulate hormones.
Recommendations on testosterone therapy for men with age-related low testosterone vary. In 2020, the American College of Physicians recommended that doctors consider starting testosterone treatment in men with sexual dysfunction who want to improve their sexual function, after explaining the risks and benefits. In 2018, the Endocrine Society recommended testosterone therapy for men with age-related low testosterone who have signs and symptoms associated with low testosterone.
Some experts also recommend offering testosterone treatment to men with age-related low testosterone without the presence of signs or symptoms.
If you choose to start testosterone therapy, your doctor will explain the different ways testosterone can be administered, target levels and follow-up testing.
For some men, testosterone therapy relieves bothersome signs and symptoms of testosterone deficiency. For others, the benefits aren't clear and there are possible risks.
Though further research is needed, testosterone therapy might stimulate growth of metastatic prostate and breast cancer. Testosterone therapy may also increase the risk of heart attack and stroke and contribute to the formation of blood clots in the veins.
Your doctor will likely recommend against starting testosterone therapy if your fertility is important in the near future or if you have conditions such as breast or prostate cancer, untreated severe obstructive sleep apnea, uncontrolled heart failure or thrombophilia, or if you've recently had a heart attack or stroke.
If you think you might have low testosterone, talk to your doctor about your signs and symptoms, testing, and possible treatment options. Your doctor can help you weigh the pros and cons of treatment.
June 20, 2020
- Snyder PJ. Approach to older men with low testosterone. https://www.uptodate.com/contents/search. Accessed Feb. 6, 2020.
- Qaseem A, et al. Testosterone treatment in adult men with age-related low testosterone: A clinical guideline from the American College of Physicians. Annals of Internal Medicine. 2020; doi:10.7326/M19-0882.
- Melmed S, et al. Endocrinology and aging. In: Williams Textbook of Endocrinology. 14th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Feb. 6, 2020.
- Bhasin S, et al. Testosterone therapy in men with hypogonadism: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism. 2018; doi:10.1210/jc.2018-00229.
- Male menopause: Myth vs. fact. The Journal of Clinical Endocrinology and Metabolism. 2014; doi 10.1210/jc.2014-v99i10-49A.
- Diem SJ, et al. Efficacy and safety of testosterone treatment in men: An evidence report for a clinical practice guideline by the American College of Physicians. Annals of Internal Medicine. 2020; doi:10.7326/M19-0830.