Is breakthrough bleeding more common with extended-cycle birth control pills, such as Seasonale and others?
Answer From Shannon K. Laughlin-Tommaso, M.D.
Spotting or bleeding between periods (breakthrough bleeding) can occur with any birth control pill, especially during the first few months of use. However, breakthrough bleeding is more likely with continuous and extended-cycle regimens — such as generic Seasonale (Jolessa, Quasense), generic Seasonique (Amethia, Ashlyna, Camrese) and generic Quartette (Rivelsa) — than with the traditional 28-day schedule. Breakthrough bleeding can also occur when taking normal 28-day birth control pills in a continuous manner.
What causes breakthrough bleeding with oral contraceptives isn't always clear. It may simply take time for your body to adjust to the hormones in the pill or for your uterus to transition to a thinner lining (endometrium).
You're more likely to experience breakthrough bleeding if you:
- Miss a pill
- Start a new medication, such as certain antibiotics, or take supplements, such as St. John's wort, that may interfere with the contraceptive
- Become ill with vomiting or diarrhea, which may impair absorption of the medication
Unpredictable bleeding resulting from the use of continuous or extended-cycle birth control pills usually decreases with time. In the meantime:
- Continue taking the medication as directed. Breakthrough bleeding isn't a sign that the pill isn't working. If you stop taking it, you risk unplanned pregnancy.
- Track breakthrough bleeding in a calendar or diary. Typically, careful tracking offers reassurance that breakthrough bleeding is decreasing.
- Ask your doctor about taking a short pill-free break. If you've taken active pills for at least 21 days, your doctor may suggest that you stop for three days to allow bleeding that resembles a period and then take the pill again for at least 21 days.
- If you smoke, ask your doctor to help you quit. Women who smoke are more likely to experience breakthrough bleeding than are women who don't smoke.
If breakthrough bleeding becomes heavy or lasts more than seven days in a row, contact your doctor. He or she will consider other possible causes of breakthrough bleeding, such as an infection. Depending on the circumstances, your doctor may recommend an alternative method of contraception.
Shannon K. Laughlin-Tommaso, M.D.
March 20, 2018
- Edelman A, et al. Management of unscheduled bleeding in women using contraception. https://www.uptodate.com/contents/search. Accessed Jan. 11, 2017.
- Seasonale (prescribing information). North Wales, Pa.: Teva Women's Health; 2017. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&applno=021544. Accessed Jan. 12, 2018.
- Seasonique (prescribing information). North Wales, Pa.: Teva Women's Health; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=95e06935-8788-420c-b4a4-dc6ea339c7d0&audience=consumer. Accessed Jan. 12, 2018.
- Quartette (prescribing information). Sellersville, Pa.: Teva Women's Health; 2017. http://www.tevausa.com/SpecialtyMedicines.aspx. Accessed Jan. 12, 2018.
- Nappi RE, et al. Cycle control with an extended-regimen oral contraceptive combining levonorgestrel and ethinyl estradiol that includes continuous low-dose ethinyl estradiol instead of the traditional hormone-free interval. International Journal of Women’s Health. 2017;9:739.
- Nappi RE, et al. Extended regimen combined oral contraception: A review of evolving concepts and acceptance by women and clinicians. The European Journal of Contraception and Reproductive Health Care. 2016;21:106.