Selegiline (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

Less common

1. Blurred vision
2. bruising
3. chest pain or tightness
4. decreased urine
5. difficult or labored breathing
6. difficulty with swallowing
7. discouragement
8. dizziness
9. dry mouth
10. feeling sad or empty
11. headache
12. increased thirst
13. irregular heartbeat
14. irritability
15. large, flat, blue or purplish patches in the skin
16. loss of appetite
17. loss of interest or pleasure
18. mood changes
19. muscle pain or cramps
20. nausea or vomiting
21. nervousness
22. numbness or tingling in the hands, feet, or lips
23. pounding in the ears
24. seeing, hearing, or feeling things that are not there
25. seizures
26. shakiness and unsteady walk
27. shakiness in the legs, arms, hands, or feet
28. sleepiness or unusual drowsiness
29. slow or fast heartbeat
30. swelling or inflammation of the mouth
31. tiredness
32. trouble concentrating
33. trouble sleeping
34. unsteadiness, trembling, or other problems with muscle control or coordination
35. unusual tiredness or weakness

Incidence not known

1. Agitation
2. diarrhea
3. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
4. fever
5. overactive reflexes
6. poor coordination
7. restlessness
8. shivering
9. sweating
10. talking or acting with excitement you cannot control

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Agitation
2. chest pain
3. difficulty opening the mouth or lockjaw
4. dizziness (severe) or fainting
5. fast or irregular pulse (continuing)
6. high fever
7. high or low blood pressure
8. severe spasm where the head and heels are bent backward and the body arched forward
9. trouble breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Dry skin
2. hives, itching, or skin rash
3. itching, scaling, severe redness, soreness, or swelling of the skin
4. runny or stuffy nose
5. sneezing

Less common

1. Acid or sour stomach
2. back pain
3. belching
4. bloated or full feeling
5. body aches or pain
6. congestion
7. cough
8. difficulty having a bowel movement (stool)
9. difficulty with moving
10. dryness or soreness of the throat
11. excess air or gas in the stomach or intestines
12. heartburn
13. hoarseness
14. indigestion
15. joint pain
16. leg cramps
17. muscle aches, cramps, pains, or stiffness
18. passing gas
19. stomach discomfort, upset, or pain
20. swollen joints
21. tender, swollen glands in the neck
22. tooth problems
23. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: June 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.