Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of ponesimod in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ponesimod in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Bepridil
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Cisapride
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Dronedarone
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Levoketoconazole
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Mesoridazine
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Pimozide
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Piperaquine
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Saquinavir
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Sparfloxacin
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Terfenadine
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Thioridazine
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Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Acebutolol
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Acecainide
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Adagrasib
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Adenovirus Vaccine, Live
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Ajmaline
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Alemtuzumab
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Alfuzosin
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Amiodarone
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Amisulpride
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Amitriptyline
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Amlodipine
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Anagrelide
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Apomorphine
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Aranidipine
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Aripiprazole
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Aripiprazole Lauroxil
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Arsenic Trioxide
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Asenapine
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Astemizole
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Atazanavir
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Atenolol
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Azithromycin
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Bacillus of Calmette and Guerin Vaccine, Live
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Bedaquiline
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Betaxolol
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Bisoprolol
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Bretylium
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Buprenorphine
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Buserelin
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Carbamazepine
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Carteolol
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Carvedilol
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Celiprolol
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Ceritinib
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Chloroquine
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Chlorpromazine
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Cholera Vaccine, Live
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Cilnidipine
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Ciprofloxacin
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Citalopram
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Clarithromycin
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Clevidipine
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Clofazimine
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Clomipramine
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Clothiapine
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Clozapine
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Crizotinib
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Cyclobenzaprine
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Dabrafenib
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Dasatinib
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Degarelix
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Delamanid
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Dengue Tetravalent Vaccine, Live
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Desipramine
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Deslorelin
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Deutetrabenazine
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Dexmedetomidine
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Digoxin
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Diltiazem
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Disopyramide
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Dofetilide
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Dolasetron
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Domperidone
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Donepezil
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Doxepin
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Droperidol
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Ebastine
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Ebola Zaire Vaccine, Live
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Efavirenz
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Encorafenib
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Entrectinib
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Eribulin
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Erythromycin
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Escitalopram
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Esmolol
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Etrasimod
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Famotidine
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Felbamate
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Felodipine
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Fexinidazole
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Fingolimod
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Flecainide
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Fluconazole
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Fluoxetine
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Formoterol
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Foscarnet
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Fosphenytoin
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Galantamine
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Gatifloxacin
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Gemifloxacin
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Gepirone
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Givinostat
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Glasdegib
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Gonadorelin
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Goserelin
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Granisetron
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Halofantrine
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Haloperidol
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Histrelin
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Hydroquinidine
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Hydroxychloroquine
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Hydroxyzine
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Ibutilide
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Iloperidone
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Imipramine
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Influenza Virus Vaccine, Live
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Inotuzumab Ozogamicin
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Isradipine
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Itraconazole
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Ivabradine
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Ivosidenib
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Ketoconazole
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Labetalol
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Lapatinib
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Lefamulin
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Lenvatinib
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Lercanidipine
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Leuprolide
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Levobunolol
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Levofloxacin
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Lofexidine
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Lonafarnib
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Lumefantrine
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Macimorelin
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Manidipine
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Mavorixafor
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Measles Virus Vaccine, Live
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Mefloquine
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Methadone
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Methotrimeprazine
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Metipranolol
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Metoprolol
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Metronidazole
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Mifepristone
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Mizolastine
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Mobocertinib
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Moricizine
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Moxifloxacin
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Mumps Virus Vaccine, Live
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Nadolol
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Nafarelin
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Nebivolol
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Nelfinavir
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Nicardipine
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Nifedipine
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Nilotinib
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Nimodipine
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Nisoldipine
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Nitrendipine
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Norfloxacin
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Octreotide
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Ofloxacin
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Olanzapine
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Ondansetron
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Osilodrostat
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Osimertinib
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Oxaliplatin
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Oxprenolol
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Paliperidone
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Panobinostat
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Papaverine
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Paroxetine
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Pasireotide
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Pazopanib
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Penbutolol
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Pentamidine
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Perphenazine
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Phenobarbital
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Phenytoin
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Pimavanserin
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Pindolol
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Pipamperone
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Pitolisant
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Poliovirus Vaccine, Live
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Posaconazole
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Prajmaline
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Primidone
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Probucol
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Procainamide
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Prochlorperazine
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Promethazine
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Propafenone
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Propranolol
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Protriptyline
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Quetiapine
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Quinidine
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Quinine
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Quizartinib
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Ranolazine
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Relugolix
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Ribociclib
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Rifampin
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Rilpivirine
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Risperidone
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Ritonavir
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Rotavirus Vaccine, Live
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Rubella Virus Vaccine, Live
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Selpercatinib
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Sertindole
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Sertraline
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Sevoflurane
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Siponimod
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Smallpox Monkeypox Vaccine, Live Non-Replicating
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Smallpox Vaccine
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Sodium Phosphate
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Sodium Phosphate, Dibasic
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Sodium Phosphate, Monobasic
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Solifenacin
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Sorafenib
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Sotalol
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Sparteine
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Sulpiride
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Sultopride
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Sunitinib
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Tacrolimus
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Tamoxifen
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Tedisamil
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Telaprevir
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Telavancin
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Telithromycin
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Tetrabenazine
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Timolol
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Tolterodine
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Toremifene
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Trazodone
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Triclabendazole
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Trimipramine
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Triptorelin
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Typhoid Vaccine, Live
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Vandetanib
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Vardenafil
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Varicella Virus Vaccine, Live
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Vemurafenib
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Venlafaxine
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Verapamil
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Vernakalant
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Vilanterol
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Vinflunine
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Voclosporin
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Voriconazole
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Vorinostat
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Yellow Fever Vaccine
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Zoster Vaccine, Live
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Zotepine
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Zuclopenthixol
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Angina (chest pain), unstable (within the last 6 months) or
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Heart attack (within the last 6 months) or
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Heart failure (Class III or IV) (within the last 6 months) or
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Heart rhythm problems (eg, Mobitz type II second-degree, third-degree heart block, sick sinus syndrome), without a pacemaker or
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Stroke, including transient ischemic attack (within the last 6 months)—Should not be used in patients with these conditions.
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Asthma or
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Bradycardia (slow heartbeat), history of or
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Chronic obstructive pulmonary disease (COPD) or
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Fainting, recurrent, history of or
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Hypertension (high blood pressure) or
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Liver disease, or history of or
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Pulmonary fibrosis or
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Skin cancer, or history of—Use with caution. May make these conditions worse.
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Diabetes or
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Uveitis (eye swelling), history of or
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Weak immune system—Use with caution. May increase risk for more serious side effects.
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Infection—May decrease your body's ability to fight infections.
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Liver disease, moderate or severe—Use is not recommended in patients with this condition.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.