Naproxen (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Belching
2. bruising
3. chest tightness
4. difficult or labored breathing
5. feeling of indigestion
6. headache
7. itching skin
8. large, flat, blue, or purplish patches in the skin
9. pain in the chest below the breastbone
10. skin eruptions
11. stomach pain
12. swelling

Less common

1. Bloating
2. bloody or black, tarry stools
3. blurred or loss of vision
4. burning upper stomach pain
5. cloudy urine
6. constipation
7. decrease in urine output or decrease in urine-concentrating ability
8. disturbed color perception
9. double vision
10. fast, irregular, pounding, or racing heartbeat or pulse
11. halos around lights
12. indigestion
13. loss of appetite
14. nausea or vomiting
15. night blindness
16. overbright appearance of lights
17. pale skin
18. pinpoint red or purple spots on the skin
19. severe and continuing nausea
20. severe stomach burning, cramping, or pain
21. skin rash
22. swelling or inflammation of the mouth
23. trouble breathing
24. tunnel vision
25. unusual bleeding or bruising
26. unusual tiredness or weakness
27. vomiting of material that looks like coffee grounds
28. weight loss

Rare

1. Anxiety
2. back or leg pains
3. bleeding gums
4. blindness
5. blistering, peeling, or loosening of the skin
6. blood in the urine or stools
7. blue lips and fingernails
8. canker sores
9. change in the ability to see colors, especially blue or yellow
10. chest pain or discomfort
11. clay-colored stools
12. cold sweats
13. coma
14. confusion
15. cool, pale skin
16. cough or hoarseness
17. coughing that sometimes produces a pink frothy sputum
18. cracks in the skin
19. darkened urine
20. decreased vision
21. depression
22. diarrhea
23. difficult, burning, or painful urination
24. difficult, fast, or noisy breathing
25. difficulty with swallowing
26. dilated neck veins
27. dizziness
28. dry cough
29. dry mouth
30. early appearance of redness, or swelling of the skin
31. excess air or gas in the stomach
32. eye pain
33. fainting
34. fever with or without chills
35. fluid-filled skin blisters
36. flushed, dry skin
37. frequent urination
38. fruit-like breath odor
39. greatly decreased frequency of urination or amount of urine
40. hair loss
41. high fever
42. hives
43. increased hunger
44. increased sensitivity of the skin to sunlight
45. increased sweating
46. increased thirst
47. increased urination
48. increased volume of pale, dilute urine
49. irregular breathing
50. joint or muscle pain
51. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
52. late appearance of rash with or without weeping blisters that become crusted, especially in sun-exposed areas of skin, may extend to unexposed areas
53. light-colored stools
54. lightheadedness
55. loss of heat from the body
56. lower back or side pain
57. nervousness
58. nightmares
59. no blood pressure
60. no breathing
61. no pulse
62. nosebleeds
63. numbness or tingling in the hands, feet, or lips
64. pain in the ankles or knees
65. pain or burning in the throat
66. pain or discomfort in the arms, jaw, back, or neck
67. painful, red lumps under the skin, mostly on the legs
68. pains in the stomach, side, or abdomen, possibly radiating to the back
69. pale or blue lips, fingernails, or skin
70. pounding in the ears
71. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
72. rapid, shallow breathing
73. red, irritated eyes
74. red skin lesions, often with a purple center
75. red-green color blindness
76. redness or other discoloration of the skin
77. redness, swelling, or soreness of the tongue
78. scaly skin
79. seizures
80. severe sunburn
81. shakiness
82. skin thinness
83. slurred speech
84. sneezing
85. sore throat
86. sores, ulcers, or white spots on the lips or tongue or inside the mouth
87. sores, welting, or blisters
88. spots on your skin resembling a blister or pimple
89. stiff neck or back
90. stomach cramps or tenderness
91. stomach upset
92. swelling in the legs and ankles
93. swelling of the face, fingers, feet, or lower legs
94. swollen, painful, or tender lymph glands in the neck, armpit, or groin
95. tiny bumps on the inner lining of the eyelid
96. unexplained weight loss
97. unpleasant breath odor
98. watery or bloody diarrhea
99. weakness or heaviness of the legs
100. weight gain
101. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Bleeding under the skin
2. confusion about identity, place, and time
3. muscle tremors
4. restlessness
5. sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Continuing ringing or buzzing or other unexplained noise in the ears
2. hearing loss

Less common

1. Acid or sour stomach
2. change in hearing
3. feeling of constant movement of self or surroundings
4. passing gas
5. sensation of spinning
6. stomach soreness or discomfort

Rare

1. Appetite changes
2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
3. burning, dry, or itching eyes
4. difficulty with moving
5. discharge, excessive tearing
6. general feeling of discomfort or illness
7. lack or loss of strength
8. menstrual changes
9. muscle aching, cramping, stiffness, or weakness
10. not able to concentrate
11. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
12. seeing, hearing, or feeling things that are not there
13. shakiness in the legs, arms, hands, or feet
14. swollen joints
15. trembling or shaking of the hands or feet
16. trouble getting pregnant
17. trouble performing routine tasks
18. trouble sleeping
19. unusual drowsiness, dullness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: April 01, 2024

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