Methylprednisolone (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

1. Black, tarry stools
2. blindness
3. bloating
4. bloody vomit
5. blurred vision
6. bone pain
7. change in vision
8. chest pain
9. chills
10. confusion
11. constipation
12. cough
13. dark urine
14. darkening of the skin
15. decrease in height
16. decrease in the amount of urine
17. decreased range of motion
18. decreased vision
19. diarrhea
20. difficulty in swallowing
21. dilated neck veins
22. dizziness or lightheadedness
23. dry mouth
24. extreme tiredness or weakness
25. eye pain
26. eye tearing
27. eyeballs bulge out of the eye sockets
28. fainting
29. feeling of constant movement of self or surroundings
30. fever
31. flushed, dry skin
32. fruit-like breath odor
33. full or bloated feeling
34. headache
35. heartburn
36. hives, itching, skin rash
37. impaired wound healing
38. increased hunger
39. increased thirst
40. increased urination
41. indigestion
42. irregular breathing
43. irregular heartbeat
44. joint pain
45. limp
46. loss of appetite
47. loss of consciousness
48. lower back or side pain
49. mental depression
50. mood changes
51. muscle pain, cramps, or weakness
52. nausea
53. nervousness
54. noisy, rattling breathing
55. numbness or tingling in the hands, feet, or lips
56. pain in the back, ribs, arms, or legs
57. pain or burning in the throat
58. pain or swelling in the arms or legs without any injury
59. painful or difficult urination
60. painful, swollen joints
61. pains in the stomach, side, or abdomen, possibly radiating to the back
62. pounding in the ears
63. pressure in the stomach
64. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
65. seizures
66. sensation of spinning
67. severe or continuing stomach pain
68. slow growth in children
69. slow or fast heartbeat
70. sores, ulcers, or white spots on the lips or tongue or inside the mouth
71. swelling of the face, fingers, feet, abdominal or stomach area, or lower legs
72. tearing
73. tightness in the chest
74. troubled breathing
75. troubled breathing at rest
76. unexplained weight loss
77. unusual tiredness or weakness
78. vomiting
79. vomiting of material that looks like coffee grounds
80. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

1. Abnormal fat deposits on the face, neck, and trunk
2. acne
3. bruising
4. dry scalp
5. increased sweating
6. large, flat, blue or purplish patches in the skin
7. lightening of normal skin color
8. menstrual changes
9. reddish purple lines on the arms, face, legs, trunk, or groin
10. redness of the face
11. small, red or purple spots on the skin
12. swelling of the stomach area
13. thin, fragile skin
14. thinning of the scalp hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: Nov. 01, 2023