Hydrocodone (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

1. Bladder pain
2. bloating or swelling of the face, arms, hands, lower legs, or feet
3. bloody or cloudy urine
4. body aches or pain
5. chest tightness
6. chills
7. cough
8. depression
9. difficult or labored breathing
10. difficult, burning, or painful urination
11. ear congestion
12. fear or nervousness
13. fever
14. frequent urge to urinate
15. headache
16. loss of voice
17. lower back or side pain
18. rapid weight gain
19. runny or stuffy nose
20. sneezing
21. sore throat
22. tingling of the hands or feet
23. unusual tiredness or weakness
24. unusual weight gain or loss

Incidence not known

1. Agitation
2. darkening of the skin
3. diarrhea
4. difficulty swallowing
5. fast heartbeat
6. hives, itching, skin rash
7. increased sensitivity to pain
8. loss of appetite
9. mental depression
10. nausea
11. overactive reflexes
12. poor coordination
13. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
14. restlessness
15. shivering
16. talking or acting with excitement you cannot control
17. trembling or shaking
18. twitching
19. vomiting
20. worsening of pain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Blue lips and fingernails
2. blurred vision
3. change in consciousness
4. chest pain or discomfort
5. cold and clammy skin
6. confusion
7. constricted pupil (black part of the eye)
8. coughing that sometimes produces a pink frothy sputum
9. decreased awareness or responsiveness
10. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
11. increased sweating
12. irregular, fast or slow, or shallow breathing
13. lightheadedness, dizziness, or fainting
14. loss of consciousness
15. pale skin
16. sleepiness or unusual drowsiness
17. slow or irregular heartbeat
18. weak muscle tone

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Difficulty having a bowel movement

Less common

1. Back pain
2. dry mouth
3. heartburn
4. muscle spasms
5. stomach pain or discomfort

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: July 01, 2024

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