Proper Use

Drug information provided by: Merative, Micromedex®

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

This device is ready-to-use. Your doctor will tell you how many devices to use depending on your dose. You and your caregiver should be taught how to use this device in case a seizure cluster happens.

To use the nasal device:

  • Do not open the blister packs before use. Do not use the device if it looks damaged.
  • This medicine is for use only inside the nose. Do not get any of it into your eyes or on your skin. If it does get on these areas, rinse it off right away.
  • This device sprays one time only. Do not test or prime it before use.
  • Hold the device with your thumb on the bottom of the plunger and your first and middle fingers on either side of the nozzle.
  • Gently insert the tip of the nozzle into the nostril until your fingers are against the bottom of the patient's nose.
  • Press the bottom of the plunger firmly with your thumb to give a dose.
  • Remove the device from the nostril after each dose.
  • After giving this medicine, keep or move the patient onto their side, facing you, so you can watch them closely. Loosen any tight clothing and provide a safe area, away from furniture and other objects, where they can rest.
  • Take note of the time you first give the dose, as well as the second dose if needed.

If a second dose is needed, take it at least 4 hours after the first dose. Do not use more than 2 doses of diazepam to treat a single episode.

Do not use this medicine for more than 1 episode every 5 days or more than 5 episodes per month.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For nasal dosage form (solution):
    • For seizure clusters:
      • Adults and children 12 years of age and older—The dose is 0.2 milligram (mg) per kilogram (kg) body weight and must be determined by your doctor.
        • Weighing 76 kg and more—20 milligrams (mg) or two 10 mg devices per day. Spray once in each nostril.
        • Weighing 51 kg to 75 kg—15 mg or two 7.5 mg devices per day. Spray once in each nostril.
        • Weighing 28 kg to 50 kg—10 mg or one 10 mg device per day. Spray once in one nostril only.
        • Weighing 14 kg to 27 kg—5 mg or one 5 mg device per day. Spray once in one nostril only.
      • Children 6 to 11 years of age—The dose is 0.3 milligram (mg) per kilogram (kg) body weight and must be determined by your doctor.
        • Weighing 56 kg to 74 kg—20 mg or two 10 mg devices per day. Spray once in each nostril.
        • Weighing 38 kg to 55 kg—15 mg or two 7.5 mg devices per day. Spray once in each nostril.
        • Weighing 19 kg to 37 kg—10 mg or one 10 mg device per day. Spray once in one nostril only.
        • Weighing 10 kg to 18 kg—5 mg or one 5 mg device per day. Spray once in one nostril only.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.

Missed Dose

Call your doctor or pharmacist for instructions.

This medicine is used only during a seizure cluster episode.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Portions of this document last updated: June 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.