Ensayos clínicos A menudo, Mayo Clinic realiza estudios clínicos sobre diversos temas relacionados con la atención médica general y en varios estados, como en Minnesota, Florida y Arizona. A continuación, se enumeran los ensayos clínicos actuales.19 estudios en Medicina interna general (solo estudios abiertos). Filtra esta lista de estudios por sede, estatus, etc. Mayo Clinic Community Research Registry Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn. The primary goal of this study is to establish a database of underrepresented populations who consented to be contacted for biomedical research including clinical trials and bio-specimen research. The database will serve as sampling frames for selecting healthy individuals who initially meet specific study eligibility criteria. A Study to Evaluate Sex and Age Differences in Ehlers Danlos Syndrome Patients Jacksonville, Fla. The purpose of this study is to determine whether serum biomarkers and comorbidities differ between subjects with hEDS/HSD vs. other non-hypermobile EDS subtypes and whether sex and/or age differences exist, and to determine whether serum biomarkers and comorbidities differ between subjects with hEDS vs. HSD and whether sex and/or age differences exist. A Study to Evaluate Factors in Breast Cancer Screening Among Asian Americans in Olmsted and Surrounding Counties Rochester, Minn. The purpose of this study is to assess the effect of acculturation, socio-economic status (SES) and place of residence (urban vs. rural) on the level of participation in breast cancer screening programs and on the breast cancer knowledge and beliefs among Asian American women in Olmsted and surrounding counties. A Study to Evaluate the Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia Rochester, Minn. The purpose of this study is to understand why patients with indigestion, with or without diabetes, have gastrointestinal symptoms and, in particular, to understand where the symptoms are related to increased sensitivity to nutrients.Subsequently, look at the effects of Ondansetron on these patients' symptoms. A Study to Determine the Effect of Distance Reiki on Patient Reported Quality of Life (PRQoL) and Immunity Among Multiple Myeloma Patients Rochester, Minn. This study aims to demonstrate acceptability and feasibility of the use of Distance Reiki therapy versus sham Reiki therapy among multiple myeloma patients.It also aims to determine if there is a minimal clinically meaningful improvement in various QOL domains (Physical, Social, Emotional), overall QOL with use of Patient-Reported Outcomes Measurement Information System (PROMIS-29) and Single Item Linear Analogue Scale (LASA) after Distance Reik. Lastly, it aims to analyze the effect of Distance Reiki on expansion of the immune repertoire by comparing immune repertoires at baseline and at the end of the study by using Mass spectrometry by CyTOF® and multiplex polymerase chain reaction (PCR) sequencing of the T-cell receptors (TCRs) for assessment of immune repertoire diversity by iRepertoire®. Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women Rochester, Minn. The purpose of this study is test the effectiveness of the senolytic drug (Fisetin) in reducing senescent cell abundance in blood in elderly adults. A Study to Assess Markers of Aging Process Rochester, Minn. The purose of this study is to develop assays to identify markers related to aging processes in a variety of biospecimens, including but limited to blood, urine, saliva, buccal swabs, cerebrospinal fluid, tissue, etc. ***Not enrolling for cohort 2 at this time. A Study to Assess Reproductive History in Kidney Donors Rochester, Minn., Scottsdale/Phoenix, Ariz. The purpose of this study is to analyze the effect of parity, menopause and reproductive lifespan on kidney structure and function. T Cell Response to COVID19 Vaccinated Individuals Rochester, Minn., Jacksonville, Fla. The first aim of this study is to verify that the TCR beta sequencing and curation platforms we will be using are able to identify patients with severe COVID-19 based on the TCR repertoires. This may be accomplished by testing and analyzing results between two cohorts: patients presenting acutely to MCF with mild COVID-19 and patients presenting with severe COVID-19. This will be accomplished by utilizing the the immunoSEQ Human T-cell Receptor Beta (hsTCB) Assay (Adaptive Biothechnologies) and the publicly available ImmuneCODE Open Access Database to confirm previously published data (PMID: 34253751). Both procedures will be performed by the company that created both platforms, Adaptive Biothechnologies. The second aim of this study is to sequence the TCR receptors of participating patients and identify TCR motifs that may indicate a predisposition to (or protection from) severe SARS-CoV-2, leading to possible risk stratification of such patients, and whether or not age, gender or ethnicity has any contribution to said risk. This may require that we examine all three cohorts listed in the Subject Information section. The third aim is to measure SARS-CoV-2 anti-spike and anti-nucleocapsid antibodies to distinguish patients that have not been exposed to SARS-CoV-2 to those that have been exposed. Evaluation of the Effects of Caffeine, Via the ACE2 Receptor, on Clinical Severity of COVID-19 Disease Jacksonville, Fla. The purpose of this study is to assess levels of caffeine intake among patients who tested positive for COVID-19 infection and compare that to disease severity. Numeración de páginas Estudios clínicos Ir a página 11 Ir a página 22 SiguientePróxima página A continuación, se enumeran los ensayos clínicos actuales.19 estudios en Medicina interna general (solo estudios abiertos). Filtra esta lista de estudios por sede, estatus, etc. Mayo Clinic Community Research Registry Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn. The primary goal of this study is to establish a database of underrepresented populations who consented to be contacted for biomedical research including clinical trials and bio-specimen research. The database will serve as sampling frames for selecting healthy individuals who initially meet specific study eligibility criteria. A Study to Evaluate Sex and Age Differences in Ehlers Danlos Syndrome Patients Jacksonville, Fla. The purpose of this study is to determine whether serum biomarkers and comorbidities differ between subjects with hEDS/HSD vs. other non-hypermobile EDS subtypes and whether sex and/or age differences exist, and to determine whether serum biomarkers and comorbidities differ between subjects with hEDS vs. HSD and whether sex and/or age differences exist. A Study to Evaluate Factors in Breast Cancer Screening Among Asian Americans in Olmsted and Surrounding Counties Rochester, Minn. The purpose of this study is to assess the effect of acculturation, socio-economic status (SES) and place of residence (urban vs. rural) on the level of participation in breast cancer screening programs and on the breast cancer knowledge and beliefs among Asian American women in Olmsted and surrounding counties. A Study to Evaluate the Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia Rochester, Minn. The purpose of this study is to understand why patients with indigestion, with or without diabetes, have gastrointestinal symptoms and, in particular, to understand where the symptoms are related to increased sensitivity to nutrients.Subsequently, look at the effects of Ondansetron on these patients' symptoms. A Study to Determine the Effect of Distance Reiki on Patient Reported Quality of Life (PRQoL) and Immunity Among Multiple Myeloma Patients Rochester, Minn. This study aims to demonstrate acceptability and feasibility of the use of Distance Reiki therapy versus sham Reiki therapy among multiple myeloma patients.It also aims to determine if there is a minimal clinically meaningful improvement in various QOL domains (Physical, Social, Emotional), overall QOL with use of Patient-Reported Outcomes Measurement Information System (PROMIS-29) and Single Item Linear Analogue Scale (LASA) after Distance Reik. Lastly, it aims to analyze the effect of Distance Reiki on expansion of the immune repertoire by comparing immune repertoires at baseline and at the end of the study by using Mass spectrometry by CyTOF® and multiplex polymerase chain reaction (PCR) sequencing of the T-cell receptors (TCRs) for assessment of immune repertoire diversity by iRepertoire®. Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women Rochester, Minn. The purpose of this study is test the effectiveness of the senolytic drug (Fisetin) in reducing senescent cell abundance in blood in elderly adults. A Study to Assess Markers of Aging Process Rochester, Minn. The purose of this study is to develop assays to identify markers related to aging processes in a variety of biospecimens, including but limited to blood, urine, saliva, buccal swabs, cerebrospinal fluid, tissue, etc. ***Not enrolling for cohort 2 at this time. A Study to Assess Reproductive History in Kidney Donors Rochester, Minn., Scottsdale/Phoenix, Ariz. The purpose of this study is to analyze the effect of parity, menopause and reproductive lifespan on kidney structure and function. T Cell Response to COVID19 Vaccinated Individuals Rochester, Minn., Jacksonville, Fla. The first aim of this study is to verify that the TCR beta sequencing and curation platforms we will be using are able to identify patients with severe COVID-19 based on the TCR repertoires. This may be accomplished by testing and analyzing results between two cohorts: patients presenting acutely to MCF with mild COVID-19 and patients presenting with severe COVID-19. This will be accomplished by utilizing the the immunoSEQ Human T-cell Receptor Beta (hsTCB) Assay (Adaptive Biothechnologies) and the publicly available ImmuneCODE Open Access Database to confirm previously published data (PMID: 34253751). Both procedures will be performed by the company that created both platforms, Adaptive Biothechnologies. The second aim of this study is to sequence the TCR receptors of participating patients and identify TCR motifs that may indicate a predisposition to (or protection from) severe SARS-CoV-2, leading to possible risk stratification of such patients, and whether or not age, gender or ethnicity has any contribution to said risk. This may require that we examine all three cohorts listed in the Subject Information section. The third aim is to measure SARS-CoV-2 anti-spike and anti-nucleocapsid antibodies to distinguish patients that have not been exposed to SARS-CoV-2 to those that have been exposed. Evaluation of the Effects of Caffeine, Via the ACE2 Receptor, on Clinical Severity of COVID-19 Disease Jacksonville, Fla. The purpose of this study is to assess levels of caffeine intake among patients who tested positive for COVID-19 infection and compare that to disease severity. Numeración de páginas Estudios clínicos Ir a página 11 Ir a página 22 SiguientePróxima página Solicite una consulta Grupos especializadosInvestigación April 25, 2024 Comparte en: FacebookTwitter Medicina interna generalSeccionesPanorama generalMédicosGrupos especializadosEnsayos clínicosInvestigaciónExperiencia en Mayo Clinic e historias de pacientesCostos & seguro médicoNoticias de Mayo ClinicRemisiones Investigación: los pacientes son la prioridad Mostrar la transcripción Para video Investigación: los pacientes son la prioridad [SUENA MÚSICA] Dr. Joseph Sirven, profesor de Neurología, Mayo Clinic: La misión de Mayo se centra en el paciente. La prioridad es el paciente. Aquí, la misión y la investigación se hacen para progresar en la forma de ayudar mejor al paciente y para asegurarnos de que el paciente sea la prioridad en la atención médica. De muchas maneras, esto equivale a un ciclo. Puede comenzar con algo tan simple como una idea que se desarrolla en un laboratorio, se traslada a la atención directa del paciente y, si todo sale bien y resulta útil o beneficioso, pasa a ser el método estándar. Creo que una de las características tan singulares de la forma de investigar en Mayo es la concentración en el paciente, y es lo que realmente le ayuda a captar la atención de todos. SeccionesSolicite una ConsultaPanorama generalMédicosGrupos especializadosEnsayos clínicosInvestigaciónExperiencia en Mayo Clinic e historias de pacientesCostos & seguro médicoNoticias de Mayo ClinicRemisiones ORG-20461600 Centros y departamentos médicos Medicina interna general