Publicaciones Imprimir Elmadhoun O, Teixeira MT, Saddoughi SA, Fritz AV, Abutaka AG, Qamar Y, Nabzdyk CG, Combes A, Yalamuri SM, Ramakrishna H. The Contemporary Landscape of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation. J Cardiothorac Vasc Anesth. 2026 Jun; 40(6):1891-1896. Epub 2025 Dec 13. View PubMed Debertin JG, Ortiz BA, Wigle DA, Shen KR, Saddoughi SA, Puig CA, Cassivi SD, Reisenauer JS, Tapias LF. The Additive Effect of High-Risk Tumor Features on Long-Term Survival and Recurrence in Pathologic Stage I NSCLC. J Thorac Cardiovasc Surg. 2026 May 12. [Epub ahead of print] View PubMed Pennington KM, Heien H, Yadav H, El Mokahal A, Yao X, Peters SG, Escalante P, Saddoughi SA, Ngufor C, Razonable RR, Kennedy CC. Impact of Invasive Mold Infection-Coded Diagnoses on Utilization, Costs, and Mortality After Lung Transplantation. Chest. 2026 Apr 28. [Epub ahead of print] View PubMed Alwatari Y, Vierkant RA, Aizpuru MJ, Saddoughi SA, Puig CA, Reisenauer JS, Shen KR, Cassivi SD, Wigle DA, Tapias LF. Impact of Pulmonary Resection Extent on Nodal Upstaging in Clinical Stage IA1-2 NSCLC: Real-World Evidence of Low Detection Rates with Sublobar Resections. Clin Lung Cancer. 2026 Apr; 27(3):190-200.e1. Epub 2025 Nov 21. View PubMed Aizpuru M, Broida SE, Alwatari Y, Cassivi SD, Wigle DA, Saddoughi SA, Shen KR, Reisenauer JS, Houdek MT, Tapias LF. Primary Thoracic Synovial Sarcoma: Results of Treatment at a Single Institution. Ann Thorac Surg. 2026 Mar; 121(3):644-653. Epub 2025 Jul 08. View PubMed Powell C, Puig CA, Saddoughi SA, Tapias LF, Cassivi SD, Shen KR, Reisenauer JS, Wigle DA. Pulmonary mucormycosis: outcomes by treatment modality and underlying comorbidity. Ann Thorac Surg. 2026 Feb 25. [Epub ahead of print] View PubMed Ortiz BA, Engrav SK, Boland JM, Roden AC, Aubry MC, Abdallah FA, Yi ES, Cassivi SD, Wigle DA, Shen KR, Saddoughi SA, Reisenauer JS, Tapias LF. Diagnostic yield of routine frozen section pathology examination of lymph nodes in lung resections for clinical stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg. 2026 Feb; 171(2):493-499.e2. Epub 2025 Aug 29. View PubMed Saddoughi SA, Alwatari YA, Molina JR, Owen D. Emerging Strategies in the Management of Thymomas and Thymic Carcinomas. J Natl Compr Canc Netw. 2026 Feb; 24(2). View PubMed Aizpuru M, Boland JM, Lunn BW, Saddoughi SA, Shen KR, Cassivi SD, Wigle DA, Reisenauer JS, Tapias LF. FDG-PET/CT SUVmax Predicts Recurrence Risk of Resected Pleuropulmonary Solitary Fibrous Tumors. JTO Clin Res Rep. 2026 Feb; 7(2):100942. Epub 2025 Dec 13. View PubMed Ortiz BA, Engrav SK, Roden AC, Boland JM, Aubry MC, Abdallah FA, Yi ES, Saddoughi SA, Cassivi SD, Wigle DA, Shen KR, Reisenauer JS, Tapias LF. Impact of Frozen Section Pathology Examination of Surgical Margins in Sublobar Pulmonary Resections for Clinical Stage IA Non-small Cell Lung Cancer. Ann Thorac Surg. 2025 Dec; 120(6):1044-1051. Epub 2025 Apr 25. View PubMed Hendriksen BS, Ortiz BA, Wigle DA, Cassivi SD, Saddoughi SA, Puig CA, Shen KR, Reisenauer JS, Tapias LF. Risk factors and survival associated with lung cancer recurrence after curative-intent surgery: beyond TNM pathological staging. J Thorac Dis. 2025 Nov 30; 17(11):10285-10297. Epub 2025 Nov 26. View PubMed Mugu V, Sorin V, Chan A, Briggs C, Carr B, Olson M, Schupbach J, Zietlow J, Saddoughi S, Schmitz J, Khandelwal A. Feasibility of extracting key elements from thoracic surgical operative notes using foundational large language models. Journal of Thoracic Disease. 2025. Huang ES, Liu E, Kennedy CC, Saddoughi SA, Peters SG, Yadav H, Pennington KM. Psychosocial and Socioeconomic Factors Are Not Associated With Long-Term Survival After Lung Transplantation. Clin Transplant. 2025 Nov; 39(11):e70360. View PubMed Kayalar N, Saddoughi SA. Precision Medicine in Lung Transplantation. Thorac Surg Clin. 2025 Nov; 35(4):439-447. View PubMed Han Y, Shah A, Ho TP, Yao Y, Jebastin Thangaiah J, Siontis BL, Robinson SI, Okuno SH, Lee KN, Haddock MG, Villavicencio Theoduloz MA, Saddoughi S, Laack NN, Mutter RW, Xu-Welliver M. Understanding Cardiac Sarcoma: Prognostic Impact of Clinicopathologic Features and Treatment in a Modern National Cohort ESMO Rare Cancers. 2025. Aizpuru M, Elder BD, Spencer PJ, Saddoughi SA, Cajigas HR, Villavicencio MA. Management of cerebral ventriculoatrial shunt during pulmonary endarterectomy JTCVS Techniques. 2025. Ribeiro RVP, Altarabsheh SE, Segamanasinghe DL, Lopez-Muralles IW, Garcia Moreno AS, Knop G, Al-Azzam F, Mallea J, Brownfield DG, Olson AC, Gibbard DF, Jing Y, Cheng K, Saddoughi SA. Preconditioning donor lungs with lung-derived exosomes mitigates ischemia-reperfusion injury in a warm ischemia porcine DCD model. J Heart Lung Transplant. 2025 Jul; 44(7):1149-1160. Epub 2025 Mar 22. View PubMed Anyetei-Anum GP, White B, Yadav H, Kennedy CC, Peters SG, Scott JP, Villavicencio M, Spencer PJ, Saddoughi S, Pennington KM. Effect of native lung disease on post-transplant best lung function. Respir Med. 2025 Jul; 243:108128 Epub 2025 May 03 View PubMed Lei I, Sicim H, Gao W, Huang W, Noly PE, Pergande MR, Wilson MC, Lee A, Liu L, Abou El Ela A, Jiang M, Saddoughi SA, Pober JS, Platt JL, Cascalho M, Pagani FD, Chen YE, Pitt B, Wang Z, Mortensen RM, Ge Y, Tang PC. Mineralocorticoid receptor phase separation modulates cardiac preservation. Nat Cardiovasc Res. 2025 Jun; 4(6):710-726. Epub 2025 May 19. View PubMed Chauhan A, Ranganath N, Scott JP, Vergidis P, Roden AC, Spencer PJ, Villavicencio MA, Daly RC, Saddoughi SA. Redo bilateral lung transplantation in a previous heart-lung transplant recipient for invasive pulmonary scedosporiosis. JHLT Open. 2025 May; 8:100247. Epub 2025 Apr 01. View PubMed Kolaitis NA, Barnes H, Levine DJ, Castillo H, Arcasoy SM, Bacchetta M, Benvenuto L, Berman-Rosenzweig E, Cevasco M, Demarest CT, Dewachter C, Erasmus ME, Glanville AR, Granton J, Keshavjee S, Khangoora V, Krishnan S, Mercier O, Miltiades AN, Montani D, Murphy E, Robbins I, Rahaghi FF, Saddoughi SA, Savale L, Simon MA, Vachiery JL, Ventetuolo CE, Whitford HM, Girgis RE. Approach to Lung Transplantation in Pulmonary Arterial Hypertension: A Delphi Consensus on Behalf of the Transplant Task Force of the Pulmonary Vascular Research Institute. Pulm Circ. 2025 Apr; 15(2):e70088. Epub 2025 Apr 23. View PubMed Roden AC, Walkoff LA, Saddoughi SA. Type A Thymoma. Mayo Clin Proc. 2025 Mar; 100(3):499-500. View PubMed Tompkins AK, Cooke DT, Backhus L, DiMaio JM, Pereira SJ, Antonoff M, Merrill W, Erkmen CP, Society of Thoracic Surgeons Workforces on Diversity, Equity and Inclusion, Cardiothoracic Surgery Practice Models and Career Development. Intersection of Race and Gender in the Cardiothoracic Workforce: Study of Representation and Salary. Ann Thorac Surg. 2025 Mar; 119 (3):687-696 Epub 2024 Nov 08 View PubMed Choi K, Altarabsheh SE, Saddoughi SA, Spencer PJ, Lahr B, Ergi DG, Schumer E, Villavicencio MA. Impact of Time of Day on Surgical Outcomes After Lung Transplantation (Nighttime Lung Transplant). Ann Thorac Surg. 2025 Feb; 119(2):423-431. Epub 2024 Aug 30. View PubMed Aizpuru M, Briggs CM, Jimenez RE, Koo CW, Foster TR, Saddoughi SA. Tophaceous Gout Presenting as a Fluorodeoxyglucose-Avid Anterior Mediastinal Mass. Ann Thorac Surg. 2025 Feb; 119(2):472-475. Epub 2024 Oct 02. View PubMed Santore LA, Habermann E, Li Y, Villavicencio M, Spencer P, Pennington K, Rabi A, Cypel M, Saddoughi S. Variation in patient selection and outcomes of ecmo bridge to lung transplant across high and low volume centers: an analysis of the elso database. ASAIO Journal. 2025; 71 (Supplement 4):33-4 Rocco R, Hendriksen BS, Ortiz BA, Shen KR, Cassivi SD, Saddoughi S, Reisenauer JS, Wigle DA, Tapias LF. Impact of lymph node evaluation standard in patients undergoing lung resection for clinical stage IA pulmonary adenocarcinoma and squamous cell carcinoma. J Thorac Dis. 2024 Nov 30; 16(11):7663-7674. Epub 2024 Nov 11. View PubMed Shariff M, Kumar A, Stulak J, Naumann KE, Blackmon SH, Saddoughi SA. Gender gap in cardiothoracic surgery randomized controlled trial and post-hoc analysis of randomized controlled trial authorship from 2014 to 2020. Eur J Cardiothorac Surg. 2024 Oct 1; 66 (4) View PubMed Enofe N, Tompkins A, Cooke DT, Freeman K, DiMaio JM, Merrill W, Erkmen CP, Society of Thoracic Surgeons Workforces on Diversity, Equity, and Inclusion, Cardiothoracic Surgery Practice Models, and Career Development. A Report of Salaries of Academic Cardiothoracic Surgeons Based on Race and Ethnicity. Ann Thorac Surg. 2024 Sep; 118 (3):569-578 Epub 2024 May 08 View PubMed Treffalls JA, Bilgili A, Brennan Z, Sharaf OM, Griffeth EM, Chen Q, Pennington K, Spencer PJ, Villavicencio MA, Daly RC, Saddoughi SA. Procurement Trends, Indications, and Outcomes of Heart-Lung Transplantation in the Contemporary Era. Clin Transplant. 2024 Sep; 38 (9):e15447 View PubMed Sawal N, Pennington KM, Petrossian R, Reisenauer J, Mullon J, Midthun D, Nelson D, Anderson D, Edell E, Saddoughi SA, Spencer PJ, Villavicencio MA, Kennedy CC, Scott JP, Peters SG, Wylam ME, Kern RM. Custom silicone Y-stents for the management of anastomotic stenosis in lung transplant recipients. Respir Med. 2024 Sep; 231:107737 Epub 2024 July 08 View PubMed Garcia SI, Seelhammer TG, Saddoughi SA, Finch AS, Park JG, Wieruszewski PM. Cumulative epinephrine dose during cardiac arrest and neurologic outcome after extracorporeal cardiopulmonary resuscitation. Am J Emerg Med. 2024 Jun; 80:61-66. Epub 2024 Mar 15. View PubMed Pennington KM, Martin MJ, Murad MH, Sanborn D, Saddoughi SA, Gerberi D, Peters SG, Razonable RR, Kennedy CC. Risk Factors for Early Fungal Disease in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis. Transplantation. 2024 Apr 1; 108 (4):970-984 Epub 2023 Nov 13 View PubMed Saddoughi SA, Powell C, Stroh GR, Rajagopalan S, Bartholmai BJ, Boland JM, Aubry MC, Harmsen WS, Blackmon SH, Cassivi SD, Nichols FC, Reisenauer JS, Shen KR, Mansfield AS, Maldonado F, Peikert T, Wigle DA. Long-Term Survival and CANARY-Based Artificial Intelligence for Multifocal Lung Adenocarcinoma. Mayo Clin Proc Digit Health. 2024 Mar; 2 (1):44-52 Epub 2024 Jan 11 View PubMed Spencer PJ, Saddoughi SA, Choi K, Dickinson TA, Richman A, Reynolds FA, Villavicencio MA. Heart-Lung Transplantation From Donation After Circulatory Death Using Mobile Normothermic Regional Perfusion. ASAIO J. 2024 Jan 1; 70 (1):e13-e15 Epub 2023 Dec 23 View PubMed Choi K, Spadaccio C, Ribeiro RVP, Langlais BT, Villavicencio MA, Pennington K, Spencer PJ, Daly RC, Mallea J, Keshavjee S, Cypel M, Saddoughi SA. Early national trends of lung allograft use during donation after circulatory death heart procurement in the United States. JTCVS Open. 2023 Dec; 16:1020-1028. Epub 2023 Sep 04. View PubMed Abou Chaar MK, Godin A, Harmsen WS, Wzientek C, Saddoughi SA, Hallemeier CL, Cassivi SD, Nichols FC, Reisenauer JS, Shen KR, Tapias LF, Wigle DA, Blackmon SH. Determinants of Long-term Survival Decades After Esophagectomy for Esophageal Cancer. Ann Thorac Surg. 2023 Nov; 116 (5):1036-1044 Epub 2023 June 22 View PubMed Wahab A, Hanson AC, Peters S, Villavicencio MA, Saddoughi SA, Shah SZ, Spencer PJ, Kennedy CC, Pennington KM. Expanded extracorporeal membrane oxygenation bridge to heart and lung transplant candidate selection does not impact outcomes compared to traditional candidate selection criteria. J Thorac Dis. 2023 Jun 30; 15(6):3421-3430. Epub 2023 May 24. View PubMed Choi K, Spadaccio C, Altarabsheh SE, Knop G, Spencer PJ, Saddoughi SA, Tabar KR, Hassler KR, Villavicencio MA. Bilateral lung transplantation from a left ventricular assist device supported donor. JTCVS Tech. 2023 Jun; 19:164-165. Epub 2023 Apr 20. View PubMed Saddoughi SA, Cypel M. Expanding the Lung Donor Pool: Donation After Circulatory Death, Ex-Vivo Lung Perfusion and Hepatitis C Donors. Clin Chest Med. 2023 Mar; 44 (1):77-83 View PubMed Powell CL, Saddoughi SA, Wigle DA. Progress in genome-inspired treatment decisions for multifocal lung adenocarcinoma. Expert Rev Respir Med. 2023 Jul-Dec; 17(11):1009-1021. Epub 2023 Dec 26. View PubMed Saddoughi SA, Garijo JM, Yeung JC. Reply: There is no substitution for a surgeon's eyes, but sometimes she might need glasses. JTCVS Tech. 2022 Oct; 15:210-211 Epub 2021 Aug 14 View PubMed Schumer EM, Saddoughi SA, Spencer PJ, Pochettino A, Daly RC, Villavicencio MA. Lung transplantation long-term survival is worse in patients who have undergone previous cardiac surgery. Eur J Cardiothorac Surg. 2022 Sep 2; 62 (4) View PubMed Krishnan P, Saddoughi SS. Procurement of lungs from brain-dead donors. Indian J Thorac Cardiovasc Surg. 2021 Sep; 37 (Suppl 3):416-424 Epub 2021 Mar 19 View PubMed Saddoughi S, Taswell J, Spears G, Harmsen W, Allen M, Blackmon S, Cassivi S, Nichols F, Wigle D, Shen K. Patients younger than 45 years of age have superior 5-year survival in advanced esophageal cancer Shanghai Chest. 2019. Saddoughi SA, Abdelsattar ZM, Blackmon SH. National Trends in the Epidemiology of Malignant Pleural Mesothelioma: A National Cancer Data Base Study. Ann Thorac Surg. 2018 Feb; 105 (2):432-437 Epub 2017 Dec 07 View PubMed Saddoughi SA, Abel MD, Maleszewski JJ, Schaff HV. Acute aortitis of the ascending aorta. Interact Cardiovasc Thorac Surg. 2017 Jul 1; 25 (1):142-144 View PubMed Saddoughi SA, Reinersman JM, Zhukov YO, Taswell J, Mara K, Harmsen SW, Blackmon SH, Cassivi SD, Nichols F 3rd, Shen KR, Wigle DA, Allen MS. Survival After Surgical Resection of Stage IV Esophageal Cancer. Ann Thorac Surg. 2017 Jan; 103 (1):261-266 Epub 2016 Sept 09 View PubMed Saddoughi SA, Maleszewski JJ, Schaff HV. Cardiac myxoma: Simplifying a "complex" case. J Thorac Cardiovasc Surg. 2016 Nov; 152 (5):1439-1440 Epub 2016 Aug 04 View PubMed Saddoughi SA, Taswell J, Harmsen WS, Inra ML, Blackmon SH, Nichols FC 3rd, Cassivi SD, Wigle DA, Shen KR, Allen MS. Surgical Resection of Rare Esophageal Cancers. Ann Thorac Surg. 2016 Jan; 101: (1)311-5. View PubMed Saddoughi SA, Steinberg DH, Ikonomidis JS. Functioning Cooley-Cutter aortic valve prosthesis 40 years after implantation. J Thorac Cardiovasc Surg. 2014 Mar; 147 (3):e21-2 Epub 2013 Nov 27 View PubMed Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013 Oct; 123 (10):4144-57 Epub 2013 Sept 03 View PubMed Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, Quintas-Cardama A, Goldman JM, Apperley J, Reid A, Milojkovic D, Ziolo MT, Marcucci G, Ogretmen B, Neviani P, Perrotti D. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 2013 Sep 12; 122 (11):1923-34 Epub 2013 Aug 07 View PubMed Saddoughi SA, Ogretmen B. Diverse functions of ceramide in cancer cell death and proliferation. Adv Cancer Res. 2013; 117:37-58 View PubMed Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 2013 Jan; 5 (1):105-21 Epub 2012 Nov 25 View PubMed Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11 (5):1092-102 Epub 2012 Mar 27 View PubMed Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. J Biol Chem. 2011 Dec 9; 286 (49):42446-58 Epub 2011 Oct 19 View PubMed Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C(1)(8)-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15; 17 (18):6097-105 Epub 2011 July 26 View PubMed Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 2011 Jun 2; 117 (22):5941-52 Epub 2011 Apr 28 View PubMed Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol. 2010 Oct; 6 (10):1603-24 View PubMed Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23 (3):751-63 Epub 2008 Nov 21 View PubMed Saddoughi SA, Song P, Ogretmen B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem. 2008; 49:413-40 View PubMed Buzzeo MC, Iqbal AH, Long CM, Millar D, Patel S, Pellow MA, Saddoughi SA, Smenton AL, Turner JF, Wadhawan JD, Compton RG, Golen JA, Rheingold AL, Doerrer LH. Homoleptic cobalt and copper phenolate A2[M(OAr)4] compounds: the effect of phenoxide fluorination. Inorg Chem. 2004 Nov 29; 43 (24):7709-25 View PubMed PST-20533718 Inicio Publicaciones