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Craig M. Horbinski, M.D., Ph.D.

  1. Pathologist
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Publicaciones

  1. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW, Horbinski CM, Chandler JP, Ehret F, Gui C, Wang JZ, Park K, Ajmera S, Rosenblum M, Suwala AK, Kresbach C, Mount CW, Schuller U, Santagata S, Sahm F, Bale TA, Jackson C, Richardson TE, Cai C, Nassiri F, Zadeh G, Kaul D, Capper D, Magill ST, Golfinos JG, Sen C, Patel AJ, Raleigh DR, Moliterno J, Pacione D, Snuderl M, Bi WL. The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis. Lancet Oncol. 2025 Sep; 26 (9):1178-1190
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  2. Gui C, Wang JZ, Patil V, Landry AP, Singh O, Castelo-Branco P, Tabori U, Aldape K, Behling F, Barnholtz-Sloan JS, Horbinski C, Tabatabai G, Ajisebutu A, Liu J, Patel Z, Yakubov R, Kaloti R, Ellenbogen Y, Wilson C, Cohen-Gadol A, Tatagiba M, Holland EC, Sloan AE, Chotai S, Chambless LB, Gao A, Makarenko S, Yip S, Nassiri F, Zadeh G, International Consortium on Meningiomas (ICOM). Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study. Lancet Oncol. 2025 Sep; 26 (9):1191-1203
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  3. Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C, Verhaak RGW, Huang RY, Ahluwalia MS, Albert NL, Tonn JC, Schiff D, Barnholtz-Sloan JS, Ostrom Q, Aldape KD, Batchelor TT, Bindra RS, Chiocca EA, Cloughesy TF, DeGroot JF, French P, Galanis E, Galldiks N, Gilbert MR, Hegi ME, Lassman AB, Le Rhun E, Mehta MP, Mellinghoff IK, Minniti G, Roth P, Sanson M, Taphoorn MJB, von Deimling A, Weiss T, Wick W, Zadeh G, Reardon DA, Chang SM, Short SC, van den Bent MJ, Preusser M. Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions. Neuro Oncol. 2025 Aug 13 [Epub ahead of print]
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  4. Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P. Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression. JCI Insight. 2025 Jul 8; 10 (13) Epub 2025 July 08
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  5. Landry AP, Wang JZ, Liu J, Patil V, Gui C, Patel Z, Ajisebutu A, Ellenbogen Y, Wei Q, Singh O, Sosa J, Mansouri S, Wilson C, Cohen-Gadol AA, Zaazoue MA, Tabatabai G, Tatagiba M, Behling F, Barnholtz-Sloan JS, Sloan AE, Chotai S, Chambless LB, Rebchuk AD, Makarenko S, Yip S, Mansouri A, Tsang DS, Aldape K, Gao A, International Consortium on Meningiomas (ICOM), Nassiri F, Zadeh G. Development and validation of a molecular classifier of meningiomas. Neuro Oncol. 2025 Jun 21; 27(5):1258-1269.
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  6. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW. The excitatory milieu in glioma: mechanisms and therapeutic avenues. Neuro Oncol. 2025 Apr 18 [Epub ahead of print]
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  7. Seblani M, Zannikou M, Duffy JT, Joshi T, Levine RN, Thakur A, Puigdelloses-Vallcorba M, Horbinski CM, Miska J, Hambardzumyan D, Becher OJ, Balyasnikova IV. IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas. Acta Neuropathol Commun. 2025 Apr 2; 13 (1):69 Epub 2025 Apr 02
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  8. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY. Targeting PDGFRA-SHP2 Signaling Enhances Radiotherapy in IDH1-Mutant Glioma. Neuro Oncol. 2025 Mar 25 [Epub ahead of print]
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  9. McCord M, Sears T, Wang W, Chaliparambil R, An S, Sarkaria J, James CD, Ruggeri B, Gueble S, Bindra R, Horbinski C. The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma. Neuro Oncol. 2025 Mar 07; 27(3):644-651.
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  10. Nabors LB, Hattangadi-Gluth J, Horbinski C, Portnow J. NCCN CNS Tumor Guidelines Update for 2024. Neuro Oncol. 2025 Mar 7; 27 (3):595-596
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  11. Horbinski C, Solomon DA, Lukas RV, Packer RJ, Brastianos P, Wen PY, Snuderl M, Berger MS, Chang S, Fouladi M, Phillips JJ, Nabors B, Brat DJ, Huse JT, Aldape K, Sarkaria JN, Holdhoff M, Burns TC, Peters KB, Mellinghoff IK, Arons D, Galanis E. Molecular Testing for the World Health Organization Classification of Central Nervous System Tumors: A Review. JAMA Oncol. 2025 Mar 1; 11 (3):317-328
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  12. Sears TK, Wang W, Drumm M, Unruh D, McCord M, Horbinski C. F3 Expression Drives Sensitivity to the Antibody-Drug Conjugate Tisotumab Vedotin in Glioblastoma. Cancers (Basel). 2025 Feb 27; 17 (5)
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  13. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P, Castellani R, Vassar R, Miska J, Hu B, Cheng SY. Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma. iScience. 2025 Feb 21; 28 (2):111769 Epub 2025 Jan 07
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  14. Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC, Raleigh DR. A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence. Neuro Oncol. 2025 Feb 10; 27 (2):445-454
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  15. Chernet S, Kim H, Bhatia A, Horbinski C, Dixit K. Treatment of Isocitrate Dehydrogenase-Mutant Gliomas. Advances in Oncology. 2025; 5(1):135-150.
  16. Sullivan JJ, Chandler JP, Lesniak MS, Tate MC, Sonabend AM, Kalapurakal JA, Horbinski CM, Lukas RV, Kumthekar PU, Sachdev S. Clinical outcomes for pleomorphic xanthoastrocytoma patients. Neurooncol Pract. 2025 Feb; 12 (1):45-50 Epub 2024 Aug 10
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  17. Khalili BF, Walbert T, Horbinski C, Dixit K, Gururangan K, Thio H, Tate MC, Stupp R, Lukas RV, Templer JW. Levetiracetam and valproic acid in glioma: antiseizure and potential antineoplastic effects. Future Oncol. 2025 Feb; 21 (4):483-491 Epub 2025 Jan 09
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  18. Sloan AR, Gordillo AJ, Kennemer A, Khorana AA, Horbinski C, Kaelber DC, Cameron SJ, Lathia JD. Venous thromboembolism incidence shortens survival in isocitrate dehydrogenase wild-type glioblastoma. Neurooncol Adv. 2025 Jan-Dec; 7 (1):vdaf018 Epub 2025 Jan 31
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  19. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K, Zhong W, Santana-Santos L, Horbinski C, Castellani RJ, Sukhanova M, Jamshidi P. Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history. J Neuropathol Exp Neurol. 2025 Jan 1; 84 (1):84-86
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  20. Leclair NK, Choudury A, Chen WC, Magill ST, McCortney K, Horbinski CM, Chen Z, Goldschmidt E, Eaton CD, Bulsara KR, Bi WL, Patel AJ, Sahm F, Raleigh D, Anczukow O. RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups. Neuro Oncol. 2024 Dec 5; 26 (12):2222-2236
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  21. Thirunavu V, Drumm M, McCord M, Steffens A, Youngblood MW, Nandoliya KR, Smith H, Walshon J, McCortney K, Magill ST, Horbinski C. Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis. J Neurosurg. 2024 Dec 1; 141 (6):1644-1654 Epub 2024 July 05
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  22. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R, Brat D, Horbinski C. Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma. J Neuropathol Exp Neurol. 2024 Dec 1; 83 (12):1081-1083
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  23. Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L, Zhang DY, Castro B, Billingham L, Levey D, Huber O, Marques M, Savitsky DA, Morin BM, Muzzio M, Canney M, Horbinski C, Zhang P, Miska J, Padney S, Zhang B, Rabadan R, Phillips JJ, Butowski N, Heimberger AB, Hu J, Stupp R, Chand D, Lee-Chang C, Sonabend AM. Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas. Neuro Oncol. 2024 Nov 4; 26 (11):2044-2060
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  24. Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J, Saarela O, Pugh SL, Won M, Patel Z, Yakubov R, Kaloti R, Wilson C, Cohen-Gadol A, Zaazoue MA, Tabatabai G, Tatagiba M, Behling F, Almiron Bonnin DA, Holland EC, Kruser TJ, Barnholtz-Sloan JS, Sloan AE, Horbinski C, Chotai S, Chambless LB, Gao A, Rebchuk AD, Makarenko S, Yip S, Sahm F, Maas SLN, Tsang DS, International Consortium on Meningiomas (ICOM), Rogers CL, Aldape K, Nassiri F, Zadeh G. Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. Nat Med. 2024 Nov; 30(11):3173-3183. Epub 2024 Aug 21.
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  25. Nandoliya KR, Congivaram H, Youngblood MW, Chen WC, Chaliparambil RK, Horbinski CM, Choudhury A, Brat DJ, Chandler JP, Magill ST, Wolinsky JP. Clinical and methylomic features of spinal meningiomas. J Neurooncol. 2024 Nov; 170 (2):277-287 Epub 2024 Sept 10
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  26. Schubert MC, Soyka SJ, Tamimi A, Maus E, Schroers J, Wissmann N, Reyhan E, Tetzlaff SK, Yang Y, Denninger R, Peretzke R, Beretta C, Drumm M, Heuer A, Buchert V, Steffens A, Walshon J, McCortney K, Heiland S, Bendszus M, Neher P, Golebiewska A, Wick W, Winkler F, Breckwoldt MO, Kreshuk A, Kuner T, Horbinski C, Kurz FT, Prevedel R, Venkataramani V. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis. Nat Commun. 2024 Sep 10; 15 (1):7383 Epub 2024 Sept 10
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  27. Wang S, Castro BA, Katz JL, Arrieta V, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M, Billingham LK, Chia TY, Wei C, Rashidi A, Platanias LC, McCortney K, Horbinski CM, Stupp R, Zhang P, Ahmed AU, Sonabend AM, Heimberger AB, Lesniak MS, Riviere-Cazaux C, Burns T, Miska J, Fischietti M, Lee-Chang C. B cell-based therapy produces antibodies that inhibit glioblastoma growth. J Clin Invest. 2024 Aug 29; 134 (20)
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  28. Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley L, Chandler JP, Stupp R, Sonabend AM, Horbinski CM, Lukas RV, Xiu J, Lopez G, Nicolaides TP, Brown V, Wadhwani NR, Lam SK, James CD, Rao G, Castro MG, Heimberger AB, DeCuypere M. Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma. J Clin Invest. 2024 Aug 13; 134 (19)
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  29. Yang Y, Wadhwani N, Shimomura A, Zheng S, Chandler J, Lesniak MS, Tate MC, Sonabend AM, Kalapurakal J, Horbinski C, Lukas R, Stupp R, Kumthekar P, Sachdev S. Long-term outcomes of central neurocytoma - an institutional experience. J Neurooncol. 2024 Aug; 169 (1):195-201 Epub 2024 June 12
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  30. Ruda R, Horbinski C, van den Bent M, Preusser M, Soffietti R. IDH inhibition in gliomas: from preclinical models to clinical trials. Nat Rev Neurol. 2024 Jul; 20 (7):395-407 Epub 2024 May 17
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  31. Singer L, Singer J, Horbinski C, Penas-Prado M, Lukas RV. Immunotherapy for Solitary Fibrous Tumor (Hemangiopericytoma): A Unique Treatment Approach for a Rare Central Nervous System Tumor. Neurologist. 2024 Jul 1; 29 (4):250-253 Epub 2024 July 01
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  32. Ghorbani A, Chatanaka MK, Avery LM, Wang M, Brown J, Cohen R, Gorham T, Misaghian S, Padmanabhan N, Romero D, Stengelin M, Mathew A, Sigal G, Wohlstadter J, Horbinski C, McCortney K, Xu W, Zadeh G, Mansouri A, Yousef GM, Diamandis EP, Prassas I. Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers. Clin Proteomics. 2024 Jun 15; 21 (1):41 Epub 2024 June 15
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  33. Joy Trybula S, Nandoliya KR, Youngblood MW, Karras CL, Fernandez LG, Oyon DE, Texakalidis P, Khan OH, Lesniak MS, Tate MC, Rosenow JM, Hill VB, Hijaz TA, Russell EJ, Sachdev S, Kalapurakal JA, Horbinski CM, Magill ST, Chandler JP. Predictors of salvage therapy for parasagittal meningiomas treated with primary surgery, radiosurgery, or surgery plus adjuvant radiotherapy. J Clin Neurosci. 2024 Jun; 124:102-108 Epub 2024 Apr 28
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  34. Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A, Liu SJ, Phillips JJ, Magill ST, Horbinski CM, Solomon DA, Perry A, Vasudevan HN, Heimberger AB, Raleigh DR. Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution. Nat Genet. 2024 Jun; 56 (6):1121-1133 Epub 2024 May 17
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  35. Trybula SJ, Youngblood MW, Karras CL, Murthy NK, Heimberger AB, Lukas RV, Sachdev S, Kalapurakal JA, Chandler JP, Brat DJ, Horbinski CM, Magill ST. The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care. Cancers (Basel). 2024 Apr 30; 16 (9)
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  36. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K, Billingham LK, Miska J, Horbinski C, Lesniak MS, Chen P. Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression. Nat Commun. 2024 Mar 5; 15 (1):1987 Epub 2024 Mar 05
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  37. Tripathi S, Najem H, Dussold C, Pacheco S, Miska J, McCortney K, Steffens A, Walshon J, Winkowski D, Cloney M, Ordon M, Gibson W, Kemeny H, Youngblood M, Du R, Mossner J, Texakalidis P, Sprau A, Tate M, James CD, Horbinski CM, Wadhwani NR, Lesniak MS, Lam S, Sati A, Aghi M, DeCuypere M, Heimberger AB. Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas. J Clin Invest. 2024 Feb 15; 134 (4)
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  38. Arrieta VA, Duerinck J, Burdett KB, Habashy KJ, Geens W, Gould A, Schwarze JK, Dmello C, Kim KS, Saganty R, Chen L, Moscona A, McCord M, Lee-Chang C, Horbinski CM, Zhang H, Stupp R, Neyns B, Sonabend AM. ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis. Clin Cancer Res. 2024 Jan 17; 30 (2):379-388
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  39. Romay MC, Knutsen RH, Ma F, Mompeon A, Hernandez GE, Salvador J, Mirkov S, Batra A, Sullivan DP, Procissi D, Buchanan S, Kronquist E, Ferrante EA, Muller WA, Walshon J, Steffens A, McCortney K, Horbinski C, Tournier-Lasserve E, Sonabend AM, Sorond FA, Wang MM, Boehm M, Kozel BA, Iruela-Arispe ML. Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice. J Clin Invest. 2024 Jan 16; 134 (2)
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  40. Tripathi S, Nathan CL, Tate MC, Horbinski CM, Templer JW, Rosenow JM, Sita TL, James CD, Deneen B, Miller SD, Heimberger AB. The immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions. JCI Insight. 2024 Jan 9; 9 (1) Epub 2024 Jan 09
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  41. Gruchala T, Smith H, Khan O, Jennings L, Santana-Santos L, Vormittag-Nocito E, Horbinski C. Epithelial differentiation mimicking tumor-to-tumor metastasis in an isocitrate dehydrogenase wild-type glioblastoma. Neurooncol Adv. 2024 Jan-Dec; 6 (1):vdae081 Epub 2024 May 17
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  42. Najem H, Arrieta VA, Duffy J, Tripathi S, Zannikou M, Dhiantravan S, Miska J, McCortney K, Steffens A, Walshon J, Lee Chang C, Dahdaleh NS, Sonabend AM, Smith Z, Horbinski CM, Chandler J, Heimberger AB, Balyasnikova IV. Prohibitin Expression in Antigen-Presenting Cells: Implications for Inciting Trigger in CNS IgG4-Related Disease. Ann Case Rep. 2024; 9 (1) Epub 2024 Jan 25
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  43. Sadagopan NS, Nandoliya KR, Youngblood MW, Horbinski CM, Ahrendsen JT, Magill ST. A novel BRAF: PTPRN2 fusion in meningioma: a case report. Acta Neuropathol Commun. 2023; 11(194).
  44. Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T, Drumm M, McCortney K, Elemento O, Kim M, Bommi P, Low JT, Memon R, Wu J, Zhao J, Mi X, Glantz MJ, Sengupta S, Castro B, Yamini B, Horbinski C, Baker DJ, Walunas TL, Schiltz GE, Lukas RV, Wainwright DA. Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence. Clin Cancer Res. 2023 Dec 01; 29(23):4973-4989.
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  45. Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, Lam TC, Pu JK, Li LF, Leung GK, Chan JW, Perlow HK, Palmer JD, Haberler C, Berghoff AS, Preusser M, Nicolaides TP, Mawrin C, Agnihotri S, Resnick A, Rood BR, Chew J, Young JS, Boreta L, Braunstein SE, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer JE, Chandler JP, Solomon DA, Rogers CL, Pugh SL, Mehta MP, Sneed PK, Berger MS, Horbinski CM, McDermott MW, Perry A, Bi WL, Patel AJ, Sahm F, Magill ST, Raleigh DR. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat Med. 2023 Dec; 29 (12):3067-3076 Epub 2023 Nov 09
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  46. McCord M, Jamshidi P, Thirunavu V, Santana-Santos L, Vormittag-Nocito E, Dittman D, Parker S, Baczkowski J, Jennings L, Walshon J, McCortney K, Galbraith K, Zhang H, Lukas RV, Stupp R, Dixit K, Kumthekar P, Heimberger AB, Snuderl M, Horbinski C. Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results. Acta Neuropathol Commun. 2023 Nov 2; 11 (1):175 Epub 2023 Nov 02
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  47. Meredith DM, Cooley LD, Dubuc A, Morrissette J, Sussman RT, Nasrallah MP, Rathbun P, Yap KL, Wadhwani N, Bao L, Wolff DJ, Ida C, Sukhanova M, Horbinski C, Jennings LJ, Farooqi M, Gener M, Ginn K, Kam KL, Sasaki K, Kanagal-Shamanna R, Alexandrescu S, Brat D, Lu X. ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients. Mod Pathol. 2023 Nov; 36(11):100294. Epub 2023 Jul 31.
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  48. Murnan KM, Horbinski C, Stegh AH. Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma. Antioxid Redox Signal. 2023 Nov; 39 (13-15):923-941 Epub 2023 June 20
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  49. Youngblood MW, Erson-Omay Z, Li C, Najem H, Coskun S, Tyrtova E, Montejo JD, Miyagishima DF, Barak T, Nishimura S, Harmanci AS, Clark VE, Duran D, Huttner A, Avsar T, Bayri Y, Schramm J, Boetto J, Peyre M, Riche M, Goldbrunner R, Amankulor N, Louvi A, Bilguvar K, Pamir MN, Ozduman K, Kilic T, Knight JR, Simon M, Horbinski C, Kalamarides M, Timmer M, Heimberger AB, Mishra-Gorur K, Moliterno J, Yasuno K, Gunel M. Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas. Nat Commun. 2023 Oct 7; 14 (1):6279 Epub 2023 Oct 07
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  50. Stamm B, DiBiase R, Lee J, Primdahl D, Malavia T, Dixit K, Horbinski C, Kostelecky N, Elhodaky M, Potts MB, Caprio FZ, Bernstein RA, Urday S. A Woman With Multifocal Ischemic Strokes and Progressive Cognitive Impairment due to Intravascular Lymphoma. Stroke. 2023 Oct; 54 (10):e448-e451 Epub 2023 Aug 03
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  51. Pang L, Dunterman M, Guo S, Khan F, Liu Y, Taefi E, Bahrami A, Geula C, Hsu WH, Horbinski C, James CD, Chen P. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma. Nat Immunol. 2023 Oct; 24 (10):1654-1670 Epub 2023 Sept 04
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  52. Goenka A, Song X, Tiek D, Iglesia RP, Lu M, Zeng C, Horbinski C, Zhang W, Hu B, Cheng SY. Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis. Neuro Oncol. 2023 Sep 5; 25 (9):1592-1604
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  53. Zeng C, Song X, Zhang Z, Cai Q, Cai J, Horbinski C, Hu B, Cheng SY, Zhang W. Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis. Acta Neuropathol Commun. 2023 Aug 14; 11 (1):133
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  54. Jo J, Diaz M, Horbinski C, Mackman N, Bagley S, Broekman M, Rak J, Perry J, Pabinger I, Key NS, Schiff D. Epidemiology, biology, and management of venous thromboembolism in gliomas: An interdisciplinary review. Neuro Oncol. 2023 Aug 3; 25 (8):1381-1394
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  55. Alban TJ, Grabowski MM, Otvos B, Bayik D, Wang W, Zalavadia A, Makarov V, Troike K, McGraw M, Rabljenovic A, Lauko A, Neumann C, Roversi G, Waite KA, Cioffi G, Patil N, Tran TT, McCortney K, Steffens A, Diaz CM, Brown JM, Egan KM, Horbinski CM, Barnholtz-Sloan JS, Rajappa P, Vogelbaum MA, Bucala R, Chan TA, Ahluwalia MS, Lathia JD. The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma. JCI Insight. 2023 Jul 10; 8 (13) Epub 2023 July 10
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  56. Drumm MR, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb B, Byrne K, Unruh D, Thirunavu V, Walshon J, Steffens A, McCortney K, Lukas RV, Phillips JJ, Mohamed E, Finan JD, Santana-Santos L, Heimberger AB, Franz CK, Kurz J, Templer JW, Swanson GT, Horbinski C. Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors. J Clin Invest. 2023 Jun 15; 133 (12) Epub 2023 June 15
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  57. Zhang Y, Nguyen CC, Zhang NT, Fink NS, John JD, Venkatesh OG, Roe JD, Hoffman SC, Lesniak MS, Wolinsky JP, Horbinski C, Szymaniak BM, Buerki RA, Sosman JA, Shenoy NK, Lukas RV. Neurological applications of belzutifan in von Hippel-Lindau disease. Neuro Oncol. 2023 May 4; 25 (5):827-838
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  58. Baskaran AB, Dixit KS, Sonabend AM, Horbinski CM, Abutalib SA, Lukas RV. From the ER to the OR: Initial Evaluation of Primary Central Nervous System Lymphoma. Neurologist. 2023 May 1; 28 (3):135-142 Epub 2023 May 01
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  59. Ghorbani A, Avery LM, Sohaei D, Soosaipillai A, Richer M, Horbinski C, McCortney K, Xu W, Diamandis EP, Prassas I. Discovery of novel glioma serum biomarkers by proximity extension assay. Clin Proteomics. 2023 Mar 24; 20 (1):12
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  60. Burdett KB, Unruh D, Drumm M, Steffens A, Lamano J, Judkins J, Schwartz M, Javier R, Amidei C, Lipp ES, Peters KB, Lai A, Eldred BSC, Heimberger AB, McCortney K, Scholtens DM, Horbinski C. Determining venous thromboembolism risk in patients with adult-type diffuse glioma. Blood. 2023 Mar 16; 141 (11):1322-1336
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  61. Youngblood MW, Tran AN, Wang W, An S, Scholtens D, Zhang L, O'Shea K, Pokorny JL, Magill ST, Sachdev S, Lukas RV, Ahmed A, Unruh D, Walshon J, McCortney K, Wang Y, Baran A, Sahm F, Aldape K, Chandler JP, David James C, Heimberger AB, Horbinski C. Docetaxel targets aggressive methylation profiles and serves as a radiosensitizer in high-risk meningiomas. Neuro Oncol. 2023 Mar 14; 25 (3):508-519
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  62. Zannikou M, Duffy JT, Levine RN, Seblani M, Liu Q, Presser A, Arrieta VA, Chen CJ, Sonabend AM, Horbinski CM, Lee-Chang C, Miska J, Lesniak MS, Gottschalk S, Balyasnikova IV. IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM. J Immunother Cancer. 2023 Feb; 11 (2)
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  187. Xiong Z, Ampudia-Mesias E, Shaver R, Horbinski CM, Moertel CL, Olin MR. Tumor-derived vaccines containing CD200 inhibit immune activation: implications for immunotherapy. Immunotherapy. 2016 Sep; 8 (9):1059-71
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  200. Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23 (10):1985-96 Epub 2014 July 22
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  201. Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD. Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression. Stem Cells. 2014 Jul; 32 (7):1746-58
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  202. Collazo J, Zhu B, Larkin S, Martin SK, Pu H, Horbinski C, Koochekpour S, Kyprianou N. Cofilin drives cell-invasive and metastatic responses to TGF-beta in prostate cancer. Cancer Res. 2014 Apr 15; 74 (8):2362-73 Epub 2014 Feb 07
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  203. Convertini P, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S. Sudemycin E influences alternative splicing and changes chromatin modifications. Nucleic Acids Res. 2014 Apr; 42 (8):4947-61 Epub 2014 Mar 11
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  204. Gilbert MR, Liu Y, Neltner J, Pu H, Morris A, Sunkara M, Pittman T, Kyprianou N, Horbinski C. Autophagy and oxidative stress in gliomas with IDH1 mutations. Acta Neuropathol. 2014 Feb; 127 (2):221-33 Epub 2013 Oct 23
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  205. Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE, Alzheimer’ Disease Genetic Consortium, Schellenberg GD, Fardo DW. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 2014; 127(6):825-43. Epub 2014 Apr 27.
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  206. Miller TE, Wang J, Sukhdeo K, Horbinski C, Tesar PJ, Wechsler-Reya RJ, Rich JN. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS One. 2014; 9 (12):e114433 Epub 2014 Dec 10
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  207. Clark KH, Villano JL, Nikiforova MN, Hamilton RL, Horbinski C. 1p/19q testing has no significance in the workup of glioblastomas. Neuropathol Appl Neurobiol. 2013 Oct; 39 (6):706-17
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  208. Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 2013 Sep; 23(5):565-73. Epub 2013 Mar 18.
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  209. Horbinski C. What do we know about IDH1/2 mutations so far, and how do we use it? Acta Neuropathol. 2013 May; 125 (5):621-36 Epub 2013 Mar 20
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  210. Clark K, Voronovich Z, Horbinski C. How molecular testing can help (and hurt) in the workup of gliomas. Am J Clin Pathol. 2013 Mar; 139 (3):275-88
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  211. Burikhanov R, Shrestha-Bhattarai T, Qiu S, Shukla N, Hebbar N, Lele SM, Horbinski C, Rangnekar VM. Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4. Cancer Res. 2013 Jan 15; 73 (2):1011-9 Epub 2012 Nov 30
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  212. Horbinski C. To BRAF or not to BRAF: is that even a question anymore? J Neuropathol Exp Neurol. 2013 Jan; 72 (1):2-7
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  213. Horbinski C. Something old and something new about molecular diagnostics in gliomas. Surg Pathol Clin. 2012 Dec 1; 5 (4):919-939
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  214. Hanaoka BY, Peterson CA, Horbinski C, Crofford LJ. Implications of glucocorticoid therapy in idiopathic inflammatory myopathies. Nat Rev Rheumatol. 2012 Aug; 8 (8):448-57 Epub 2012 June 12
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  215. Hobbs J, Nikiforova MN, Fardo DW, Bortoluzzi S, Cieply K, Hamilton RL, Horbinski C. Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas. Am J Surg Pathol. 2012 Aug; 36 (8):1186-93
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  216. Liu Y, Komohara Y, Domenick N, Ohno M, Ikeura M, Hamilton RL, Horbinski C, Wang X, Ferrone S, Okada H. Expression of antigen processing and presenting molecules in brain metastasis of breast cancer. Cancer Immunol Immunother. 2012 Jun; 61 (6):789-801 Epub 2011 Nov 08
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  217. Horbinski C, Nikiforova MN, Hagenkord JM, Hamilton RL, Pollack IF. Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas. Neuro Oncol. 2012 Jun; 14 (6):777-89 Epub 2012 Apr 05
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  218. Horbinski C, Nikiforova MN, Hobbs J, Bortoluzzi S, Cieply K, Dacic S, Hamilton RL. The importance of 10q status in an outcomes-based comparison between 1p/19q fluorescence in situ hybridization and polymerase chain reaction-based microsatellite loss of heterozygosity analysis of oligodendrogliomas. J Neuropathol Exp Neurol. 2012 Jan; 71 (1):73-82
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  219. Horbinski C, Hobbs J, Cieply K, Dacic S, Hamilton RL. EGFR expression stratifies oligodendroglioma behavior. Am J Pathol. 2011 Oct; 179 (4):1638-44 Epub 2011 Aug 11
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  220. Horbinski C, Kofler J, Yeaney G, Camelo-Piragua S, Venneti S, Louis DN, Perry A, Murdoch G, Nikiforova M. Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol. 2011 Sep; 21 (5):564-74 Epub 2011 Mar 14
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  221. Horbinski C, Dillon D, Pittman T. Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy. Neuropathology. 2011 Jun; 31 (3):286-91 Epub 2010 Sept 29
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  222. Horbinski C, Miller CR, Perry A. Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade. Brain Pathol. 2011 Jan; 21 (1):57-73
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  223. Zhu ML, Horbinski CM, Garzotto M, Qian DZ, Beer TM, Kyprianou N. Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer. Cancer Res. 2010 Oct 15; 70 (20):7992-8002 Epub 2010 Aug 31
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  224. Horbinski C, Mojesky C, Kyprianou N. Live free or die: tales of homeless (cells) in cancer. Am J Pathol. 2010 Sep; 177 (3):1044-52 Epub 2010 July 16
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  225. Horbinski C, Oakley GJ, Cieply K, Mantha GS, Nikiforova MN, Dacic S, Seethala RR. The prognostic value of Ki-67, p53, epidermal growth factor receptor, 1p36, 9p21, 10q23, and 17p13 in skull base chordomas. Arch Pathol Lab Med. 2010 Aug; 134 (8):1170-6
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  226. Horbinski C, Kelly L, Nikiforov YE, Durso MB, Nikiforova MN. Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies. J Mol Diagn. 2010 Jul; 12 (4):487-92 Epub 2010 Apr 29
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  227. Horbinski C, Hamilton RL, Lovell C, Burnham J, Pollack IF. Impact of morphology, MIB-1, p53 and MGMT on outcome in pilocytic astrocytomas. Brain Pathol. 2010 May; 20 (3):581-8 Epub 2009 Sept 21
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  228. Horbinski C. Practical molecular diagnostics in neuropathology: making a tough job a little easier. Semin Diagn Pathol. 2010 May; 27 (2):105-13
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  229. Horbinski C, Hamilton RL, Nikiforov Y, Pollack IF. Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol. 2010 May; 119 (5):641-9 Epub 2010 Jan 01
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  230. Horbinski C, Wang G, Wiley CA. YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. Int J Clin Exp Pathol. 2010 Jan 1; 3 (3):226-37 Epub 2010 Jan 01
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  231. Horbinski C, Kofler J, Kelly LM, Murdoch GH, Nikiforova MN. Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. J Neuropathol Exp Neurol. 2009 Dec; 68 (12):1319-25
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  232. Horbinski C, Wiley CA. Comparison of telepathology systems in neuropathological intraoperative consultations. Neuropathology. 2009 Dec; 29 (6):655-63 Epub 2009 Apr 21
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  233. Horbinski C, Dacic S, McLendon RE, Cieply K, Datto M, Brat DJ, Chu CT. Chordoid glioma: a case report and molecular characterization of five cases. Brain Pathol. 2009 Jul; 19 (3):439-48 Epub 2008 July 23
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  234. Horbinski C, Hamilton RL. Application of telepathology for neuropathologic intraoperative consultations. Brain Pathol. 2009 Apr; 19 (2):317-22
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  235. Horbinski C, Bartynski WS, Carson-Walter E, Hamilton RL, Tan HP, Cheng S. Reversible encephalopathy after cardiac transplantation: histologic evidence of endothelial activation, T-cell specific trafficking, and vascular endothelial growth factor expression. AJNR Am J Neuroradiol. 2009 Mar; 30 (3):588-90 Epub 2008 Oct 14
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  236. Horbinski C, Carter EM, Heard PL, Sathanoori M, Hu J, Vockley J, Gunn S, Hale DE, Surti U, Cody JD. Molecular and clinical characterization of a recurrent cryptic unbalanced t(4q;18q) resulting in an 18q deletion and 4q duplication. Am J Med Genet A. 2008 Nov 15; 146A (22):2898-904
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  237. Horbinski C, Cieply K, Bejjani GK, McFadden K. Primary intracranial dural-based synovial sarcoma with an unusual SYT fluorescence in situ hybridization pattern. J Neurosurg. 2008 Nov; 109 (5):897-903
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  238. Striebel JM, Bhargava R, Horbinski C, Surti U, Dabbs DJ. The equivocally amplified HER2 FISH result on breast core biopsy: indications for further sampling do affect patient management. Am J Clin Pathol. 2008 Mar; 129 (3):383-90
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  239. Horbinski C, Fine JL, Medina-Flores R, Yagi Y, Wiley CA. Telepathology for intraoperative neuropathologic consultations at an academic medical center: a 5-year report. J Neuropathol Exp Neurol. 2007 Aug; 66 (8):750-9
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  240. Kulich SM, Horbinski C, Patel M, Chu CT. 6-Hydroxydopamine induces mitochondrial ERK activation. Free Radic Biol Med. 2007 Aug 1; 43 (3):372-83 Epub 2007 Apr 29
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  241. Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol. 2007 Jan; 170 (1):75-86
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  242. Horbinski C, Chu CT. Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radic Biol Med. 2005 Jan 1; 38 (1):2-11
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  243. Kim WY, Horbinski C, Sigurdson W, Higgins D. Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons. J Neurochem. 2004 Dec; 91 (5):1044-56
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  244. Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM. DMT1: a mammalian transporter for multiple metals. Biometals. 2003 Mar; 16 (1):41-54
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  245. Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology. 2002 Jul; 23 (2):147-57
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  246. Horbinski C, Stachowiak EK, Chandrasekaran V, Miuzukoshi E, Higgins D, Stachowiak MK. Bone morphogenetic protein-7 stimulates initial dendritic growth in sympathetic neurons through an intracellular fibroblast growth factor signaling pathway. J Neurochem. 2002 Jan; 80 (1):54-63
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  247. Dattatreyamurty B, Roux E, Horbinski C, Kaplan PL, Robak LA, Beck HN, Lein P, Higgins D, Chandrasekaran V. Cerebrospinal fluid contains biologically active bone morphogenetic protein-7. Exp Neurol. 2001 Dec; 172 (2):273-81
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  248. Guo X, Lin Y, Horbinski C, Drahushuk KM, Kim IJ, Kaplan PL, Lein P, Wang T, Higgins D. Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity. J Neurobiol. 2001 Aug; 48 (2):120-30
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  249. Horbinski C, Stachowiak MK, Higgins D, Finnegan SG. Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina. BMC Neurosci. 2001; 2:2 Epub 2001 Feb 16
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  250. Roth JA, Horbinski C, Feng L, Dolan KG, Higgins D, Garrick MD. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. J Neurosci. 2000 Oct 15; 20 (20):7595-601
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