Clinical Trials A continuación, se enumeran los ensayos clínicos actuales.35 estudios en Ophthalmology (solo estudios abiertos). Filtra esta lista de estudios por sede, estado, etc. Exparel Injection for Postoperative Orbital Pain Rochester, Minn. After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration. A Study to Evaluate Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) Imaging In Supine Patient Rochester, Minn. The purpose of this study is to determine if a relay lens and right angle mirror can be used in conjunction with an FDA-approved optical coherence tomography (OCT) unit to allow imaging in supine patients. Intraocular Pressure in Ocular Hypertensives with Scleral Lens Wear Rochester, Minn. The purpose of this study is to determine if short-term wear of a scleral contact lens will raise intraocular pressure in ocular hypertensive patients. A Study to Evaluate the Safety and Effectiveness of Intratumoral and Intravenous Injection of Vesicular Stomatitis Virus Expressing Human Interferon Beta, and Tyrosinase Related Protein 1 (VSV-IFNb-TYRP1) in Patients with Metastatic Ocular Melanoma and Previously Treated Patients with Unresectable Stage III/IV Cutaneous Melanoma Jacksonville, Fla., Rochester, Minn. The purpose of this study is to determine the safety profile and maximum tolerated dose (MTD) of VSV-IFNß-TYRP1 therapy when administered by IV and IT injection in patients with previously treated metastatic melanoma. A Study to Assess for Changes in Optic Nerve Structure and Function due to Changes in Cerebrospinal Fluid Pressure Rochester, Minn. The purpose of this study is to assess for changes in the structure and function of the optic nerve caused by changes in cerebrospinal fluid pressure. A Study of Video-Oculography to Noninvasively Record Eye Movements in Patients with Strabismus and Nystagmus. Rochester, Minn. The purpose of this study is to evaluate changes in torsional eye position that accompany strabismus and nystagmus. These changes, which cannot be visualized on clinical examination, will provide new information about the neurophysiology of these ocular motor disturbances. Evaluating Optic Nerve Disease with OCT Angiography Rochester, Minn. The purpose of this study is to determine if optical coherence tomography (OCT) angiography is able to distinguish different causes of optic neuropathy. A Study to Assess the Effectiveness and Safety of Intravitreal 440 ug DE-109 Sirolimus Injections for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye Jacksonville, Fla. The purpose of this study is to assess the effectiveness and safety of DE-109 440 µg every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month double- masked, controlled period allows the evaluation of the efficacy and safety of intravitreal injection of DE-109 440 µg every 2 months for longer duration than appropriate for a placebo or sham control. Outcome Measures for Clinical Trials in Pediatric Eye Care and Strabismus Rochester, Minn. This study is being done to: - Assess what children with different eye conditions experience in everyday life - Improve our understanding of the difficulties that children with eye problems experience - Improve reporting of how parents see their child’s eye condition affecting them - Assess what parents of children with different eye conditions experience in their own everyday life - Improve the way we assess the benefits of treatment Glasses for Adolescent Delayed Sleep-Wake Phase Disorder (GLAD) Rochester, Minn. The purpose of this study is to determine if evening amber glasses combined with stable wake times will show an increase in total sleep time (TST), and an advance in sleep onset times (shift earlier) compared to the control group. Numeración de páginas Estudios clínicos AnteriorPágina anterior Ir a página 11 Ir a página 22 Ir a página 33 Ir a página 44 SiguientePróxima página Profesionales médicos Ophthalmology clinical-trials