Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of canagliflozin and metformin combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of canagliflozin and metformin combination in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving canagliflozin and metformin combination.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Acetazolamide
  • Alogliptin
  • Aspirin
  • Bexagliflozin
  • Bictegravir
  • Brinzolamide
  • Bupropion
  • Capmatinib
  • Chloroquine
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Cimetidine
  • Ciprofloxacin
  • Cyclosporine
  • Dasabuvir
  • Delafloxacin
  • Diatrizoate
  • Dichlorphenamide
  • Digoxin
  • Dofetilide
  • Dolutegravir
  • Dorzolamide
  • Enoxacin
  • Ethiodized Oil
  • Fedratinib
  • Fexinidazole
  • Furosemide
  • Gatifloxacin
  • Gemifloxacin
  • Glimepiride
  • Glipizide
  • Glyburide
  • Grepafloxacin
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Hydroxychloroquine
  • Indapamide
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Iodipamide
  • Iodixanol
  • Iohexol
  • Iopamidol
  • Iopanoic Acid
  • Iopromide
  • Iothalamate
  • Iotrolan
  • Ioversol
  • Ioxaglate
  • Ipodate
  • Isavuconazole
  • Lanreotide Acetate
  • Levofloxacin
  • Levoketoconazole
  • Liraglutide
  • Lithium
  • Lomefloxacin
  • Methazolamide
  • Metolazone
  • Metrizamide
  • Moxifloxacin
  • Nateglinide
  • Norfloxacin
  • Octreotide Acetate
  • Ofloxacin
  • Ombitasvir
  • Paritaprevir
  • Pasireotide Diaspartate
  • Pioglitazone
  • Polythiazide
  • Pramlintide
  • Ranolazine
  • Repaglinide
  • Repotrectinib
  • Semaglutide
  • Sitagliptin
  • Somatrogon-ghla
  • Sotagliflozin
  • Sparfloxacin
  • Tafenoquine
  • Thioctic Acid
  • Tolazamide
  • Tolbutamide
  • Topiramate
  • Triamterene
  • Trovafloxacin
  • Vandetanib
  • Zonisamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Bitter Melon
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Colesevelam
  • Esmolol
  • Fenugreek
  • Glecaprevir
  • Glucomannan
  • Goldenseal
  • Guar Gum
  • Hydrastis
  • Isocarboxazid
  • Labetalol
  • Levobunolol
  • Linezolid
  • Methylene Blue
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Ozanimod
  • Patiromer
  • Penbutolol
  • Phenelzine
  • Pibrentasvir
  • Pindolol
  • Practolol
  • Procarbazine
  • Propranolol
  • Psyllium
  • Rasagiline
  • Rifampin
  • Safinamide
  • Selegiline
  • Sotalol
  • Timolol
  • Tirzepatide
  • Tranylcypromine
  • Verapamil

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Adrenal gland problem (underactive) or
  • Alcohol use disorder, history of or
  • Congestive heart failure or
  • Dehydration, severe or
  • Hypovolemia (low blood volume) or
  • Pancreatic insulin deficiency or pancreatic disorder (eg, pancreatitis, pancreatic surgery), history of or
  • Pituitary gland problem (underactive) or
  • Poorly nourished condition or
  • Sepsis (severe infection) or
  • Weakened physical condition—Use with caution. May cause side effects to become worse.
  • Anemia (low red blood cells) or
  • Dehydration or
  • Genital yeast (fungus) infection (eg, balanitis, balanoposthitis, vulvovaginitis), history of or
  • Hyperkalemia (high potassium in the blood) or
  • Hypotension (low blood pressure) or
  • Kidney disease or
  • Urinary tract infection (eg, pyelonephritis, urosepsis), history of or
  • Vitamin B12 deficiency—Use with caution. May make these conditions worse.
  • Blood vessel disease or
  • Diabetic foot ulcer or
  • Leg amputation (leg removal surgery), history of or
  • Neuropathy (nerve problem) of the leg—May increase the risk of leg amputations.
  • Diabetic ketoacidosis (high ketones and acid in the blood) or
  • Kidney disease, severe or
  • Liver disease or
  • Metabolic acidosis (acid in the blood) or
  • Type I diabetes—Should not be used in patients with these conditions.
  • Fever or
  • Infection or
  • Surgery or
  • Trauma—Use with caution. These conditions may cause problems with blood sugar control.
  • Hypoxia (low oxygen in the blood) or
  • Kidney damage or
  • Liver damage or
  • Radiologic procedures (eg, X-rays, CT scans, MRIs) that require dyes to be injected into your vein—May increase your risk for lactic acidosis (too much acid in the blood).

Portions of this document last updated: May 01, 2024

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