Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Because of tetracycline's toxicity, use in children 8 years of age and younger is not recommended. Tetracycline may cause permanent discoloration of the teeth and slow down the growth of bones. Safety and efficacy have not been established in this age group.

Geriatric

Although appropriate studies on the relationship of age to the effects of Helidac® have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acitretin
  • Amprenavir
  • Bepridil
  • Cisapride
  • Disulfiram
  • Dronabinol
  • Dronedarone
  • Levoketoconazole
  • Mesoridazine
  • Methoxyflurane
  • Pimozide
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Adagrasib
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amoxicillin
  • Ampicillin
  • Amtolmetin Guacil
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bacampicillin
  • Balsalazide
  • Bedaquiline
  • Bexarotene
  • Bromfenac
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Busulfan
  • Capecitabine
  • Celecoxib
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Cholera Vaccine, Live
  • Choline Magnesium Trisalicylate
  • Choline Salicylate
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clonixin
  • Clothiapine
  • Cloxacillin
  • Clozapine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desogestrel
  • Deutetrabenazine
  • Dexibuprofen
  • Dexketoprofen
  • Dexmedetomidine
  • Dicloxacillin
  • Dienogest
  • Diflunisal
  • Digoxin
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxifluridine
  • Droperidol
  • Drospirenone
  • Droxicam
  • Ebastine
  • Efavirenz
  • Encorafenib
  • Entrectinib
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etretinate
  • Famotidine
  • Felbamate
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluorouracil
  • Fluoxetine
  • Flurbiprofen
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Furosemide
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gestodene
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibuprofen
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Inotuzumab Ozogamicin
  • Isotretinoin
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Levonorgestrel
  • Lithium
  • Lofexidine
  • Lornoxicam
  • Loxoprofen
  • Lumefantrine
  • Lumiracoxib
  • Macimorelin
  • Magnesium Salicylate
  • Magnesium Sulfate
  • Mebendazole
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Mesalamine
  • Mestranol
  • Methadone
  • Methicillin
  • Methotrexate
  • Methotrimeprazine
  • Mifepristone
  • Mizolastine
  • Mobocertinib
  • Moricizine
  • Morniflumate
  • Moxifloxacin
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nabumetone
  • Nafarelin
  • Nafcillin
  • Naproxen
  • Nelfinavir
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nomegestrol
  • Norethindrone
  • Norfloxacin
  • Norgestimate
  • Norgestrel
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olsalazine
  • Ondansetron
  • Osimertinib
  • Oxacillin
  • Oxaliplatin
  • Oxaprozin
  • Oxyphenbutazone
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Palovarotene
  • Panobinostat
  • Papaverine Hydrochloride
  • Parecoxib
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Procaine
  • Penicillin V
  • Pentamidine
  • Perphenazine
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Phenyl Salicylate
  • Phenytoin
  • Piketoprofen
  • Pimavanserin
  • Pipamperone
  • Piperacillin
  • Piperaquine
  • Piroxicam
  • Pitolisant
  • Pivampicillin
  • Ponesimod
  • Porfimer
  • Posaconazole
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Proglumetacin
  • Promethazine
  • Propafenone
  • Propyphenazone
  • Proquazone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Relugolix
  • Ribociclib
  • Risperidone
  • Ritonavir
  • Rofecoxib
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sodium Salicylate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sulfasalazine
  • Sulindac
  • Sulpiride
  • Sultamicillin
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tegafur
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Temocillin
  • Tenoxicam
  • Tetrabenazine
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Tolterodine
  • Toremifene
  • Trazodone
  • Tretinoin
  • Trimipramine
  • Triptorelin
  • Trolamine Salicylate
  • Valdecoxib
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Aminolevulinic Acid
  • Atovaquone
  • Calcium
  • Carbamazepine
  • Cholestyramine
  • Colestipol
  • Cyclosporine
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Doxycycline
  • Iron
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate
  • Milk Thistle
  • Omadacycline
  • Probenecid
  • Quinine
  • Sulfinpyrazone
  • Tamarind

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Dairy Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to aspirin or other salicylates or
  • Cockayne Syndrome (genetic disorder) or
  • Kidney disease, severe—Should not be used in patients with these conditions.
  • Blood disorder (eg, leukopenia, neutropenia), or history of or
  • Fungal infection (eg, candidiasis)—Use with caution. May make these conditions worse.
  • Chickenpox or
  • Influenza—Use with caution. May increase risk of Reye's syndrome in children with or recovering from these conditions.
  • Intracranial hypertension (high fluid pressure in the brain), history of or
  • Obesity—Use with caution. May increase risk of developing intracranial hypertension or pseudotumor cerebri caused by tetracycline.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of metronidazole and tetracycline from the body.

Portions of this document last updated: March 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.