Proper Use

Información sobre medicamentos proporcionada por: IBM Micromedex

A nurse or other trained health professional may give you this medicine. It is given as a shot under the skin of your upper arm, buttock, stomach, or thigh. Do not inject this medicine into the buttocks for infants.

You may be taught how to give this medicine at home. Make sure you understand all of the instructions before giving yourself or your child an injection. Do not use more medicine or use it more often than your doctor tells you to.

This medicine comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions about:

  • How to prepare the injection.
  • The proper use of disposable syringes.
  • How to give the injection.
  • How long the injection can be stored at home.

Allow this medicine to warm to room temperature for at least 15 to 30 minutes before you use it. Do not warm it in any other way.

Check the liquid in the vial. It should be clear or slightly yellow and may have a few small white particles in it. Do not use the medicine if the liquid is discolored or has lumps or large particles in it. Do not shake the vial.

Use the vial only once. Do not save leftover medicine.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injectable dosage form (solution):
    • For perinatal, infantile, and juvenile-onset hypophosphatasia:
      • Children weighing 3 to 80 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 milligrams (mg) per kg (mg/kg) per week (given either as 2 mg/kg three times a week or 1 mg/kg six times a week) given as a shot under the skin.
      • Children weighing less than 3 kg—Use and dose must be determined by your doctor.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Use the vial within 3 hoursafter removing it from the refrigerator. Throw away any unused medicine.

Throw away used needles in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.