Radiología

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estatus, etc.

1. A Study of Lutetium Lu 177 Dotatate (Lutathera®) in Patients with Inoperable, Progressive Meningioma after External Beam Radiation Therapy

   Rochester, Minn.

   The purpose of this study is to estimate the efficacy of LUTATHERA treatment in patients with recurrent grade 1 meningioma as measured by 6-month PFS rate, and to estimate the efficacy of LUTATHERA treatment in patients with recurrent grade 2 or 3 meningioma as measured by 6-month PFS rate.

    

2. A Study of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction

   Jacksonville, Fla.

   The purpose of this study is to establish a registry that will address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction) between ED (Emergency Department) arrival and diagnostic angiography in detail, by characterizing and following the ED and peri-ED use of advanced OAP (Oral Anti-Platelet) agents. In addition to exploring ED treatment patterns and success of both ischemic and bleeding risk stratification prior to definition of the coronary anatomy, data generated via the UPSTREAM registry will allow plausible attribution of ischemic and bleeding outcomes to pre-catheterization antiplatelet therapy in the management of NSTEMI. This registry further seeks to demonstrate that contemporary use of upstream ticagrelor is associated with an economically-sound utilization of hospital resources, and smooth transition of care into the outpatient, secondary prevention setting for the first 30 days after hospitalization. Finally, it will allow characterization of patient selection factors and processes for ticagrelor vs alternative OAP agents, carrying out that descriptive comparison through discharge. Patients transferred in to an UPSTREAM hospital are eligible for inclusion, but the timing for OAP agent administration and diagnostic catheterization begin with ED care at the first hospital.

3. A Study to Evaluate Ultrasound Microvessel Imaging

   Rochester, Minn.

   The purpose of this study is to find out the optimal acquisition parameters for ultrasound microvessel imaging in healthy volunteers. 

4. Medical and Resource Facilitation Intervention After Traumatic Brain Injury (MRFI)

   Rochester, Minn.

   The purpose of this study is to determine if there are changes in mild traumatic brain injury (mTBI) and/or repetitive head impacts (RHI) detectible with multiparametric MR Elastography (MRE). The hypothesis is that multiparametric MR Elastography will detect changes in the mechanical properties of human head tissues in patients following head traumas.

    

5. MR Elastography of Hydrocephalus

   Rochester, Minn.

   We are doing this research study to develop and test the effectiveness of a new imaging technique called magnetic resonance elastography (MRE). This technique measures the stiffness (mechanical properties) of the brain and cerebral spinal fluid.

6. A Study to Evaluate MR of CSF Dynamics

   Rochester, Minn.

   The purpose of this study is to evaluate changes in CSF dynamics (e.g., velocity, flow rate) between patients with normal pressure hydrocephalus and healthy controls, as well as patients with other dementia disorders.

7. Evaluation of the Total Kidney Volume AI Algorithm

   Rochester, Minn.

   The natural course of autosomal dominant polycystic kidney disease (ADPKD) is highly variable and typically characterized by progressive enlargement of cysts within the kidneys.  ADPKD is a leading cause of end-stage renal disease.  Recently, a new medication called Tolvaptan has been approved by the FDA to slow progression of ADPKD.  Accurate, MR based kidney volume measurements are the best parameter for following the progression of ADPKD, and are suggested be acquired to measure progression and effects of Tolvaptan.  However, making these slice-by-slice volume measurements can be extremely time consuming when done manually.  The purpose of this work is to evaluate an AI algorithm to make the measurements.  The results of the algorithm will be reviewed by a qualified radiologist familiar with the algorithm’s results.  If the radiologist agrees with the results, kidney volumes (left, right and combined) will be recorded for clinical use.  The usage of the algorithm in this setting (with review by radiologist, and manual correction) is a minimal risk to the patients: a failure of the algorithm will have no impact on treatment and errors will be caught and corrected by the QC process. Because the algorithm will not be used solely for diagnosis or inform treatment without the confirmation of the diagnosis by another, medically established diagnostic product or procedure this study constitutes minimal risk to patients. 

8. Minnesota Spinal Cord Injury Data Network

   Rochester, Minn.

   This is a study to generate feasibilty data regarding the collection of health and psychosocial outcomes after acquired spinal cord injury (SCI)

9. A Study to Evaluate the Effects of Distortion Reduction Software for Improving Image Quality in Computed Tomography (CT) Scans

   Rochester, Minn.

   The primary purpose of this study is to evaluate the effectiveness of automatic adaptive iterative metal artifcate reduction (AiMAR) in improving image quality in CT scans of different body parts in patients with different metal implants in terms of artifact reduction and visualization of key anatomic structures.

10. A Study of Endovascular Biopsy and Endothelial Cell Gene Analysis in Endovascular Procedures

    Rochester, Minn.

    The purpose of this study is to determine endothelial gene expression from guidewire biopsy during clinically indicated endovascular procedures. The genetic analysis will be measured against clinical outcomes and treatment response (response to non-coated and drug-coated technologies and different embolic agents depending on the procedure).

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estatus, etc.

1. A Study of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction

   Jacksonville, Fla.

   The purpose of this study is to establish a registry that will address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction) between ED (Emergency Department) arrival and diagnostic angiography in detail, by characterizing and following the ED and peri-ED use of advanced OAP (Oral Anti-Platelet) agents. In addition to exploring ED treatment patterns and success of both ischemic and bleeding risk stratification prior to definition of the coronary anatomy, data generated via the UPSTREAM registry will allow plausible attribution of ischemic and bleeding outcomes to pre-catheterization antiplatelet therapy in the management of NSTEMI. This registry further seeks to demonstrate that contemporary use of upstream ticagrelor is associated with an economically-sound utilization of hospital resources, and smooth transition of care into the outpatient, secondary prevention setting for the first 30 days after hospitalization. Finally, it will allow characterization of patient selection factors and processes for ticagrelor vs alternative OAP agents, carrying out that descriptive comparison through discharge. Patients transferred in to an UPSTREAM hospital are eligible for inclusion, but the timing for OAP agent administration and diagnostic catheterization begin with ED care at the first hospital.

2. A Study to Evaluate Ultrasound Microvessel Imaging

   Rochester, Minn.

   The purpose of this study is to find out the optimal acquisition parameters for ultrasound microvessel imaging in healthy volunteers. 

3. A Study to Evaluate Noninvasive Ultrasound Elastography of Kidney and Lung in Assessment of Volume Status in ICU Patients

   Rochester, Minn.

   The primary purpose of this study is to assess the feasibility of performing lung and kidney and lung ultrasound elastography among patients with critical illness from different etiologies that could be associated with volume overload.

4. Medical and Resource Facilitation Intervention After Traumatic Brain Injury (MRFI)

   Rochester, Minn.

   The purpose of this study is to determine if there are changes in mild traumatic brain injury (mTBI) and/or repetitive head impacts (RHI) detectible with multiparametric MR Elastography (MRE). The hypothesis is that multiparametric MR Elastography will detect changes in the mechanical properties of human head tissues in patients following head traumas.

    

5. MR Elastography of Hydrocephalus

   Rochester, Minn.

   We are doing this research study to develop and test the effectiveness of a new imaging technique called magnetic resonance elastography (MRE). This technique measures the stiffness (mechanical properties) of the brain and cerebral spinal fluid.

6. A Study to Evaluate MR of CSF Dynamics

   Rochester, Minn.

   The purpose of this study is to evaluate changes in CSF dynamics (e.g., velocity, flow rate) between patients with normal pressure hydrocephalus and healthy controls, as well as patients with other dementia disorders.

7. Evaluation of the Total Kidney Volume AI Algorithm

   Rochester, Minn.

   The natural course of autosomal dominant polycystic kidney disease (ADPKD) is highly variable and typically characterized by progressive enlargement of cysts within the kidneys.  ADPKD is a leading cause of end-stage renal disease.  Recently, a new medication called Tolvaptan has been approved by the FDA to slow progression of ADPKD.  Accurate, MR based kidney volume measurements are the best parameter for following the progression of ADPKD, and are suggested be acquired to measure progression and effects of Tolvaptan.  However, making these slice-by-slice volume measurements can be extremely time consuming when done manually.  The purpose of this work is to evaluate an AI algorithm to make the measurements.  The results of the algorithm will be reviewed by a qualified radiologist familiar with the algorithm’s results.  If the radiologist agrees with the results, kidney volumes (left, right and combined) will be recorded for clinical use.  The usage of the algorithm in this setting (with review by radiologist, and manual correction) is a minimal risk to the patients: a failure of the algorithm will have no impact on treatment and errors will be caught and corrected by the QC process. Because the algorithm will not be used solely for diagnosis or inform treatment without the confirmation of the diagnosis by another, medically established diagnostic product or procedure this study constitutes minimal risk to patients. 

8. Minnesota Spinal Cord Injury Data Network

   Rochester, Minn.

   This is a study to generate feasibilty data regarding the collection of health and psychosocial outcomes after acquired spinal cord injury (SCI)

9. A Study to Evaluate the Effects of Distortion Reduction Software for Improving Image Quality in Computed Tomography (CT) Scans

   Rochester, Minn.

   The primary purpose of this study is to evaluate the effectiveness of automatic adaptive iterative metal artifcate reduction (AiMAR) in improving image quality in CT scans of different body parts in patients with different metal implants in terms of artifact reduction and visualization of key anatomic structures.

10. A Study of Endovascular Biopsy and Endothelial Cell Gene Analysis in Endovascular Procedures

    Rochester, Minn.

    The purpose of this study is to determine endothelial gene expression from guidewire biopsy during clinically indicated endovascular procedures. The genetic analysis will be measured against clinical outcomes and treatment response (response to non-coated and drug-coated technologies and different embolic agents depending on the procedure).