Medicina del dolor

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estatus, etc.

1. A Study to Analyze the Effects of Buprenorphine on Hyperalgesia in Patients with Opioid Use Disorder

   Rochester, Minn.

   The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).

2. Chronic Pain Biobank

   Jacksonville, Fla.

   The purpose of this study is to create a biorepository for samples of chronic pain patients.

3. A Study to Analyze the Effects of Exparel for Post-Surgery Pain Control in Patients Undergoing Penile Prosthesis Placement

   Rochester, Minn.

   The purpose of this study is to determine the effects of liposomal bupivacaine vs lidocaine/bupivacaine mixture in patients’ undergoing surgical placement of a penile prosthesis.

4. Resting State Connectivity in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Pain

   Rochester, Minn.

   The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

5. A Study to Assess Study Design and Potential Willingness to Participate in a Future Study of Opioid Tapering

   Eau Claire, Wis., Rochester, Minn.

   The purpose of this study is to administer a survey to elicit interest in participating in a future proposed trial involving a very slow tapering of opioid medications (approximately 10% dose reduction every month) for up to 12 months.

6. A Study of Serum Baclofen Levels in Patients with Intrathecal Baclofen Therapy

   Rochester, Minn.

   The purpose of this study is to determine serum levels of baclofen in patients with spasticity managed with long-term intrathecal baclofen therapy. 

7. Analysis of Orthobiologic Agents (OBA) for Painful Musculoskeletal Conditions and Tissue Regeneration

   Jacksonville, Fla.

   The objectives of this study are to determine the effect of patient factors and manufacturing procedures on OBA product characteristics, to assess the clinical outcomes of patients affected by multiple painful musculoskeletal disorders and tissue regeneration needs that are treated with guided procedures in the Mayo Clinic Pain practice, to assess genetic and epigenetic factors associated to multiple painful musculoskeletal disorders and tissue regeneration needs, to determine the effect of OBA characteristics on patient outcomes for patients treated with OBA procedures, including a reference group of patients not receiving OBAs as part of their medical care.

8. Effect of Opioid Use and Fibromyalgia on Steroid Metabolome and Adrenal Function

   Rochester, Minn.

   The purpose of this study is to determine the abnormalities in urine steroid profiling and association to the daily opioid dose in patients treated with opioids as compared to the existent cohort of healthy controls, and to identify the steroid signature associated with low quality of life, including physical and mental health.

9. A Study to Evaluate Prevalence of Secondary Adrenal Insufficiency in Patients with Chronic Pain

   Jacksonville, Fla.

   The purpose of this study is to evaluate the hormonal profile related to opioed induced adrenal insufficency (OIAI) in chronic pain patients that completed the 3-weeks Interdisciplinary Pain Rehabilitaion Program (IPRP) at the Pain Rehabilitation Center (PRC) at Mayo Clinic / Florida.

10. A Study to Evaluate Analgesic Use and Duration for Pediatric Long Bone Fractures

    Rochester, Minn.

    The purpose of this study is to develop an evidenced-based guideline for pediatric opioid prescribing guideline from the emergency department for long bone fractures to more closely tailor pain management to abuse potential. 

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estatus, etc.

1. A Study to Analyze the Effects of Buprenorphine on Hyperalgesia in Patients with Opioid Use Disorder

   Rochester, Minn.

   The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).

2. Chronic Pain Biobank

   Jacksonville, Fla.

   The purpose of this study is to create a biorepository for samples of chronic pain patients.

3. A Study to Analyze the Effects of Exparel for Post-Surgery Pain Control in Patients Undergoing Penile Prosthesis Placement

   Rochester, Minn.

   The purpose of this study is to determine the effects of liposomal bupivacaine vs lidocaine/bupivacaine mixture in patients’ undergoing surgical placement of a penile prosthesis.

4. Resting State Connectivity in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Pain

   Rochester, Minn.

   The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

5. A Study to Assess Study Design and Potential Willingness to Participate in a Future Study of Opioid Tapering

   Eau Claire, Wis., Rochester, Minn.

   The purpose of this study is to administer a survey to elicit interest in participating in a future proposed trial involving a very slow tapering of opioid medications (approximately 10% dose reduction every month) for up to 12 months.

6. A Study of Serum Baclofen Levels in Patients with Intrathecal Baclofen Therapy

   Rochester, Minn.

   The purpose of this study is to determine serum levels of baclofen in patients with spasticity managed with long-term intrathecal baclofen therapy. 

7. Analysis of Orthobiologic Agents (OBA) for Painful Musculoskeletal Conditions and Tissue Regeneration

   Jacksonville, Fla.

   The objectives of this study are to determine the effect of patient factors and manufacturing procedures on OBA product characteristics, to assess the clinical outcomes of patients affected by multiple painful musculoskeletal disorders and tissue regeneration needs that are treated with guided procedures in the Mayo Clinic Pain practice, to assess genetic and epigenetic factors associated to multiple painful musculoskeletal disorders and tissue regeneration needs, to determine the effect of OBA characteristics on patient outcomes for patients treated with OBA procedures, including a reference group of patients not receiving OBAs as part of their medical care.

8. Effect of Opioid Use and Fibromyalgia on Steroid Metabolome and Adrenal Function

   Rochester, Minn.

   The purpose of this study is to determine the abnormalities in urine steroid profiling and association to the daily opioid dose in patients treated with opioids as compared to the existent cohort of healthy controls, and to identify the steroid signature associated with low quality of life, including physical and mental health.

9. A Study to Evaluate Prevalence of Secondary Adrenal Insufficiency in Patients with Chronic Pain

   Jacksonville, Fla.

   The purpose of this study is to evaluate the hormonal profile related to opioed induced adrenal insufficency (OIAI) in chronic pain patients that completed the 3-weeks Interdisciplinary Pain Rehabilitaion Program (IPRP) at the Pain Rehabilitation Center (PRC) at Mayo Clinic / Florida.

10. A Study to Evaluate Analgesic Use and Duration for Pediatric Long Bone Fractures

    Rochester, Minn.

    The purpose of this study is to develop an evidenced-based guideline for pediatric opioid prescribing guideline from the emergency department for long bone fractures to more closely tailor pain management to abuse potential.