Neurología

A continuación se enumeran ensayos clínicos actuales.

Filtrar esta lista de estudios según la ubicación, el estado del estudio y más.

1. A Study to Develop a Large-Scale Long-Term Database of Headache Disorders

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to enroll in a registry patients who have headache disorders, collecting detailed headache characteristics, biospecimens, and brain imaging data, to allow for more research into accurate diagnosis, prognosis, and treatments.

2. A Study of Congenital Myasthenic Syndromes

   Rochester, Minn.

   The proposed studies are important for diagnosis and prevention of congenital myasthenic syndromes (CMS), for investigating disease pathophysiology, for developing strategies for therapy, and for gaining insights into structure-function relationships of EP-specific proteins.

3. Investigation of Regulatory Genes in Pathophysiology of Craniosynostosis

   Rochester, Minn.

   The purpose of this study is to collect tissue (during the initial procedure only) that is surgically removed (and routinely discarded at Mayo Clinic) from CS patients. Portions of the tissue will be embedded in plastic for histological and histomorphometric analysis. A small portion of the tissue will be used for outgrowth cultures to isolate cells. Nucleic acid and protein will be extracted from the remaining portions of the tissue and/or isolated cell lines to examine candidate genes and their role in the disease process.

4. The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

   Rochester, Minn.

   The purpose of this study is to identify and distinguish two different types of Progressive Apraxia of Speech through clinical imaging and testing.

5. Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure

   Rochester, Minn.

   The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external ventriculostomy drain (EVD) or ventriculostomy catheter.

6. A Study of Neurophysiological and Inflammatory Biomarkers of Seizures and Brain Injury in Children

   Rochester, Minn.

   The purpose of this study is to connect brain inflammation measured by biomarkers, with data from advanced EEG technology, and clinical outcomes to provide new predictive information about seizure activity in children with critical brain injuries and epilepsy.

7. Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

   Rochester, Minn., Jacksonville, Fla.

   Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary progressive aphasia (PPA), corticobasal degeneration syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). The goal of this study is to build a FTLD clinical research consortium to support the development of FTLD therapies for new clinical trials. The consortium, referred to as Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL), will be headquartered at UCSF and will partner with six patient advocacy groups to manage the consortium. Participants will be evaluated at 14 clinical sites throughout North America and a genetics core will genotype all individuals for FTLD associated genes.

8. A Study to Evaluate Prevention of Paclitaxel-Associated Neuropathy with Fingolimod

   Rochester, Minn.

   The purpose of this study is to determine if the use of Gilenya® can reduce neuropathy caused by paclitaxel.

    

9. Collection and Storage of DNA and Plasma in Patients with Dysautonomia and Healthy Controls

   Rochester, Minn.

   This study is being done to better understand the causes of autonomic disorders, and to collect and store DNA and plasma for future studies of autonomic disorders.

10. A Study of Atrial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

    Jacksonville, Fla.

    The primary purpose of this study is to test the theory that Eliquis (apixaban) is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy.