Nefrología e hipertensión

A continuación se enumeran ensayos clínicos actuales.

Filtrar esta lista de estudios según la ubicación, el estado del estudio y más.

1. Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   This is a double-blind, randomized-withdrawal, placebo-controlled study consisting of 2 treatment periods, and a post-treatment Follow-up Period during which retreatment is permitted if needed.

2. A Study to Evaluate the Use of Lung and intra-abdominal vessels Ultrasond for Intradialytic Complications in Hospitalized Patients on Intermittent Hemodialysis

   Rochester, Minn.

   The purpose of this study is to investigate hospitalized, non-ICU patients undergoing intermittent hemodialysis (HD) to determine:

   • If the combined use of lung and intra-abdominal vessels ultrasound in volume assessment would be better for estimation of dry weight
   • If the changes of the lung ultrasound B line numbers as well as portal venous flow pulsatility and IVC diameters could predict intra-dialytic manifestations and/or complications, such as hypotension, hypertension, tachycardia, and change in oxygen requirements
   • If findings seen with a hand-held scanner are similar to a portable ultrasound scanner

3. PRevention of Acute Kidney Injury Initiated with Electronic Surveillance Enhancement

   Rochester, Minn.

   Introduction: Acute kidney injury (AKI) increases mortality, hospital cost, and rate of progression toward end stage kidney disease 1-4. Early diagnosis and management of AKI is known to improve the above mentioned outcomes.

   Hypothesis: the investigators will design and validate an electronic surveillance tool to screen all the ICU admissions for the earlier, more efficient diagnosis of AKI and as a result improve the outcome of AKI in ICU patients.

   Methods: the investigators plan to use the patient database, and AKIN (AKI network) definition to design an electronic alert system to allow clinicians discover patients who develop AKI. Then a randomized clinical trial will be conducted to compare earlier intervention (based on Kidney Disease: Improving Global Outcomes [KDIGO] guidelines) initiated by AKI sniffer alert to the conventional management provided by primary physician in ICU.

4. A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)

   Rochester, Minn.

   The purpose of this study is to evaluate the effect of cemdisiran on proteinuria in adults with immunoglobulin A nephropathy (IgAN), who excrete >1 gram (gm) of protein per day despite standard of care, which includes treatment with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). These patients are at high risk for progression of kidney disease, which can result in end-stage renal failure.

5. A Prevalence and Incidence Study Burden of Atrial and Ventricular Arrhythmias in Patients with Sleep Apnea and Hypertrophic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to determine prevalence of sleep apnea in patients with hypertrophic cardiomyopathy and the risk of atrial and ventricular arrhythmias.

6. COVID-19 and Acute Renal Failure

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The primary purpose of this study is to examine 1-year survival and rate of secondary infections in COVID-19 patients with and without acute kidney injury (AKI).

    

    

    

7. Prospective Research Rare Kidney Stones

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.

8. A Study to Compare the Outcomes and Complications of Mini-Percutaneous Nephrolithotomy (mini-PCNL) Versus Standard PCNL

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to compare the operative outcomes and complications of mini-percutaneous nephrolithotomy (mini-PCNL) versus standard PCNL for renal stones.

9. A Study to Assess Palliative Care Impact on Patients with End-stage Renal Disease

   Jacksonville, Fla.

   The purpose of this study is to evaluate the impact of palliative care consultations on quality of life and advance care planning in end-stage renal disease patients on hemodialysis, evaluate hemodialysis patients’ and caregivers’ satisfaction with palliative care consultations, and to compare quality of life and advance directive completion in dialysis patients who have and have not received palliative care consultations.

10. Training of Physicians in Critical Care Ultrasonography (CCUS)

    Rochester, Minn.

    The purpose of this study is to assess the improvement in physician’s knowledge and skill sets in ultrasonography after the implementation of simulation-based educational program.  

A continuación se enumeran ensayos clínicos actuales.

Filtrar esta lista de estudios según la ubicación, el estado del estudio y más.

1. Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   This is a double-blind, randomized-withdrawal, placebo-controlled study consisting of 2 treatment periods, and a post-treatment Follow-up Period during which retreatment is permitted if needed.

2. A Study to Evaluate the Use of Lung and intra-abdominal vessels Ultrasond for Intradialytic Complications in Hospitalized Patients on Intermittent Hemodialysis

   Rochester, Minn.

   The purpose of this study is to investigate hospitalized, non-ICU patients undergoing intermittent hemodialysis (HD) to determine:

   • If the combined use of lung and intra-abdominal vessels ultrasound in volume assessment would be better for estimation of dry weight
   • If the changes of the lung ultrasound B line numbers as well as portal venous flow pulsatility and IVC diameters could predict intra-dialytic manifestations and/or complications, such as hypotension, hypertension, tachycardia, and change in oxygen requirements
   • If findings seen with a hand-held scanner are similar to a portable ultrasound scanner

3. A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)

   Rochester, Minn.

   The purpose of this study is to evaluate the effect of cemdisiran on proteinuria in adults with immunoglobulin A nephropathy (IgAN), who excrete >1 gram (gm) of protein per day despite standard of care, which includes treatment with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). These patients are at high risk for progression of kidney disease, which can result in end-stage renal failure.

4. PRevention of Acute Kidney Injury Initiated with Electronic Surveillance Enhancement

   Rochester, Minn.

   Introduction: Acute kidney injury (AKI) increases mortality, hospital cost, and rate of progression toward end stage kidney disease 1-4. Early diagnosis and management of AKI is known to improve the above mentioned outcomes.

   Hypothesis: the investigators will design and validate an electronic surveillance tool to screen all the ICU admissions for the earlier, more efficient diagnosis of AKI and as a result improve the outcome of AKI in ICU patients.

   Methods: the investigators plan to use the patient database, and AKIN (AKI network) definition to design an electronic alert system to allow clinicians discover patients who develop AKI. Then a randomized clinical trial will be conducted to compare earlier intervention (based on Kidney Disease: Improving Global Outcomes [KDIGO] guidelines) initiated by AKI sniffer alert to the conventional management provided by primary physician in ICU.

5. A Prevalence and Incidence Study Burden of Atrial and Ventricular Arrhythmias in Patients with Sleep Apnea and Hypertrophic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to determine prevalence of sleep apnea in patients with hypertrophic cardiomyopathy and the risk of atrial and ventricular arrhythmias.

6. COVID-19 and Acute Renal Failure

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The primary purpose of this study is to examine 1-year survival and rate of secondary infections in COVID-19 patients with and without acute kidney injury (AKI).

    

    

    

7. Prospective Research Rare Kidney Stones

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.

8. A Study to Compare the Outcomes and Complications of Mini-Percutaneous Nephrolithotomy (mini-PCNL) Versus Standard PCNL

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to compare the operative outcomes and complications of mini-percutaneous nephrolithotomy (mini-PCNL) versus standard PCNL for renal stones.

9. A Study to Assess Palliative Care Impact on Patients with End-stage Renal Disease

   Jacksonville, Fla.

   The purpose of this study is to evaluate the impact of palliative care consultations on quality of life and advance care planning in end-stage renal disease patients on hemodialysis, evaluate hemodialysis patients’ and caregivers’ satisfaction with palliative care consultations, and to compare quality of life and advance directive completion in dialysis patients who have and have not received palliative care consultations.

10. Training of Physicians in Critical Care Ultrasonography (CCUS)

    Rochester, Minn.

    The purpose of this study is to assess the improvement in physician’s knowledge and skill sets in ultrasonography after the implementation of simulation-based educational program.