Chad M. Ruoff, M.D.

  1. Sleep Medicine Specialist


  1. Chen C, Rosen CL, Ruoff C, et al. Population and Noncompartmental Pharmokinetics of Sodium Oxybate Support Weight-Based Dosing in Children and Adolescents with Narcolepsy with Cataplexy. G Clin Transl Sci. 2020 Sep; 13(5):932-40.
  2. Plazzi G, Ruoff C, et al. Treatment of pediatric narcolepsy with sodium oxybate: a double-blind, placebo­ controlled, randomised-withdrawal multicentre study and open-label evaluation. Lancet Child Adolesc Health. 2018 Jul; 2(7):483-94.
  3. Scapuccin M, Schneider L, Rashid N, Zaghi S, Rosa T, David Liu S, Lazarini P, Capasso R, Ruoff C. Feasibility and Utility of Independent Nasal Flow Monitoring During Routine Polysomnograms: The Nasal Cycle. J Clin Sleep Medicine. 2018 Mar.
  4. Cheung J, Ruoff C, Hagerman K, Day J, Mignot E, Sampson J. Increased Theta Power in Myotonic Dystrophy J Clin Sleep Medicine. 2018 Feb; 14(2):229-35.
  5. Ruoff C, Pizza F, Trotti LM, Sonka K, Vandi S, Cheung J, Pinto S, Einen M, Simakajornboon N, Han F, Peppard P, Nevsimalova S, Plazzi G, Rye D, Mignot E. The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study. J Clin Sleep Med. 2018 Jan 15; 14(1):65-74.
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  6. Ruoff C, Bogan RK, Emsellem H, Feldman N, Lankford A, Bream G, Khayrallah M, Lu Y, Carter LP, Black J. Evaluation of the effect of JZP-110 in patients with narcolepsy assessed using the Maintenance of Wakefulness Test censored to 20 minutes. Sleep Med. 2017 Jul; 35:12-16 Epub 2017 Apr 22
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  7. Ruoff CM, Reaven NL, Funk SE, McGaughey KJ, Ohayon MM, Guilleminault C, Black J. High Rates of Psychiatric Comorbidity in Narcolepsy: Findings From the Burden of Narcolepsy Disease (BOND) Study of 9,312 Patients in the United States. J Clin Psychiatry. 2017 Feb; 78 (2):171-176
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  8. Ruoff C, Rye D. The New ICSD-3 and DSM-5 Guidelines for Diagnosing Narcolepsy: Clinical Relevance and Practicality. Current Medical Research and Opinion. 2016 Jul; 32(10):1611-22.
  9. Ruoff C, Swick T, Doekel R, Emsellem H, Feldman N, Rosenberg R, Bream G, Khayrallah M, Lu Y, Black J. Effect of Oral JZP-110 (ADX-N05) on Wakefulness and Sleepiness in Adults with Narcolepsy: A Phase 2b study. Sleep. 2016.
  10. Black J, Reaven N, Funk S, McGaughery K, Ohayon M, Guilleminault C, Ruoff C. Medical Comorbidity in Narcolepsy: Findings from the Burden of Narcolepsy Disease (BOND) Study. Sleep Medicine. 2016.
  11. Camacho M, Ruoff CM, Kawai M, Modi R, Arbee J, Hekmat A, Robertson M, Zaghi S, Certal V, Capasso R, Kushida CA. Five-Minute Awake Snoring Test for Determining CPAP Pressures (Five-Minute CPAP Test): A Pilot Study. Sleep Disorders. 2016.
  12. Liebentha J, Valerio J, Ruoff C, Mahowald M. A Case of REM Sleep Behavior Disorder in Parkinson's Disease Treated with Sodium Oxybate. JAMA Neurology. 2016 Jan; 73(1):126-7.
  13. Camacho M, Robertson M, Abdullatif J, Certal V, Kram YA, Ruoff CM, Brietzke SE, Capasso R. Smartphone Apps for Snoring. Journal of Laryngology and Otology. 2015 Sep; 3:1-6.
  14. Dandekar F, Camacho M, Valerio J, Ruoff C. Periorbital Edema Secondary to Positive Airway Pressure Therapy. Case Reports in Ophthalmological Medicine. 2015; 3.
  15. Camacho M, Certal V, Abdullatif J, Zaghi S, Ruoff CM, Capasso R, Kushida C. Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Sleep. 2014 Oct.
  16. Camacho M, Ruoff C, et al. The Effect of Nasal Surgery on Continuous Positive Airway Pressure Device Use and Therapeutic Treatment Pressures: A Systematic Review and Meta-Analysis. Sleep. 2014 Oct.
  17. Goldbart A, Peppard P, Finn L, Ruoff C, Barnet J, Young T, Mignot E. Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep. 2014 Jun; 37(6):1043-51.
  18. Black J, Reaven N, Funk S, McGaughery K, Ohayon M, Guilleminault C, Ruoff C, Mignot E. The Burden of Narcolepsy Disease (BOND) Study: Healthcare Utilization and Cost Findings. Sleep Med. 2014 May; 15(5):522-9.
  19. Ruoff C, Black J. Psychiatric Dimensions of Narcolepsy. Psychiatric Times. 2014; 31(1):17-21.
  20. Ruoff C, Guilleminault C. Hypocretin receptor antagonists for insomnia: rationale and clinical data. Clinical Investigation. 2012; 2(6):623-37.
  21. Ruoff C, Cao M, Guilleminault C. Hypocretin antagonists in insomnia treatment and beyond. Curr Pharm Des. 2011; 17 (15):1476-82
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