Cefoperazone (Intramuscular Route, Intravenous Route) Precautions

Description and Brand Names

Drug information provided by: Merative, Micromedex®

Descriptions

Cefoperazone injection is used to treat bacterial infections in the different parts of the body.

Cefoperazone injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the supervision of your doctor.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of cefoperazone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefoperazone injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving cefoperazone injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cholera Vaccine, Live
Heparin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use

A nurse or other trained health professional will give you this medicine. It is given as a shot into a muscle or through a needle placed into a vein.

You should receive every dose that is prescribed to clear up your infection, even if you feel better after the first few doses. Your infection may not clear up if you stop receiving the medicine too soon.

Precautions

It is very important that your doctor check your progress while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause a serious allergic reaction, called anaphylaxis. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis) can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine.

Cefoperazone injection may cause diarrhea, and in some cases it can be severe and may occur 2 months or more after you stop receiving this medicine. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

This medicine may cause bleeding problems. Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal.

Before you have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

Do not drink alcohol during treatment and after you receive this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

Black, tarry, stools
bluish color of the skin
chills
cough
dark urine
difficulty in breathing or swallowing
fast heartbeat
fever
general tiredness and weakness
light-colored stools
lower back or side pain
nausea
pain or swelling at the injection site
painful or difficult urination
pale skin
skin itching, rash, or redness
sore throat
stomach cramps
swelling of the face, throat, or tongue
swelling of the foot or leg
tenderness
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
upper right stomach pain
vomiting
watery or bloody diarrhea
yellow eyes and skin

Incidence not known

Bleeding gums
bleeding under the skin
blistering, peeling, loosening of the skin
blood in the urine or stools
clay-colored stools
cold, clammy skin
confusion
coughing up blood
dizziness
fast, weak pulse
headache
increased menstrual flow or vaginal bleeding
joint or muscle pain
lightheadedness
loss of appetite
nosebleeds
paralysis
pinpoint red spots on the skin
prolonged bleeding from cuts
red, irritated eyes
red or black, tarry stools
red or dark brown urine
red skin lesions, often with a purple center
stomach pain
sweating
unpleasant breath odor
vomiting of blood

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: May 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/cefoperazone-intramuscular-route-intravenous-route/precautions/drg-20406573

Cefoperazone (Intramuscular Route, Intravenous Route)