To find out if you have shellfish allergy, your health care provider will ask about your symptoms and do a physical exam to find or rule out other medical problems.

A history of allergic reactions shortly after exposure to shellfish can be a sign of shellfish allergy. But the symptoms could also be caused by something else, such as food poisoning.

Allergy testing is the only sure way to tell what's causing your symptoms, so your provider may recommend one or both of these tests:

  • Skin prick test. Small amounts of the proteins found in shellfish are pricked into skin on your arm or upper back. You're then watched for an allergic reaction. If you're allergic, you'll develop a raised bump (hive) at the test site on your skin. This typically takes about 15 to 20 minutes. Allergy specialists usually are best equipped to perform allergy skin tests.
  • Blood test. A blood sample is sent to a lab to measure your immune system's response to a specific allergen. This test measures your immune system's response to shellfish proteins by measuring the amount of allergy-causing antibodies in your bloodstream, known as immunoglobulin E (IgE) antibodies.

Medically supervised food challenges can be performed if the diagnosis still isn't clear after allergy testing.

More Information


The only sure way to prevent an allergic reaction to shellfish is to avoid shellfish. But despite your best efforts, you may come into contact with shellfish.

If you have a severe allergic reaction to shellfish (anaphylaxis), you'll likely need an emergency injection of epinephrine (adrenaline). If you're at risk of anaphylaxis to shellfish, your health care provider can give you a prescription in advance and explain how and when to give the injection. Regularly check the expiration date on the packaging to make sure it's current.

Carry injectable epinephrine (Auvi-Q, EpiPen, others) with you at all times. Epinephrine is typically given at the first sign of an allergic reaction. A second dose may be needed if symptoms recur. After you use epinephrine, seek emergency medical care, even if you start to feel better.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Preparing for your appointment

You're likely to start by seeing your family health care provider. Or you may be referred directly to an allergy specialist.

What you can do

Prepare for your appointment by making a list of:

  • Symptoms, including any that may seem unrelated to an allergy
  • Family history of allergies and asthma, including specific types of allergies if you know them
  • Medications, vitamins, herbs or other supplements you're taking, and the dosages
  • Questions to ask your health care provider

Questions related to shellfish allergy include:

  • Are my symptoms most likely due to an allergy?
  • Will I need any allergy tests?
  • Should I see an allergist?
  • Do I need to carry epinephrine?
  • Are there brochures or other educational materials I can have? What websites do you recommend?

Don't hesitate to ask other questions, as well.

What to expect from your doctor

Your health care provider may ask you questions, such as:

  • What symptoms are you having? How severe are they?
  • When did you notice your symptoms?
  • Have you reacted to shellfish in the past?
  • What kind of shellfish did you eat?
  • How soon after eating shellfish did your symptoms occur?
  • What other foods did you eat during your meal? Don't forget sauces, beverages and side dishes.
  • Did others who dined with you have similar symptoms?
  • Is there a history of allergy in your family?
  • Do you have other allergies, such as hay fever?
  • Do you have asthma or eczema (atopic dermatitis)?

What you can do in the meantime

Avoid eating or touching any type of shellfish while waiting for your appointment.

Aug. 05, 2022
  1. Shellfish. American College of Allergy, Asthma and Immunology. https://acaai.org/allergies/allergic-conditions/food/shellfish/. Accessed April 27, 2022.
  2. Shaker MS, et al. Anaphylaxis — A 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis. Journal of Allergy and Clinical Immunology. 2020; doi:10.1016/j.jaci.2020.01.017.
  3. Anaphylaxis. American Academy of Allergy, Asthma & Immunology. https://acaai.org/allergies/symptoms/anaphylaxis/. Accessed April 27, 2022.
  4. Sicherer SH. Seafood allergies: Fish and shellfish. https://www.uptodate.com/contents/search. Accessed April 27, 2022.
  5. Cameron P, et al., eds. Computed tomography scanning in emergency medicine. In: Textbook of Adult Emergency Medicine. 5th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed April 27, 2022.
  6. Ruethers T, et al. Seafood allergy: A comprehensive review of fish and shellfish allergens. Molecular Immunology. 2018; doi:10.1016/j.molimm.2018.04.008.
  7. Wong L, et al. An update on shellfish allergy. Current Opinion in Allergy and Clinical Immunology. 2019; doi:10.1097/ACI.0000000000000532.
  8. Li JTC (expert opinion). Mayo Clinic. May 4, 2022.


Associated Procedures

Products & Services