Primary sclerosing cholangitis (PSC)

By Mayo Clinic Staff
Oct. 15, 2025

Research

Mayo Clinic researchers were among the first to describe PSC. Other research done at Mayo has helped to refine diagnostic tests, improve treatment and assess the results of liver transplants for people with PSC.

Mayo Clinic researchers also developed mathematical models to help physicians predict long-term survival for people with PSC. Researchers at Mayo Clinic also advanced the use of the fluorescence in situ hybridization, also called FISH, test in the diagnosis of bile duct cancer in people with PSC.

Researchers at Mayo Clinic also are studying the DNA of people with PSC in hopes of identifying genes that increase the risk of the disease and predict its course. Basic research related to PSC and other liver diseases is conducted in the following Mayo Clinic laboratories:

Publications

See a list of publications about primary sclerosing cholangitis (PSC) by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Primary sclerosing cholangitis (PSC). American College of Gastroenterology. https://gi.org/topics/primary-sclerosing-cholangitis-psc/. Accessed April 29, 2025.
  2. Manns MP, et al. Primary sclerosing cholangitis. Nature Reviews Disease Primers. 2025; doi:10.1038/s41572-025-00600-x.
  3. Ferri FF. Primary sclerosing cholangitis. In: Ferri's Clinical Advisor 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed April 29, 2025.
  4. Burt AD, et al., eds. Bile duct diseases. In: MacSween's Pathology of the Liver. 8th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed April 29, 2025.
  5. Barberio B, et al. Prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease: A systematic review and meta-analysis. Gastroenterology. 2021; doi:10.1053/j.gastro.2021.08.032.
  6. Kowdley KV. Primary sclerosing cholangitis in adults: Clinical manifestations and diagnosis. https://www.uptodate.com/contents/search. Accessed April 29, 2025.
  7. Bhushan S, et al. Primary biliary cholangitis and primary sclerosing cholangitis therapy landscape. American Journal of Gastroenterology. 2025; doi:10.14309/ajg.0000000000003174.
  8. Portal hypertension. Merck Manual Professional Version. https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/approach-to-the-patient-with-liver-disease/portal-hypertension. Accessed May 5, 2025.
  9. Kowdley KV. Primary sclerosing cholangitis in adults: Management. https://www.uptodate.com/contents/search. Accessed April 29, 2025.
  10. Poupon R. Pruritus associated with cholestasis. https://www.uptodate.com/contents/search. Accessed May 6, 2025.
  11. Wheless WH, et al. Treatment of primary sclerosing cholangitis including transplantation. Clinical Liver Disease. 2024; doi:10.1016/j.cld.2023.07.008.
  12. Liver disease and fatigue. Canadian Society of Intestinal Research. https://badgut.org/information-centre/a-z-digestive-topics/liver-disease-fatigue/. Accessed May 6, 2025.
  13. 25 ways to love your liver. American Liver Foundatoin. https://liverfoundation.org/resource-center/blog/25-ways-to-love-your-liver-health/. Accessed May 6, 2025.
  14. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Dec. 3, 2024.
  15. Medical review (expert opinion). Mayo Clinic. May 10, 2025.