Primary progressive aphasia

By Mayo Clinic Staff
Feb. 08, 2025

Research

Mayo Clinic experts actively research primary progressive aphasia and related conditions. Researchers study risk factors, causes, diagnostic techniques and potential treatments. Read more about research in Alzheimer's disease and speech and language disorders.

The Mayo Clinic Alzheimer's Disease Research Center at Mayo Clinic's campuses in Florida and Minnesota is among the more than 30 Alzheimer's disease centers in the United States. These centers are designated and funded by the National Institute on Aging. Mayo researchers in the center study frontotemporal dementia, Alzheimer's disease and related conditions. You may have the opportunity to participate in clinical trials in the center. Mayo Clinic's campus in Arizona is part of the Arizona Alzheimer's Consortium, a statewide research collaboration.

Publications

See a list of publications about primary progressive aphasia by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Primary progressive aphasia. National Aphasia Association. http://www.aphasia.org/aphasia-resources/primary-progressive-aphasia/. Accessed Jan. 6, 2025.
  2. Lee SE, et al. Frontotemporal dementia: Clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Jan. 6, 2025.
  3. Jankovic J, et al., eds. Alzheimer disease and other dementias. In: Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Feb. 20, 2023.
  4. Budson AE, et al. Primary progressive aphasia and apraxia of speech. In: Memory Loss, Alzheimer's Disease, and Dementia. 3rd ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Feb. 20, 2023.
  5. Baratono S, et al. What are the key diagnostic cognitive impairment and dementia subtypes and how to integrate all of the diagnostic data to establish a diagnosis? Clinics in Geriatric Medicine. 2023; doi:10.1016/j.cger.2022.08.002.
  6. Coemans S, et al. Executive functions in primary progressive aphasia: A meta-analysis. Cortex. 2022; doi:10.1016/j.cortex.2022.
  7. Nicolo Aiello E, et al. Primary progressive aphasia and motor neuron disease: A review. Frontiers in Aging Neuroscience. 2022; doi:10.3389/fnagi.2022.1003792.
  8. Aphasia. American Speech-Language-Hearing Association. https://www.asha.org/public/speech/disorders/aphasia/. Accessed Jan. 6, 2025.
  9. A diagnosis of primary progressive aphasia? What to expect. National Aphasia Association. https://www.aphasia.org/stories/ppa-what-to-expect/. Accessed Jan. 6, 2025.
  10. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Dec. 27, 2024.
  11. Srinivasan J, et al., eds. Dementia: Mild cognitive impairment, Alzheimer disease, Lewy Body Dementia, Frontotemporal Lobar Dementia, Vascular Dementia. In: Netter's Neurology. 3rd ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Feb. 21, 2023.
  12. Tippett DC, et al. Clinical and neuroimaging characteristics of primary progressive aphasia. Handbook of Clinical Neurology. 2022; doi:10.1016/B978-0-12-823384-9.00016-5.
  13. Tartaglia MC, et al. Recent advances in frontotemporal dementia. Canadian Journal of Neurological Sciences. 2022; doi:10.1017/cjn.2022.69.
  14. Providing care for a person with a frontotemporal disorder. National Institute on Aging. https://www.nia.nih.gov/health/providing-care-person-frontotemporal-disorder. Accessed Jan. 6, 2025.
  15. Support for people with FTD. Association for Frontotemporal Degeneration. https://www.theaftd.org/living-with-ftd/support-for-people-with-ftd/. Accessed Jan. 6, 2025.
  16. Alzheimer's disease research centers. National Institute on Aging. https://www.nia.nih.gov/health/alzheimers-disease-research-centers. Accessed Jan. 6, 2025.
  17. Arizona Alzheimer's Consortium. http://azalz.org/about-us/. Accessed Jan. 6, 2025.
  18. Botha H, et al. Primary progressive aphasia and apraxia of speech. Continuum. 2019; doi:10.1212/CON.0000000000000699.
  19. Medical review (expert opinion). Mayo Clinic. Jan. 17, 2025.